link
Bookmarks
 (0)
Cardiac
Diagnosis
Heart Failure and Cardiomyopathies
Takotsubo Cardiomyopathy
Takotsubo Cardiomyopathy
Sanjeev A. Francis, MD, FACC
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
4
0
0

KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Stress-induced cardiomyopathy
          • Apical ballooning syndrome

        • Definitions

          • Reversible dysfunction of left ventricle (LV) in absence of significant coronary artery stenosis
            • Classically described following periods of severe emotional or physical stress
              • In recent prospective multicenter study, stressful trigger was identified in ~ 70% of patients
            • Often accompanied by acute chest pain, ischemic ST segment abnormalities, and elevation of cardiac biomarkers

        IMAGING

        • General Features

          • Imaging Recommendations

            • Nuclear Medicine Findings

              • CT Findings

                • MR Findings

                  • Echocardiographic Findings

                    • Angiographic Findings

                      • Image-Guided Biopsy

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Citro R et al: Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction. Eur J Heart Fail. ePub, 2019
                                          2. Templin C et al: Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome. Eur Heart J. ePub, 2019
                                          3. Scally C et al: Persistent long-term structural, functional, and metabolic changes after stress-induced (Takotsubo) cardiomyopathy. Circulation. 137(10):1039-48, 2018
                                          4. Abbas A et al: Cardiac magnetic resonance assessment of takotsubo cardiomyopathy. Clin Radiol. 71(1):e110-9, 2016
                                          5. Plácido R et al: The role of cardiovascular magnetic resonance in takotsubo syndrome. J Cardiovasc Magn Reson. 18(1):68, 2016
                                          6. Rajiah P et al: Update on the role of cardiac magnetic resonance in acquired nonischemic cardiomyopathies. J Thorac Imaging. 31(6):348-66, 2016
                                          7. Garg P et al: Important role of myocardial tissue characterization by cardiac MRI in diagnosing Takotsubo syndrome. Nat Rev Cardiol. 12(11):669, 2015
                                          8. Kohan AA et al: Usefulness of MRI in takotsubo cardiomyopathy: a review of the literature. Cardiovasc Diagn Ther. 4(2):138-46, 2014
                                          9. Nakamori S et al: Prevalence and signal characteristics of late gadolinium enhancement on contrast-enhanced magnetic resonance imaging in patients with takotsubo cardiomyopathy. Circ J. 76(4):914-21, 2012
                                          10. Eitel I et al: Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA. 306(3):277-86, 2011
                                          11. King A: Cardiomyopathies: CMR sheds new light on the clinical profile of stress cardiomyopathy. Nat Rev Cardiol. 8(9):480, 2011
                                          12. Naruse Y et al: The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images. J Cardiovasc Magn Reson. 13:67, 2011
                                          13. Bellera MN et al: Magnetic resonance reveals long-term sequelae of apical ballooning syndrome. Int J Cardiol. 139(1):25-31, 2010
                                          14. Hurst RT et al: Takotsubo cardiomyopathy: a unique cardiomyopathy with variable ventricular morphology. JACC Cardiovasc Imaging. 3(6):641-9, 2010
                                          15. Sharkey SW et al: Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy. J Am Coll Cardiol. 55(4):333-41, 2010
                                          16. Celik T et al: Stress-induced (Takotsubo) cardiomyopathy: a transient disorder. Int J Cardiol. 131(2):265-6, 2009
                                          17. Kurisu S et al: Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy. Coron Artery Dis. 20(3):214-8, 2009
                                          18. Rolf A et al: Immunohistological basis of the late gadolinium enhancement phenomenon in tako-tsubo cardiomyopathy. Eur Heart J. 30(13):1635-42, 2009
                                          19. Dorfman TA et al: An unusual manifestation of Takotsubo cardiomyopathy. Clin Cardiol. 31(5):194-200, 2008
                                          20. Arora S: Autonomic imbalance in patients with takotsubo cardiomyopathy: cause or association? QJM. 100(9):593-4; author reply 594-6, 2007
                                          21. Cocco G et al: Stress-induced cardiomyopathy: a review. Eur J Intern Med. 18(5):369-79, 2007
                                          22. Haghi D et al: Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy. Circ J. 71(10):1664; author reply 1665, 2007
                                          23. Kawai S: Typical and atypical forms of takotsubo (ampulla) cardiomyopathy. Circ J. 71(10):1665, 2007
                                          24. Kimura K et al: Images in cardiovascular medicine. Rapid formation of left ventricular giant thrombus with Takotsubo cardiomyopathy. Circulation. 115(23):e620-1, 2007
                                          25. Matsuzaki M: Stress 'Takotsubo' cardiomyopathy: questions still remain. Nat Clin Pract Cardiovasc Med. 4(11):577, 2007
                                          26. Nanda S et al: Takotsubo cardiomyopathy--a new variant and widening disease spectrum. Int J Cardiol. 120(2):e34-6, 2007
                                          27. Pilgrim TM et al: Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome: A systematic review. Int J Cardiol. 2007
                                          28. Gianni M et al: Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J. 27(13):1523-9, 2006
                                          29. Iqbal MB et al: Stress, emotion and the heart: tako-tsubo cardiomyopathy. Postgrad Med J. 82(974):e29, 2006
                                          30. Bybee KA et al: Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 141(11):858-65, 2004
                                          31. Ito T et al: Development of pulmonary neuroendocrine cells of fetal hamster in explant culture. Lab Invest. 77(5):449-57, 1997
                                          Related Anatomy
                                          Loading...
                                          Related Differential Diagnoses
                                          Loading...
                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Stress-induced cardiomyopathy
                                                  • Apical ballooning syndrome

                                                • Definitions

                                                  • Reversible dysfunction of left ventricle (LV) in absence of significant coronary artery stenosis
                                                    • Classically described following periods of severe emotional or physical stress
                                                      • In recent prospective multicenter study, stressful trigger was identified in ~ 70% of patients
                                                    • Often accompanied by acute chest pain, ischemic ST segment abnormalities, and elevation of cardiac biomarkers

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Nuclear Medicine Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Echocardiographic Findings

                                                            • Angiographic Findings

                                                              • Image-Guided Biopsy

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Citro R et al: Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction. Eur J Heart Fail. ePub, 2019
                                                                                  2. Templin C et al: Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome. Eur Heart J. ePub, 2019
                                                                                  3. Scally C et al: Persistent long-term structural, functional, and metabolic changes after stress-induced (Takotsubo) cardiomyopathy. Circulation. 137(10):1039-48, 2018
                                                                                  4. Abbas A et al: Cardiac magnetic resonance assessment of takotsubo cardiomyopathy. Clin Radiol. 71(1):e110-9, 2016
                                                                                  5. Plácido R et al: The role of cardiovascular magnetic resonance in takotsubo syndrome. J Cardiovasc Magn Reson. 18(1):68, 2016
                                                                                  6. Rajiah P et al: Update on the role of cardiac magnetic resonance in acquired nonischemic cardiomyopathies. J Thorac Imaging. 31(6):348-66, 2016
                                                                                  7. Garg P et al: Important role of myocardial tissue characterization by cardiac MRI in diagnosing Takotsubo syndrome. Nat Rev Cardiol. 12(11):669, 2015
                                                                                  8. Kohan AA et al: Usefulness of MRI in takotsubo cardiomyopathy: a review of the literature. Cardiovasc Diagn Ther. 4(2):138-46, 2014
                                                                                  9. Nakamori S et al: Prevalence and signal characteristics of late gadolinium enhancement on contrast-enhanced magnetic resonance imaging in patients with takotsubo cardiomyopathy. Circ J. 76(4):914-21, 2012
                                                                                  10. Eitel I et al: Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA. 306(3):277-86, 2011
                                                                                  11. King A: Cardiomyopathies: CMR sheds new light on the clinical profile of stress cardiomyopathy. Nat Rev Cardiol. 8(9):480, 2011
                                                                                  12. Naruse Y et al: The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images. J Cardiovasc Magn Reson. 13:67, 2011
                                                                                  13. Bellera MN et al: Magnetic resonance reveals long-term sequelae of apical ballooning syndrome. Int J Cardiol. 139(1):25-31, 2010
                                                                                  14. Hurst RT et al: Takotsubo cardiomyopathy: a unique cardiomyopathy with variable ventricular morphology. JACC Cardiovasc Imaging. 3(6):641-9, 2010
                                                                                  15. Sharkey SW et al: Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy. J Am Coll Cardiol. 55(4):333-41, 2010
                                                                                  16. Celik T et al: Stress-induced (Takotsubo) cardiomyopathy: a transient disorder. Int J Cardiol. 131(2):265-6, 2009
                                                                                  17. Kurisu S et al: Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy. Coron Artery Dis. 20(3):214-8, 2009
                                                                                  18. Rolf A et al: Immunohistological basis of the late gadolinium enhancement phenomenon in tako-tsubo cardiomyopathy. Eur Heart J. 30(13):1635-42, 2009
                                                                                  19. Dorfman TA et al: An unusual manifestation of Takotsubo cardiomyopathy. Clin Cardiol. 31(5):194-200, 2008
                                                                                  20. Arora S: Autonomic imbalance in patients with takotsubo cardiomyopathy: cause or association? QJM. 100(9):593-4; author reply 594-6, 2007
                                                                                  21. Cocco G et al: Stress-induced cardiomyopathy: a review. Eur J Intern Med. 18(5):369-79, 2007
                                                                                  22. Haghi D et al: Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy. Circ J. 71(10):1664; author reply 1665, 2007
                                                                                  23. Kawai S: Typical and atypical forms of takotsubo (ampulla) cardiomyopathy. Circ J. 71(10):1665, 2007
                                                                                  24. Kimura K et al: Images in cardiovascular medicine. Rapid formation of left ventricular giant thrombus with Takotsubo cardiomyopathy. Circulation. 115(23):e620-1, 2007
                                                                                  25. Matsuzaki M: Stress 'Takotsubo' cardiomyopathy: questions still remain. Nat Clin Pract Cardiovasc Med. 4(11):577, 2007
                                                                                  26. Nanda S et al: Takotsubo cardiomyopathy--a new variant and widening disease spectrum. Int J Cardiol. 120(2):e34-6, 2007
                                                                                  27. Pilgrim TM et al: Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome: A systematic review. Int J Cardiol. 2007
                                                                                  28. Gianni M et al: Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J. 27(13):1523-9, 2006
                                                                                  29. Iqbal MB et al: Stress, emotion and the heart: tako-tsubo cardiomyopathy. Postgrad Med J. 82(974):e29, 2006
                                                                                  30. Bybee KA et al: Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 141(11):858-65, 2004
                                                                                  31. Ito T et al: Development of pulmonary neuroendocrine cells of fetal hamster in explant culture. Lab Invest. 77(5):449-57, 1997
                                                                                  Contact UsStoreTerms and ConditionsRegistered User AgreementPrivacy PolicyHelp