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Testicular Lymphoma and Leukemia
Shweta Bhatt, MD; Kyle K. Jensen, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Non-Hodgkin testicular lymphoma
            • Definitions

              • Infiltrative testicular neoplasm with large, atypical lymphoid cells surrounding and compressing seminiferous tubules with preserved testicular vasculature

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • MR Findings

                  • Imaging Recommendations

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Rohena-Quinquilla IR et al: Imaging of extranodal genitourinary lymphoma. Radiol Clin North Am. 54(4):747-64, 2016
                                        2. Kachramanoglou C et al: Multiparametric sonography of hematologic malignancies of the testis: grayscale, color Doppler, and contrast-enhanced ultrasound and strain elastographic appearances with histologic correlation. J Ultrasound Med. 36(2):409-20, 2017
                                        3. Sukswai N et al: Diffuse large B-cell lymphoma variants: an update. Pathology. 52(1):53-67, 2020
                                        4. Mittal PK et al: Spectrum of extratesticular and testicular pathologic conditions at scrotal MR imaging. Radiographics. 38(3):806-30, 2018
                                        5. Twa DDW et al: The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies. Blood Rev. 32(3):249-55, 2018
                                        6. Karaosmanoglu AD et al: Primary lymphomas of the intraabdominal solid organs and the gastrointestinal tract: spectrum of imaging findings with histopathological confirmation. Abdom Radiol (NY). 44(9):2988-3005, 2019
                                        7. Xu H et al: Primary testicular lymphoma: A SEER analysis of 1,169 cases. Oncol Lett. 17(3):3113-24, 2019
                                        8. Coursey Moreno C et al: Testicular tumors: what radiologists need to know--differential diagnosis, staging, and management. Radiographics. 35(2):400-15, 2015
                                        9. Ratkal V et al: Testicular non-Hodgkin's lymphoma presenting in a young adult. BMJ Case Rep. 2015, 2015
                                        10. Jain R et al: Unusual sites of relapse in pre-B acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 36(8):e506-8, 2014
                                        11. Lokesh KN et al: Primary diffuse large B-cell lymphoma of testis: a single centre experience and review of literature. Urol Ann. 6(3):231-4, 2014
                                        12. Bertolotto M et al: Grayscale and color Doppler features of testicular lymphoma. J Ultrasound Med. 34(6):1139-45, 2015
                                        13. Liu KL et al: Imaging diagnosis of testicular lymphoma. Abdom Imaging. 31(5):610-2, 2006
                                        14. Barnum R: A suggested framework for forensic consultation in cases of child abuse and neglect. J Am Acad Psychiatry Law. 25(4):581-93, 1997
                                        15. Mazzu D et al: Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. AJR Am J Roentgenol. 164(3):645-7, 1995
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Non-Hodgkin testicular lymphoma
                                                  • Definitions

                                                    • Infiltrative testicular neoplasm with large, atypical lymphoid cells surrounding and compressing seminiferous tubules with preserved testicular vasculature

                                                  IMAGING

                                                  • General Features

                                                    • Ultrasonographic Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          • Nuclear Medicine Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Rohena-Quinquilla IR et al: Imaging of extranodal genitourinary lymphoma. Radiol Clin North Am. 54(4):747-64, 2016
                                                                              2. Kachramanoglou C et al: Multiparametric sonography of hematologic malignancies of the testis: grayscale, color Doppler, and contrast-enhanced ultrasound and strain elastographic appearances with histologic correlation. J Ultrasound Med. 36(2):409-20, 2017
                                                                              3. Sukswai N et al: Diffuse large B-cell lymphoma variants: an update. Pathology. 52(1):53-67, 2020
                                                                              4. Mittal PK et al: Spectrum of extratesticular and testicular pathologic conditions at scrotal MR imaging. Radiographics. 38(3):806-30, 2018
                                                                              5. Twa DDW et al: The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies. Blood Rev. 32(3):249-55, 2018
                                                                              6. Karaosmanoglu AD et al: Primary lymphomas of the intraabdominal solid organs and the gastrointestinal tract: spectrum of imaging findings with histopathological confirmation. Abdom Radiol (NY). 44(9):2988-3005, 2019
                                                                              7. Xu H et al: Primary testicular lymphoma: A SEER analysis of 1,169 cases. Oncol Lett. 17(3):3113-24, 2019
                                                                              8. Coursey Moreno C et al: Testicular tumors: what radiologists need to know--differential diagnosis, staging, and management. Radiographics. 35(2):400-15, 2015
                                                                              9. Ratkal V et al: Testicular non-Hodgkin's lymphoma presenting in a young adult. BMJ Case Rep. 2015, 2015
                                                                              10. Jain R et al: Unusual sites of relapse in pre-B acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 36(8):e506-8, 2014
                                                                              11. Lokesh KN et al: Primary diffuse large B-cell lymphoma of testis: a single centre experience and review of literature. Urol Ann. 6(3):231-4, 2014
                                                                              12. Bertolotto M et al: Grayscale and color Doppler features of testicular lymphoma. J Ultrasound Med. 34(6):1139-45, 2015
                                                                              13. Liu KL et al: Imaging diagnosis of testicular lymphoma. Abdom Imaging. 31(5):610-2, 2006
                                                                              14. Barnum R: A suggested framework for forensic consultation in cases of child abuse and neglect. J Am Acad Psychiatry Law. 25(4):581-93, 1997
                                                                              15. Mazzu D et al: Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. AJR Am J Roentgenol. 164(3):645-7, 1995