Low-grade fibrohistiocytic proliferation with hemosiderin deposits in synovial joints
2 subtypes
Diffuse tenosynovial giant cell tumor (TSGCT)
Localized TSGCT
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Crim J et al: Limited usefulness of classic MR findings in the diagnosis of tenosynovial giant cell tumor. Skeletal Radiol. 50(8):1585-91, 2021
Finkelstein D et al: Differential diagnosis of T2 hypointense masses in musculoskeletal MRI. Skeletal Radiol. 50(10):1981-94, 2021
Ota T et al: Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study. Sci Rep. 11(1):17384, 2021
Spierenburg G et al: Management of tenosynovial giant cell tumour of the foot and ankle. Bone Joint J. 103-B(4):788-94, 2021
Dundar A et al: Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation. Skeletal Radiol. 49(3):483-9, 2020
Tap W: ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT). Future Oncol. 16(25):1875-8, 2020
Gouin F et al: Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res. 103(1S):S91-7, 2017
Mollon B et al: Combined arthroscopic and open synovectomy for diffuse pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc. 24(1):260-6, 2014
Verspoor FG et al: Long-term follow-up results of primary and recurrent pigmented villonodular synovitis. Rheumatology (Oxford). 53(11):2063-70, 2014
Botez P et al: Adult multifocal pigmented villonodular synovitis--clinical review. Int Orthop. 37(4):729-33, 2013
Colman MW et al: Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates? Clin Orthop Relat Res. 471(3):883-90, 2013
Berger B et al: External beam radiotherapy as postoperative treatment of diffuse pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 67(4):1130-4, 2007
Ward WG Sr et al: Diffuse pigmented villonodular synovitis: preliminary results with intralesional resection and p32 synoviorthesis. Clin Orthop Relat Res. 454:186-91, 2007
Wu CC et al: Two incision synovectomy and radiation treatment for diffuse pigmented villonodular synovitis of the knee with extra-articular component. Knee. 14(2):99-106, 2007
Chiari C et al: What affects the recurrence and clinical outcome of pigmented villonodular synovitis? Clin Orthop Relat Res. 450:172-8, 2006
Finis K et al: Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. Arthritis Rheum. 54(3):1009-19, 2006
Mendenhall WM et al: Pigmented villonodular synovitis. Am J Clin Oncol. 29(6):548-50, 2006
Tyler WK et al: Pigmented villonodular synovitis. J Am Acad Orthop Surg. 14(6):376-85, 2006
Stubbs AJ et al: Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. Arthroscopy. 21(7):893, 2005
Manaster BJ et al: Musculoskeletal Imaging: The Requisites. 2nd ed. Mosby, Elsevier, 2002
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Synonyms
Formerly pigmented villonodular synovitis (PVNS)
Benign synovioma; focal nodular synovitis
Definitions
Low-grade fibrohistiocytic proliferation with hemosiderin deposits in synovial joints
2 subtypes
Diffuse tenosynovial giant cell tumor (TSGCT)
Localized TSGCT
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Crim J et al: Limited usefulness of classic MR findings in the diagnosis of tenosynovial giant cell tumor. Skeletal Radiol. 50(8):1585-91, 2021
Finkelstein D et al: Differential diagnosis of T2 hypointense masses in musculoskeletal MRI. Skeletal Radiol. 50(10):1981-94, 2021
Ota T et al: Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study. Sci Rep. 11(1):17384, 2021
Spierenburg G et al: Management of tenosynovial giant cell tumour of the foot and ankle. Bone Joint J. 103-B(4):788-94, 2021
Dundar A et al: Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation. Skeletal Radiol. 49(3):483-9, 2020
Tap W: ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT). Future Oncol. 16(25):1875-8, 2020
Gouin F et al: Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res. 103(1S):S91-7, 2017
Mollon B et al: Combined arthroscopic and open synovectomy for diffuse pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc. 24(1):260-6, 2014
Verspoor FG et al: Long-term follow-up results of primary and recurrent pigmented villonodular synovitis. Rheumatology (Oxford). 53(11):2063-70, 2014
Botez P et al: Adult multifocal pigmented villonodular synovitis--clinical review. Int Orthop. 37(4):729-33, 2013
Colman MW et al: Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates? Clin Orthop Relat Res. 471(3):883-90, 2013
Berger B et al: External beam radiotherapy as postoperative treatment of diffuse pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 67(4):1130-4, 2007
Ward WG Sr et al: Diffuse pigmented villonodular synovitis: preliminary results with intralesional resection and p32 synoviorthesis. Clin Orthop Relat Res. 454:186-91, 2007
Wu CC et al: Two incision synovectomy and radiation treatment for diffuse pigmented villonodular synovitis of the knee with extra-articular component. Knee. 14(2):99-106, 2007
Chiari C et al: What affects the recurrence and clinical outcome of pigmented villonodular synovitis? Clin Orthop Relat Res. 450:172-8, 2006
Finis K et al: Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. Arthritis Rheum. 54(3):1009-19, 2006
Mendenhall WM et al: Pigmented villonodular synovitis. Am J Clin Oncol. 29(6):548-50, 2006
Tyler WK et al: Pigmented villonodular synovitis. J Am Acad Orthop Surg. 14(6):376-85, 2006
Stubbs AJ et al: Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. Arthroscopy. 21(7):893, 2005
Manaster BJ et al: Musculoskeletal Imaging: The Requisites. 2nd ed. Mosby, Elsevier, 2002
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