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Thick Skull
Miral D. Jhaveri, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Skull thickening (ST), calvarial thickening
            • Definitions

              • Diploic space expansion ± adjacent cortical thickening

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Borra VM et al: Localization of the gene for X-linked calvarial hyperostosis to chromosome Xq27.3-Xqter. Bone. 58:67-71, 2014
                                            2. Suoranta S et al: Thickened skull, scoliosis and other skeletal findings in Unverricht-Lundborg disease link cystatin B function to bone metabolism. Bone. 51(6):1016-24, 2012
                                            3. Akhaddar A et al: Nonsuppurative calvarial thickening: a new form of Garré disease? J Neurosurg. 110(4):808, 2009
                                            4. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                            5. Waclawik AJ: Hyperostosis frontalis interna. Arch Neurol. 63(2):291, 2006
                                            6. Sharma RR et al: Symptomatic cranial fibrous dysplasias: clinico-radiological analysis in a series of eight operative cases with follow-up results. J Clin Neurosci. 9(4): 381-90, 2002
                                            7. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5): 1191-216, 2002
                                            8. Ikedo D et al: Stimulatory effects of phenytoin on osteoblastic differentiation of fetal rat calvaria cells in culture. Bone. 25(6): 653-60, 1999
                                            9. Lazzeri S et al: Epidermal nevus syndrome: MR of intracranial involvement. AJNR Am J Neuroradiol. 14(5): 1255-7, 1993
                                            10. Atalar MH et al: Cerebral hemiatrophy (Dyke-Davidoff-Masson syndrome) in childhood: clinicoradiological analysis of 19 cases. 49(1):70-5, Pediatr
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • Skull thickening (ST), calvarial thickening
                                                      • Definitions

                                                        • Diploic space expansion ± adjacent cortical thickening

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Borra VM et al: Localization of the gene for X-linked calvarial hyperostosis to chromosome Xq27.3-Xqter. Bone. 58:67-71, 2014
                                                                                      2. Suoranta S et al: Thickened skull, scoliosis and other skeletal findings in Unverricht-Lundborg disease link cystatin B function to bone metabolism. Bone. 51(6):1016-24, 2012
                                                                                      3. Akhaddar A et al: Nonsuppurative calvarial thickening: a new form of Garré disease? J Neurosurg. 110(4):808, 2009
                                                                                      4. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                                                                      5. Waclawik AJ: Hyperostosis frontalis interna. Arch Neurol. 63(2):291, 2006
                                                                                      6. Sharma RR et al: Symptomatic cranial fibrous dysplasias: clinico-radiological analysis in a series of eight operative cases with follow-up results. J Clin Neurosci. 9(4): 381-90, 2002
                                                                                      7. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5): 1191-216, 2002
                                                                                      8. Ikedo D et al: Stimulatory effects of phenytoin on osteoblastic differentiation of fetal rat calvaria cells in culture. Bone. 25(6): 653-60, 1999
                                                                                      9. Lazzeri S et al: Epidermal nevus syndrome: MR of intracranial involvement. AJNR Am J Neuroradiol. 14(5): 1255-7, 1993
                                                                                      10. Atalar MH et al: Cerebral hemiatrophy (Dyke-Davidoff-Masson syndrome) in childhood: clinicoradiological analysis of 19 cases. 49(1):70-5, Pediatr