Proliferative response of endometrium to selective estrogen receptor (SERM) therapy
IMAGING
General Features
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Abdel Razek AAK et al: Assessment of tamoxifen-related endometrial changes in premenopausal female patients with diffusion-weighted magnetic resonance imaging. J Comput Assist Tomogr. 44(4):485-9, 2020
Neven P et al: Uterine ultrasound and endometrial biopsy in tamoxifen users. Breast Cancer Res Treat. 180(3):833-4, 2020
Chen JY et al: Endometrial cancer incidence in breast cancer patients correlating with age and duration of tamoxifen use: a population based study. J Cancer. 5(2):151-5, 2014
Kalampokas T et al: Effect of tamoxifen on postmenopausal endometrium. Eur J Gynaecol Oncol. 34(4):325-8, 2013
Kazerooni T et al: The value of transvaginal ultrasonography in the endometrial evaluation of breast cancer patients using tamoxifen. Med Princ Pract. 19(3):222-7, 2010
Polin SA et al: The effect of tamoxifen on the genital tract. Cancer Imaging. 8:135-45, 2008
Garuti G et al: Pretreatment and prospective assessment of endometrium in menopausal women taking tamoxifen for breast cancer. Eur J Obstet Gynecol Reprod Biol. 132(1):101-6, 2007
Fishman M et al: Changes in the sonographic appearance of the uterus after discontinuation of tamoxifen therapy. J Ultrasound Med. 25(4):469-73, 2006
Duffy S et al: The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: baseline endometrial sub-protocol data on the effectiveness of transvaginal ultrasonography and diagnostic hysteroscopy. Hum Reprod. 20(1):294-301, 2005
Develioglu OH et al: The endometrium in asymptomatic breast cancer patients on tamoxifen: value of transvaginal ultrasonography with saline infusion and Doppler flow. Gynecol Oncol. 93(2):328-35, 2004
Markovitch O et al: The value of sonohysterography in the prediction of endometrial pathologies in asymptomatic postmenopausal breast cancer tamoxifen-treated patients. Gynecol Oncol. 94(3):754-9, 2004
Markovitch O et al: The value of transvaginal ultrasonography in the prediction of endometrial pathologies in asymptomatic postmenopausal breast cancer tamoxifen-treated patients. Gynecol Oncol. 95(3):456-62, 2004
Fong K et al: Transvaginal US and hysterosonography in postmenopausal women with breast cancer receiving tamoxifen: correlation with hysteroscopy and pathologic study. Radiographics. 23(1):137-50; discussion 151-5, 2003
Fung MF et al: Prospective longitudinal study of ultrasound screening for endometrial abnormalities in women with breast cancer receiving tamoxifen. Gynecol Oncol. 91(1):154-9, 2003
Ascher SM et al: Tamoxifen-induced uterine abnormalities: the role of imaging. Radiology. 214(1):29-38, 2000
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KEY FACTS
Terminology
Imaging
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TERMINOLOGY
Definitions
Proliferative response of endometrium to selective estrogen receptor (SERM) therapy
IMAGING
General Features
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Abdel Razek AAK et al: Assessment of tamoxifen-related endometrial changes in premenopausal female patients with diffusion-weighted magnetic resonance imaging. J Comput Assist Tomogr. 44(4):485-9, 2020
Neven P et al: Uterine ultrasound and endometrial biopsy in tamoxifen users. Breast Cancer Res Treat. 180(3):833-4, 2020
Chen JY et al: Endometrial cancer incidence in breast cancer patients correlating with age and duration of tamoxifen use: a population based study. J Cancer. 5(2):151-5, 2014
Kalampokas T et al: Effect of tamoxifen on postmenopausal endometrium. Eur J Gynaecol Oncol. 34(4):325-8, 2013
Kazerooni T et al: The value of transvaginal ultrasonography in the endometrial evaluation of breast cancer patients using tamoxifen. Med Princ Pract. 19(3):222-7, 2010
Polin SA et al: The effect of tamoxifen on the genital tract. Cancer Imaging. 8:135-45, 2008
Garuti G et al: Pretreatment and prospective assessment of endometrium in menopausal women taking tamoxifen for breast cancer. Eur J Obstet Gynecol Reprod Biol. 132(1):101-6, 2007
Fishman M et al: Changes in the sonographic appearance of the uterus after discontinuation of tamoxifen therapy. J Ultrasound Med. 25(4):469-73, 2006
Duffy S et al: The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: baseline endometrial sub-protocol data on the effectiveness of transvaginal ultrasonography and diagnostic hysteroscopy. Hum Reprod. 20(1):294-301, 2005
Develioglu OH et al: The endometrium in asymptomatic breast cancer patients on tamoxifen: value of transvaginal ultrasonography with saline infusion and Doppler flow. Gynecol Oncol. 93(2):328-35, 2004
Markovitch O et al: The value of sonohysterography in the prediction of endometrial pathologies in asymptomatic postmenopausal breast cancer tamoxifen-treated patients. Gynecol Oncol. 94(3):754-9, 2004
Markovitch O et al: The value of transvaginal ultrasonography in the prediction of endometrial pathologies in asymptomatic postmenopausal breast cancer tamoxifen-treated patients. Gynecol Oncol. 95(3):456-62, 2004
Fong K et al: Transvaginal US and hysterosonography in postmenopausal women with breast cancer receiving tamoxifen: correlation with hysteroscopy and pathologic study. Radiographics. 23(1):137-50; discussion 151-5, 2003
Fung MF et al: Prospective longitudinal study of ultrasound screening for endometrial abnormalities in women with breast cancer receiving tamoxifen. Gynecol Oncol. 91(1):154-9, 2003
Ascher SM et al: Tamoxifen-induced uterine abnormalities: the role of imaging. Radiology. 214(1):29-38, 2000
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