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Thrombotic Microangiopathies (HUS/TTP)
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Thrombotic microangiopathies (TMAs)
              • Disseminated intravascular coagulation (DIC)
              • Thrombocytopenic thrombotic purpura (TTP)
              • Hemolytic-uremic syndrome (HUS)
            • Definitions

              • Includes 3 major disorders
                • TTP (± HUS)
                • Disseminated intravascular coagulopathy (DIC)
                • Malignant hypertension (mHTN)

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Treatment

                                Selected References

                                1. Zheng XL et al: Pathogenesis of thrombotic microangiopathies. Annu Rev Pathol. 3:249-77, 2008
                                2. Garewal M et al: MRI changes in thrombotic microangiopathy secondary to malignant hypertension. J Neuroimaging. 17(2):178-80, 2007
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Thrombotic microangiopathies (TMAs)
                                            • Disseminated intravascular coagulation (DIC)
                                            • Thrombocytopenic thrombotic purpura (TTP)
                                            • Hemolytic-uremic syndrome (HUS)
                                          • Definitions

                                            • Includes 3 major disorders
                                              • TTP (± HUS)
                                              • Disseminated intravascular coagulopathy (DIC)
                                              • Malignant hypertension (mHTN)

                                          IMAGING

                                          • General Features

                                            • Imaging Recommendations

                                              • CT Findings

                                                • MR Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Microscopic Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Treatment

                                                              Selected References

                                                              1. Zheng XL et al: Pathogenesis of thrombotic microangiopathies. Annu Rev Pathol. 3:249-77, 2008
                                                              2. Garewal M et al: MRI changes in thrombotic microangiopathy secondary to malignant hypertension. J Neuroimaging. 17(2):178-80, 2007