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TMJ Calcium Pyrophosphate Dihydrate Deposition Disease
Kristine M. Mosier, DMD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Calcium pyrophosphate dihydrate deposition disease (CPPD)
            • Synonyms

              • Pseudogout
              • Tophaceous pseudogout, pseudotumor, destructive CPDD arthropathy, CPDD deposition disease
            • Definitions

              • Metabolic disease resulting in peri- or intraarticular chondrocalcinosis
                • Tophaceous (tumoral) CPPD form most prevalent in TMJ

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Treatment

                              Selected References

                              1. Morales H et al: Imaging approach to temporomandibular joint disorders. Clin Neuroradiol. 26(1):5-22, 2016
                              2. Abdelsayed RA et al: Tophaceous pseudogout of the temporomandibular joint: a series of 3 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 117(3):369-75, 2014
                              3. Petscavage-Thomas JM et al: Unlocking the jaw: advanced imaging of the temporomandibular joint. AJR Am J Roentgenol. 203(5):1047-1058, 2014
                              4. Meltzer, DE at al: Extradiskal pathology of temporomandibular joint: MR imaging and CT manifestations. Neurographics. 3:185-193, 2013
                              5. Magarelli N et al: Imaging of chondrocalcinosis: calcium pyrophosphate dihydrate (CPPD) crystal deposition disease -- imaging of common sites of involvement. Clin Exp Rheumatol. 30(1):118-25, 2012
                              6. Zweifel D et al: Tophaceuos calcium pyrophosphate dihydrate deposition disease of the temporomandibular joint: the preferential site? J Oral Maxillofac Surg. 70(1):60-7, 2012
                              7. Kamani T et al: Chondrocalcinosis of the temporomandibular joint: a rare but important diagnosis. Ear Nose Throat J. 88(9):E6-9, 2009
                              8. Naqvi AH et al: Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint - FNA findings and microanalysis. Cytojournal. 5:8, 2008
                              9. Reynolds JL et al: Tophaceous calcium pyrophosphate dihydrate deposition disease of the temporomandibular joint. J Rheumatol. 35(4):717-21, 2008
                              10. Rosenthal AK: Update in calcium deposition diseases. Curr Opin Rheumatol. 19(2):158-62, 2007
                              11. Marsot-Dupuch K et al: Massive calcium pyrophosphate dihydrate crystal deposition disease: a cause of pain of the temporomandibular joint. AJNR Am J Neuroradiol. 25(5):876-9, 2004
                              12. Aoyama S et al: Differential diagnosis of calcium pyrophosphate dihydrate deposition of the temporomandibular joint. Br J Oral Maxillofac Surg. 38(5):550-3, 2000
                              13. Srinivasan V et al: Calcium pyrophosphate deposition disease of the temporomandibular joint. J Neurol Surg Rep. 73(1):6-8, 2012
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Abbreviations

                                          • Calcium pyrophosphate dihydrate deposition disease (CPPD)
                                        • Synonyms

                                          • Pseudogout
                                          • Tophaceous pseudogout, pseudotumor, destructive CPDD arthropathy, CPDD deposition disease
                                        • Definitions

                                          • Metabolic disease resulting in peri- or intraarticular chondrocalcinosis
                                            • Tophaceous (tumoral) CPPD form most prevalent in TMJ

                                        IMAGING

                                        • General Features

                                          • CT Findings

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Treatment

                                                          Selected References

                                                          1. Morales H et al: Imaging approach to temporomandibular joint disorders. Clin Neuroradiol. 26(1):5-22, 2016
                                                          2. Abdelsayed RA et al: Tophaceous pseudogout of the temporomandibular joint: a series of 3 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 117(3):369-75, 2014
                                                          3. Petscavage-Thomas JM et al: Unlocking the jaw: advanced imaging of the temporomandibular joint. AJR Am J Roentgenol. 203(5):1047-1058, 2014
                                                          4. Meltzer, DE at al: Extradiskal pathology of temporomandibular joint: MR imaging and CT manifestations. Neurographics. 3:185-193, 2013
                                                          5. Magarelli N et al: Imaging of chondrocalcinosis: calcium pyrophosphate dihydrate (CPPD) crystal deposition disease -- imaging of common sites of involvement. Clin Exp Rheumatol. 30(1):118-25, 2012
                                                          6. Zweifel D et al: Tophaceuos calcium pyrophosphate dihydrate deposition disease of the temporomandibular joint: the preferential site? J Oral Maxillofac Surg. 70(1):60-7, 2012
                                                          7. Kamani T et al: Chondrocalcinosis of the temporomandibular joint: a rare but important diagnosis. Ear Nose Throat J. 88(9):E6-9, 2009
                                                          8. Naqvi AH et al: Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint - FNA findings and microanalysis. Cytojournal. 5:8, 2008
                                                          9. Reynolds JL et al: Tophaceous calcium pyrophosphate dihydrate deposition disease of the temporomandibular joint. J Rheumatol. 35(4):717-21, 2008
                                                          10. Rosenthal AK: Update in calcium deposition diseases. Curr Opin Rheumatol. 19(2):158-62, 2007
                                                          11. Marsot-Dupuch K et al: Massive calcium pyrophosphate dihydrate crystal deposition disease: a cause of pain of the temporomandibular joint. AJNR Am J Neuroradiol. 25(5):876-9, 2004
                                                          12. Aoyama S et al: Differential diagnosis of calcium pyrophosphate dihydrate deposition of the temporomandibular joint. Br J Oral Maxillofac Surg. 38(5):550-3, 2000
                                                          13. Srinivasan V et al: Calcium pyrophosphate deposition disease of the temporomandibular joint. J Neurol Surg Rep. 73(1):6-8, 2012