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Talcosis
Carlos S. Restrepo, MD; Jud W. Gurney, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Inhalational talcosis = talc pneumoconiosis
              • Intravenous talcosis = talc granulomatosis or excipient lung disease
            • Definitions

              • 4 forms: 3 inhalational, 1 intravenous
                • Inhalational talcosis (pure talc exposure)
                • Inhalational talcosilicosis (exposure to talc and silica)
                • Inhalational talcoasbestosis (exposure to talc and asbestos)
                • Intravenous talcosis
                  • Pure intravenous talcosis
                  • Intravenous talcosis and methylphenidate

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Nguyen VT et al: Pulmonary effects of i.v. injection of crushed oral tablets: "excipient lung disease". AJR Am J Roentgenol. 203(5):W506-15, 2014
                                        2. Marchiori E et al: Pulmonary talcosis: imaging findings. Lung. 188(2):165-71, 2010
                                        3. van Huisstede A et al: Talcosis due to abundant use of cosmetic talcum powder. Eur Respir Rev. 19(116):165-8, 2010
                                        4. Akira M et al: Inhalational talc pneumoconiosis: radiographic and CT findings in 14 patients. AJR Am J Roentgenol. 188(2):326-33, 2007
                                        5. Chong S et al: Pneumoconiosis: comparison of imaging and pathologic findings. Radiographics. 26(1):59-77, 2006
                                        6. Dekel Y et al: Talc inhalation is a life-threatening condition. Pathol Oncol Res. 10(4):231-3, 2004
                                        7. Ward S et al: Talcosis associated with IV abuse of oral medications: CT findings. AJR Am J Roentgenol. 174(3):789-93, 2000
                                        8. Stern EJ et al: Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. AJR Am J Roentgenol. 162(3):555-60, 1994
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Inhalational talcosis = talc pneumoconiosis
                                                    • Intravenous talcosis = talc granulomatosis or excipient lung disease
                                                  • Definitions

                                                    • 4 forms: 3 inhalational, 1 intravenous
                                                      • Inhalational talcosis (pure talc exposure)
                                                      • Inhalational talcosilicosis (exposure to talc and silica)
                                                      • Inhalational talcoasbestosis (exposure to talc and asbestos)
                                                      • Intravenous talcosis
                                                        • Pure intravenous talcosis
                                                        • Intravenous talcosis and methylphenidate

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Nguyen VT et al: Pulmonary effects of i.v. injection of crushed oral tablets: "excipient lung disease". AJR Am J Roentgenol. 203(5):W506-15, 2014
                                                                              2. Marchiori E et al: Pulmonary talcosis: imaging findings. Lung. 188(2):165-71, 2010
                                                                              3. van Huisstede A et al: Talcosis due to abundant use of cosmetic talcum powder. Eur Respir Rev. 19(116):165-8, 2010
                                                                              4. Akira M et al: Inhalational talc pneumoconiosis: radiographic and CT findings in 14 patients. AJR Am J Roentgenol. 188(2):326-33, 2007
                                                                              5. Chong S et al: Pneumoconiosis: comparison of imaging and pathologic findings. Radiographics. 26(1):59-77, 2006
                                                                              6. Dekel Y et al: Talc inhalation is a life-threatening condition. Pathol Oncol Res. 10(4):231-3, 2004
                                                                              7. Ward S et al: Talcosis associated with IV abuse of oral medications: CT findings. AJR Am J Roentgenol. 174(3):789-93, 2000
                                                                              8. Stern EJ et al: Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. AJR Am J Roentgenol. 162(3):555-60, 1994