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KEY FACTS
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Synonyms
- Formerly pigmented villonodular synovitis (PVNS)
- Benign synovioma; focal nodular synovitis
Definitions
- Low-grade fibrohistiocytic proliferation with hemosiderin deposits in synovial joints
- 2 subtypes
- Diffuse tenosynovial giant cell tumor (TSGCT)
- Localized TSGCT
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Crim J et al: Limited usefulness of classic MR findings in the diagnosis of tenosynovial giant cell tumor. Skeletal Radiol. 50(8):1585-91, 2021
- Finkelstein D et al: Differential diagnosis of T2 hypointense masses in musculoskeletal MRI. Skeletal Radiol. 50(10):1981-94, 2021
- Ota T et al: Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study. Sci Rep. 11(1):17384, 2021
- Spierenburg G et al: Management of tenosynovial giant cell tumour of the foot and ankle. Bone Joint J. 103-B(4):788-94, 2021
- Dundar A et al: Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation. Skeletal Radiol. 49(3):483-9, 2020
- Tap W: ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT). Future Oncol. 16(25):1875-8, 2020
- Gouin F et al: Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res. 103(1S):S91-7, 2017
- Mollon B et al: Combined arthroscopic and open synovectomy for diffuse pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc. 24(1):260-6, 2014
- Verspoor FG et al: Long-term follow-up results of primary and recurrent pigmented villonodular synovitis. Rheumatology (Oxford). 53(11):2063-70, 2014
- Aurégan JC et al: Primary arthroscopic synovectomy for pigmented villo-nodular synovitis of the knee: recurrence rate and functional outcomes after a mean follow-up of seven years. Orthop Traumatol Surg Res. 99(8):937-43, 2013
- Botez P et al: Adult multifocal pigmented villonodular synovitis--clinical review. Int Orthop. 37(4):729-33, 2013
- Colman MW et al: Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates? Clin Orthop Relat Res. 471(3):883-90, 2013
- Berger B et al: External beam radiotherapy as postoperative treatment of diffuse pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 67(4):1130-4, 2007
- Ward WG Sr et al: Diffuse pigmented villonodular synovitis: preliminary results with intralesional resection and p32 synoviorthesis. Clin Orthop Relat Res. 454:186-91, 2007
- Wu CC et al: Two incision synovectomy and radiation treatment for diffuse pigmented villonodular synovitis of the knee with extra-articular component. Knee. 14(2):99-106, 2007
- Chiari C et al: What affects the recurrence and clinical outcome of pigmented villonodular synovitis? Clin Orthop Relat Res. 450:172-8, 2006
- Finis K et al: Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. Arthritis Rheum. 54(3):1009-19, 2006
- Mendenhall WM et al: Pigmented villonodular synovitis. Am J Clin Oncol. 29(6):548-50, 2006
- Tyler WK et al: Pigmented villonodular synovitis. J Am Acad Orthop Surg. 14(6):376-85, 2006
- Stubbs AJ et al: Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. Arthroscopy. 21(7):893, 2005
- Manaster BJ et al: Musculoskeletal Imaging: The Requisites. 2nd ed. Mosby, Elsevier, 2002
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Synonyms
- Formerly pigmented villonodular synovitis (PVNS)
- Benign synovioma; focal nodular synovitis
Definitions
- Low-grade fibrohistiocytic proliferation with hemosiderin deposits in synovial joints
- 2 subtypes
- Diffuse tenosynovial giant cell tumor (TSGCT)
- Localized TSGCT
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Crim J et al: Limited usefulness of classic MR findings in the diagnosis of tenosynovial giant cell tumor. Skeletal Radiol. 50(8):1585-91, 2021
- Finkelstein D et al: Differential diagnosis of T2 hypointense masses in musculoskeletal MRI. Skeletal Radiol. 50(10):1981-94, 2021
- Ota T et al: Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study. Sci Rep. 11(1):17384, 2021
- Spierenburg G et al: Management of tenosynovial giant cell tumour of the foot and ankle. Bone Joint J. 103-B(4):788-94, 2021
- Dundar A et al: Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation. Skeletal Radiol. 49(3):483-9, 2020
- Tap W: ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT). Future Oncol. 16(25):1875-8, 2020
- Gouin F et al: Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res. 103(1S):S91-7, 2017
- Mollon B et al: Combined arthroscopic and open synovectomy for diffuse pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc. 24(1):260-6, 2014
- Verspoor FG et al: Long-term follow-up results of primary and recurrent pigmented villonodular synovitis. Rheumatology (Oxford). 53(11):2063-70, 2014
- Aurégan JC et al: Primary arthroscopic synovectomy for pigmented villo-nodular synovitis of the knee: recurrence rate and functional outcomes after a mean follow-up of seven years. Orthop Traumatol Surg Res. 99(8):937-43, 2013
- Botez P et al: Adult multifocal pigmented villonodular synovitis--clinical review. Int Orthop. 37(4):729-33, 2013
- Colman MW et al: Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates? Clin Orthop Relat Res. 471(3):883-90, 2013
- Berger B et al: External beam radiotherapy as postoperative treatment of diffuse pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 67(4):1130-4, 2007
- Ward WG Sr et al: Diffuse pigmented villonodular synovitis: preliminary results with intralesional resection and p32 synoviorthesis. Clin Orthop Relat Res. 454:186-91, 2007
- Wu CC et al: Two incision synovectomy and radiation treatment for diffuse pigmented villonodular synovitis of the knee with extra-articular component. Knee. 14(2):99-106, 2007
- Chiari C et al: What affects the recurrence and clinical outcome of pigmented villonodular synovitis? Clin Orthop Relat Res. 450:172-8, 2006
- Finis K et al: Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. Arthritis Rheum. 54(3):1009-19, 2006
- Mendenhall WM et al: Pigmented villonodular synovitis. Am J Clin Oncol. 29(6):548-50, 2006
- Tyler WK et al: Pigmented villonodular synovitis. J Am Acad Orthop Surg. 14(6):376-85, 2006
- Stubbs AJ et al: Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. Arthroscopy. 21(7):893, 2005
- Manaster BJ et al: Musculoskeletal Imaging: The Requisites. 2nd ed. Mosby, Elsevier, 2002
