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Tracheobronchial Papillomatosis
Gerald F. Abbott, MD, FACR; Florian J. Fintelmann, MD, FRCPC; Brett W. Carter, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Recurrent respiratory papillomatosis (RRP)
            • Definitions

              • Airway nodules (papillomas) due to human papilloma virus (HPV) infection
                • Upper > lower airways
              • Invasive papillomatosis
                • Dissemination to lungs

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Jhun BW et al: The clinical, radiological, and bronchoscopic findings and outcomes in patients with benign tracheobronchial tumors. Yonsei Med J. 55(1):84-91, 2014
                                        2. Yu JP et al: Heterogeneous 18F-FDG uptake in recurrent respiratory papillomatosis. Clin Nucl Med. 38(5):387-9, 2013
                                        3. Colt HG et al: Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis. Laryngoscope. 120(3):468-72, 2010
                                        4. Marchiori E et al: Tracheobronchial papillomatosis with diffuse cavitary lung lesions. Pediatr Radiol. 40(7):1301-2; author reply 1303, 2010
                                        5. Prince JS et al: Nonneoplastic lesions of the tracheobronchial wall: radiologic findings with bronchoscopic correlation. Radiographics. 22 Spec No(S215-30, 2002
                                        6. Guillou L et al: Squamous cell carcinoma of the lung in a nonsmoking, nonirradiated patient with juvenile laryngotracheal papillomatosis. Evidence of human papillomavirus-11 DNA in both carcinoma and papillomas. Am J Surg Pathol. 15(9):891-8, 1991
                                        7. Kramer SS et al: Pulmonary manifestations of juvenile laryngotracheal papillomatosis. AJR Am J Roentgenol. 144(4):687-94, 1985
                                        8. Godwin JD et al: Multiple, thin-walled cystic lesions of the lung. AJR Am J Roentgenol. 135(3):593-604, 1980
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Recurrent respiratory papillomatosis (RRP)
                                                  • Definitions

                                                    • Airway nodules (papillomas) due to human papilloma virus (HPV) infection
                                                      • Upper > lower airways
                                                    • Invasive papillomatosis
                                                      • Dissemination to lungs

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Jhun BW et al: The clinical, radiological, and bronchoscopic findings and outcomes in patients with benign tracheobronchial tumors. Yonsei Med J. 55(1):84-91, 2014
                                                                              2. Yu JP et al: Heterogeneous 18F-FDG uptake in recurrent respiratory papillomatosis. Clin Nucl Med. 38(5):387-9, 2013
                                                                              3. Colt HG et al: Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis. Laryngoscope. 120(3):468-72, 2010
                                                                              4. Marchiori E et al: Tracheobronchial papillomatosis with diffuse cavitary lung lesions. Pediatr Radiol. 40(7):1301-2; author reply 1303, 2010
                                                                              5. Prince JS et al: Nonneoplastic lesions of the tracheobronchial wall: radiologic findings with bronchoscopic correlation. Radiographics. 22 Spec No(S215-30, 2002
                                                                              6. Guillou L et al: Squamous cell carcinoma of the lung in a nonsmoking, nonirradiated patient with juvenile laryngotracheal papillomatosis. Evidence of human papillomavirus-11 DNA in both carcinoma and papillomas. Am J Surg Pathol. 15(9):891-8, 1991
                                                                              7. Kramer SS et al: Pulmonary manifestations of juvenile laryngotracheal papillomatosis. AJR Am J Roentgenol. 144(4):687-94, 1985
                                                                              8. Godwin JD et al: Multiple, thin-walled cystic lesions of the lung. AJR Am J Roentgenol. 135(3):593-604, 1980