Infiltrative testicular neoplasm with large, atypical lymphoid cells surrounding and compressing seminiferous tubules with preserved testicular vasculature
IMAGING
General Features
Ultrasonographic Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Rohena-Quinquilla IR et al: Imaging of extranodal genitourinary lymphoma. Radiol Clin North Am. 54(4):747-64, 2016
Kachramanoglou C et al: Multiparametric sonography of hematologic malignancies of the testis: grayscale, color Doppler, and contrast-enhanced ultrasound and strain elastographic appearances with histologic correlation. J Ultrasound Med. 36(2):409-20, 2017
Sukswai N et al: Diffuse large B-cell lymphoma variants: an update. Pathology. 52(1):53-67, 2020
Mittal PK et al: Spectrum of extratesticular and testicular pathologic conditions at scrotal MR imaging. Radiographics. 38(3):806-30, 2018
Twa DDW et al: The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies. Blood Rev. 32(3):249-55, 2018
Karaosmanoglu AD et al: Primary lymphomas of the intraabdominal solid organs and the gastrointestinal tract: spectrum of imaging findings with histopathological confirmation. Abdom Radiol (NY). 44(9):2988-3005, 2019
Xu H et al: Primary testicular lymphoma: A SEER analysis of 1,169 cases. Oncol Lett. 17(3):3113-24, 2019
Coursey Moreno C et al: Testicular tumors: what radiologists need to know--differential diagnosis, staging, and management. Radiographics. 35(2):400-15, 2015
Ratkal V et al: Testicular non-Hodgkin's lymphoma presenting in a young adult. BMJ Case Rep. 2015, 2015
Jain R et al: Unusual sites of relapse in pre-B acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 36(8):e506-8, 2014
Lokesh KN et al: Primary diffuse large B-cell lymphoma of testis: a single centre experience and review of literature. Urol Ann. 6(3):231-4, 2014
Bertolotto M et al: Grayscale and color Doppler features of testicular lymphoma. J Ultrasound Med. 34(6):1139-45, 2015
Liu KL et al: Imaging diagnosis of testicular lymphoma. Abdom Imaging. 31(5):610-2, 2006
Barnum R: A suggested framework for forensic consultation in cases of child abuse and neglect. J Am Acad Psychiatry Law. 25(4):581-93, 1997
Mazzu D et al: Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. AJR Am J Roentgenol. 164(3):645-7, 1995
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Non-Hodgkin testicular lymphoma
Definitions
Infiltrative testicular neoplasm with large, atypical lymphoid cells surrounding and compressing seminiferous tubules with preserved testicular vasculature
IMAGING
General Features
Ultrasonographic Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Rohena-Quinquilla IR et al: Imaging of extranodal genitourinary lymphoma. Radiol Clin North Am. 54(4):747-64, 2016
Kachramanoglou C et al: Multiparametric sonography of hematologic malignancies of the testis: grayscale, color Doppler, and contrast-enhanced ultrasound and strain elastographic appearances with histologic correlation. J Ultrasound Med. 36(2):409-20, 2017
Sukswai N et al: Diffuse large B-cell lymphoma variants: an update. Pathology. 52(1):53-67, 2020
Mittal PK et al: Spectrum of extratesticular and testicular pathologic conditions at scrotal MR imaging. Radiographics. 38(3):806-30, 2018
Twa DDW et al: The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies. Blood Rev. 32(3):249-55, 2018
Karaosmanoglu AD et al: Primary lymphomas of the intraabdominal solid organs and the gastrointestinal tract: spectrum of imaging findings with histopathological confirmation. Abdom Radiol (NY). 44(9):2988-3005, 2019
Xu H et al: Primary testicular lymphoma: A SEER analysis of 1,169 cases. Oncol Lett. 17(3):3113-24, 2019
Coursey Moreno C et al: Testicular tumors: what radiologists need to know--differential diagnosis, staging, and management. Radiographics. 35(2):400-15, 2015
Ratkal V et al: Testicular non-Hodgkin's lymphoma presenting in a young adult. BMJ Case Rep. 2015, 2015
Jain R et al: Unusual sites of relapse in pre-B acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 36(8):e506-8, 2014
Lokesh KN et al: Primary diffuse large B-cell lymphoma of testis: a single centre experience and review of literature. Urol Ann. 6(3):231-4, 2014
Bertolotto M et al: Grayscale and color Doppler features of testicular lymphoma. J Ultrasound Med. 34(6):1139-45, 2015
Liu KL et al: Imaging diagnosis of testicular lymphoma. Abdom Imaging. 31(5):610-2, 2006
Barnum R: A suggested framework for forensic consultation in cases of child abuse and neglect. J Am Acad Psychiatry Law. 25(4):581-93, 1997
Mazzu D et al: Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. AJR Am J Roentgenol. 164(3):645-7, 1995
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