Proliferation of dendritic cell histiocytes, which form granulomas within any organ system, including T-bone
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Ong AA et al: Langerhans cell histiocytosis of the skull. Ear Nose Throat J. 100(4):219-21, 2021
Mayer S et al: Langerhans cell histiocytosis of the temporal bone. Ochsner J. 20(3):315-8, 2020
Flaman AN et al: Ear and temporal bone pathology: neural, sclerosing and myofibroblastic lesions. Head Neck Pathol. 12(3):392-406, 2018
Haefliger S et al: PET-positive bone lesion due to Langerhans cell histiocytosis after BEACOPP therapy for Hodgkin lymphoma: how anamnesis, histopathological accuracy, and molecular analysis could resolve a clinical dilemma. Ann Hematol. 97(2):355-7, 2018
Zheng H et al: Pediatric Langerhans cell histiocytosis of the temporal bone: clinical and imaging studies of 27 cases. World J Surg Oncol. 16(1):72, 2018
Majumder A et al: Pediatric Langerhans cell histiocytosis of the lateral skull base. Int J Pediatr Otorhinolaryngol. 99:135-40, 2017
Chevallier KM et al: Differentiating pediatric rhabdomyosarcoma and Langerhans cell histiocytosis of the temporal bone by imaging appearance. AJNR Am J Neuroradiol. 37(6):1185-9, 2016
Shew M et al: Langerhan's cell histiocytosis in an immunosuppressed patient isolated to the temporal bone. Otol Neurotol. 37(6):e194-6, 2016
Mener DJ et al: Temporal bone involvement in Hand-Schuller-Christian disease. Otol Neurotol. 36(3):e95-6, 2015
Modest MC et al: Langerhans cell histiocytosis of the temporal bone: a review of 29 cases at a single center. Laryngoscope. 126(8):1899-904, 2015
Abdel-Aziz M et al: Eosinophilic granuloma of the temporal bone in children. J Craniofac Surg. 25(3):1076-8, 2014
Nabavizadeh SA et al: CT and MRI of pediatric skull lesions with fluid-fluid levels. AJNR Am J Neuroradiol. 35(3):604-8, 2014
Radhakrishnan R et al: Petrous apex lesions in the pediatric population. Pediatr Radiol. 44(3):325-39; quiz 323-4, 2014
Alexander RL et al: Langerhans cell histiocytosis: temporal bone invasion in an adult. Ear Nose Throat J. 92(10-11):496, 498, 2013
Coleman MA et al: Bilateral temporal bone langerhans cell histiocytosis: radiologic pearls. Open Neuroimag J. 7:53-7, 2013
Inci MF et al: Multidetector CT findings of calvarial eosinophilic granuloma. BMJ Case Rep, 2013
Neilan RE et al: Langerhans cell histiocytosis of the temporal bone. Otol Neurotol. 33(4):e31-2, 2012
Laurencikas E et al: Incidence and pattern of radiological central nervous system Langerhans cell histiocytosis in children: a population based study. Pediatr Blood Cancer. 56(2):250-7, 2011
Grois N et al: Central nervous system disease in Langerhans cell histiocytosis. J Pediatr. 156(6):873-81, 881, 2010
Nicollas R et al: Head and neck manifestation and prognosis of Langerhans' cell histiocytosis in children. Int J Pediatr Otorhinolaryngol. 74(6):669-73, 2010
Roger G et al: Cholesteatoma secondary to temporal bone involvement by Langerhans cell histiocytosis: a complication amenable to curative surgery. Otol Neurotol. 30(2):190-3, 2009
Saliba I et al: Prognostic indicators for sensorineural hearing loss in temporal bone histiocytosis. Int J Pediatr Otorhinolaryngol. 73(12):1616-20, 2009
Zlodre JK et al: Langerhans' cell histiocytosis of the temporal bone: successful treatment of sensorineural hearing loss with low-dose radiotherapy. J Laryngol Otol. 123(6):676-9, 2009
D'Ambrosio N et al: Craniofacial and intracranial manifestations of Langerhans cell histiocytosis: report of findings in 100 patients. AJR Am J Roentgenol. 191(2):589-97, 2008
Saliba I et al: Langerhans' cell histiocytosis of the temporal bone in children. Int J Pediatr Otorhinolaryngol. 72(6):775-86, 2008
del Río L et al: Petrous bone Langerhans cell histiocytosis treated with radiosurgery. Stereotact Funct Neurosurg. 85(2-3):129-31, 2007
Baumann C et al: Destruction of the vestibular organ by Langerhans' cell histiocytosis. Eur Radiol. 16(5):1177-8, 2006
de Brito Macedo Ferreira LM et al: Histiocytosis X of the temporal bone. Braz J Otorhinolaryngol. 72(4):575, 2006
Mosnier I et al: Langerhans' cell histiocytosis of the labyrinth in adults. Otol Neurotol. 25(1):27-32, 2004
Kleinjung T et al: Langerhans' cell histiocytosis with bilateral temporal bone involvement. Am J Otolaryngol. 24(4):265-70, 2003
Mistry H et al: Remodeling of the temporal bone after involvement with Langerhans' cell histiocytosis. Acta Radiol. 44(3):355, 2003
Boston M et al: Langerhans' cell histiocytosis of the temporal bone and skull base. Am J Otolaryngol. 23(4):246-8, 2002
Yetiser S et al: Eosinophilic granuloma of the bilateral temporal bone. Int J Pediatr Otorhinolaryngol. 62(2):169-73, 2002
Bayazit Y et al: Eosinophilic granuloma of the temporal bone. Auris Nasus Larynx. 28(1):99-102, 2001
Marioni G et al: Langerhans' cell histiocytosis: temporal bone involvement. J Laryngol Otol. 115(10):839-41, 2001
Fernández-Latorre F et al: Langerhans' cell histiocytosis of the temporal bone in pediatric patients: imaging and follow-up. AJR Am J Roentgenol. 174(1):217-21, 2000
Koch BL: Langerhans histiocytosis of temporal bone: role of magnetic resonance imaging. Top Magn Reson Imaging. 11(1):66-74, 2000
Bonafé A et al: Histiocytosis X of the petrous bone in the adult: MRI. Neuroradiology. 36(4):330-3, 1994
Goldsmith AJ et al: Unifocal Langerhans' cell histiocytosis (eosinophilic granuloma) of the petrous apex. Arch Otolaryngol Head Neck Surg. 119(1):113-6, 1993
Cunningham MJ et al: Histiocytosis X of the temporal bone: CT findings. J Comput Assist Tomogr. 12(1):70-4, 1988
Fradis M et al: Eosinophilic granuloma of the temporal bone. J Laryngol Otol. 99(5):475-9, 1985
Kimmelman CP et al: Histiocytosis X of the temporal bone. Otolaryngol Head Neck Surg. 92(5):588-90, 1984
McCaffrey TV et al: Histiocytosis X of the ear and temporal bone: review of 22 cases. Laryngoscope. 89(11):1735-42, 1979
Proliferation of dendritic cell histiocytes, which form granulomas within any organ system, including T-bone
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Ong AA et al: Langerhans cell histiocytosis of the skull. Ear Nose Throat J. 100(4):219-21, 2021
Mayer S et al: Langerhans cell histiocytosis of the temporal bone. Ochsner J. 20(3):315-8, 2020
Flaman AN et al: Ear and temporal bone pathology: neural, sclerosing and myofibroblastic lesions. Head Neck Pathol. 12(3):392-406, 2018
Haefliger S et al: PET-positive bone lesion due to Langerhans cell histiocytosis after BEACOPP therapy for Hodgkin lymphoma: how anamnesis, histopathological accuracy, and molecular analysis could resolve a clinical dilemma. Ann Hematol. 97(2):355-7, 2018
Zheng H et al: Pediatric Langerhans cell histiocytosis of the temporal bone: clinical and imaging studies of 27 cases. World J Surg Oncol. 16(1):72, 2018
Majumder A et al: Pediatric Langerhans cell histiocytosis of the lateral skull base. Int J Pediatr Otorhinolaryngol. 99:135-40, 2017
Chevallier KM et al: Differentiating pediatric rhabdomyosarcoma and Langerhans cell histiocytosis of the temporal bone by imaging appearance. AJNR Am J Neuroradiol. 37(6):1185-9, 2016
Shew M et al: Langerhan's cell histiocytosis in an immunosuppressed patient isolated to the temporal bone. Otol Neurotol. 37(6):e194-6, 2016
Mener DJ et al: Temporal bone involvement in Hand-Schuller-Christian disease. Otol Neurotol. 36(3):e95-6, 2015
Modest MC et al: Langerhans cell histiocytosis of the temporal bone: a review of 29 cases at a single center. Laryngoscope. 126(8):1899-904, 2015
Abdel-Aziz M et al: Eosinophilic granuloma of the temporal bone in children. J Craniofac Surg. 25(3):1076-8, 2014
Nabavizadeh SA et al: CT and MRI of pediatric skull lesions with fluid-fluid levels. AJNR Am J Neuroradiol. 35(3):604-8, 2014
Radhakrishnan R et al: Petrous apex lesions in the pediatric population. Pediatr Radiol. 44(3):325-39; quiz 323-4, 2014
Alexander RL et al: Langerhans cell histiocytosis: temporal bone invasion in an adult. Ear Nose Throat J. 92(10-11):496, 498, 2013
Coleman MA et al: Bilateral temporal bone langerhans cell histiocytosis: radiologic pearls. Open Neuroimag J. 7:53-7, 2013
Inci MF et al: Multidetector CT findings of calvarial eosinophilic granuloma. BMJ Case Rep, 2013
Neilan RE et al: Langerhans cell histiocytosis of the temporal bone. Otol Neurotol. 33(4):e31-2, 2012
Laurencikas E et al: Incidence and pattern of radiological central nervous system Langerhans cell histiocytosis in children: a population based study. Pediatr Blood Cancer. 56(2):250-7, 2011
Grois N et al: Central nervous system disease in Langerhans cell histiocytosis. J Pediatr. 156(6):873-81, 881, 2010
Nicollas R et al: Head and neck manifestation and prognosis of Langerhans' cell histiocytosis in children. Int J Pediatr Otorhinolaryngol. 74(6):669-73, 2010
Roger G et al: Cholesteatoma secondary to temporal bone involvement by Langerhans cell histiocytosis: a complication amenable to curative surgery. Otol Neurotol. 30(2):190-3, 2009
Saliba I et al: Prognostic indicators for sensorineural hearing loss in temporal bone histiocytosis. Int J Pediatr Otorhinolaryngol. 73(12):1616-20, 2009
Zlodre JK et al: Langerhans' cell histiocytosis of the temporal bone: successful treatment of sensorineural hearing loss with low-dose radiotherapy. J Laryngol Otol. 123(6):676-9, 2009
D'Ambrosio N et al: Craniofacial and intracranial manifestations of Langerhans cell histiocytosis: report of findings in 100 patients. AJR Am J Roentgenol. 191(2):589-97, 2008
Saliba I et al: Langerhans' cell histiocytosis of the temporal bone in children. Int J Pediatr Otorhinolaryngol. 72(6):775-86, 2008
del Río L et al: Petrous bone Langerhans cell histiocytosis treated with radiosurgery. Stereotact Funct Neurosurg. 85(2-3):129-31, 2007
Baumann C et al: Destruction of the vestibular organ by Langerhans' cell histiocytosis. Eur Radiol. 16(5):1177-8, 2006
de Brito Macedo Ferreira LM et al: Histiocytosis X of the temporal bone. Braz J Otorhinolaryngol. 72(4):575, 2006
Mosnier I et al: Langerhans' cell histiocytosis of the labyrinth in adults. Otol Neurotol. 25(1):27-32, 2004
Kleinjung T et al: Langerhans' cell histiocytosis with bilateral temporal bone involvement. Am J Otolaryngol. 24(4):265-70, 2003
Mistry H et al: Remodeling of the temporal bone after involvement with Langerhans' cell histiocytosis. Acta Radiol. 44(3):355, 2003
Boston M et al: Langerhans' cell histiocytosis of the temporal bone and skull base. Am J Otolaryngol. 23(4):246-8, 2002
Yetiser S et al: Eosinophilic granuloma of the bilateral temporal bone. Int J Pediatr Otorhinolaryngol. 62(2):169-73, 2002
Bayazit Y et al: Eosinophilic granuloma of the temporal bone. Auris Nasus Larynx. 28(1):99-102, 2001
Marioni G et al: Langerhans' cell histiocytosis: temporal bone involvement. J Laryngol Otol. 115(10):839-41, 2001
Fernández-Latorre F et al: Langerhans' cell histiocytosis of the temporal bone in pediatric patients: imaging and follow-up. AJR Am J Roentgenol. 174(1):217-21, 2000
Koch BL: Langerhans histiocytosis of temporal bone: role of magnetic resonance imaging. Top Magn Reson Imaging. 11(1):66-74, 2000
Bonafé A et al: Histiocytosis X of the petrous bone in the adult: MRI. Neuroradiology. 36(4):330-3, 1994
Goldsmith AJ et al: Unifocal Langerhans' cell histiocytosis (eosinophilic granuloma) of the petrous apex. Arch Otolaryngol Head Neck Surg. 119(1):113-6, 1993
Cunningham MJ et al: Histiocytosis X of the temporal bone: CT findings. J Comput Assist Tomogr. 12(1):70-4, 1988
Fradis M et al: Eosinophilic granuloma of the temporal bone. J Laryngol Otol. 99(5):475-9, 1985
Kimmelman CP et al: Histiocytosis X of the temporal bone. Otolaryngol Head Neck Surg. 92(5):588-90, 1984
McCaffrey TV et al: Histiocytosis X of the ear and temporal bone: review of 22 cases. Laryngoscope. 89(11):1735-42, 1979
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