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Transient Bone Marrow Edema and Regional Migratory Osteoporosis
Cheryl A. Petersilge, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Transient bone marrow edema syndrome: Painful bone marrow edema centered around joints; of unknown etiology and self-limited
                • Transient regional osteoporosis (TRO): Likely subset of transient bone marrow edema syndrome that shows bone marrow edema and radiographic osteoporosis
                  • Regional migratory osteoporosis: TRO that shows migratory pattern
                  • Transient osteoporosis of hip (TOH): TRO, specifically of hip (most common location)

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • MR Findings

                    • Bone Scan Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Joshi V et al: Painless transient bone marrow edema syndrome in a pediatric patient. Skeletal Radiol. 43(11):1615-9, 2014
                                      2. Korompilias AV et al: Bone marrow edema syndrome. Skeletal Radiol. 38(5):425-36, 2009
                                      3. Roemer FW et al: MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis. Osteoarthritis Cartilage. 17(9):1115-31, 2009
                                      4. Hofmann S: The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr. 117(4):111-20, 2005
                                      5. Malizos KN et al: MR imaging findings in transient osteoporosis of the hip. Eur J Radiol. 50(3):238-44, 2004
                                      6. Vande Berg BC et al: Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology. 212(2):527-35, 1999
                                      7. McCarthy EF: The pathology of transient regional osteoporosis. Iowa Orthop J. 18:35-42, 1998
                                      8. Hayes CW et al: MR imaging of bone marrow edema pattern: transient osteoporosis, transient bone marrow edema syndrome, or osteonecrosis. Radiographics. 13(5):1001-11; discussion 1012, 1993
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Definitions

                                                  • Transient bone marrow edema syndrome: Painful bone marrow edema centered around joints; of unknown etiology and self-limited
                                                    • Transient regional osteoporosis (TRO): Likely subset of transient bone marrow edema syndrome that shows bone marrow edema and radiographic osteoporosis
                                                      • Regional migratory osteoporosis: TRO that shows migratory pattern
                                                      • Transient osteoporosis of hip (TOH): TRO, specifically of hip (most common location)

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Radiographic Findings

                                                      • MR Findings

                                                        • Bone Scan Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Joshi V et al: Painless transient bone marrow edema syndrome in a pediatric patient. Skeletal Radiol. 43(11):1615-9, 2014
                                                                          2. Korompilias AV et al: Bone marrow edema syndrome. Skeletal Radiol. 38(5):425-36, 2009
                                                                          3. Roemer FW et al: MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis. Osteoarthritis Cartilage. 17(9):1115-31, 2009
                                                                          4. Hofmann S: The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr. 117(4):111-20, 2005
                                                                          5. Malizos KN et al: MR imaging findings in transient osteoporosis of the hip. Eur J Radiol. 50(3):238-44, 2004
                                                                          6. Vande Berg BC et al: Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology. 212(2):527-35, 1999
                                                                          7. McCarthy EF: The pathology of transient regional osteoporosis. Iowa Orthop J. 18:35-42, 1998
                                                                          8. Hayes CW et al: MR imaging of bone marrow edema pattern: transient osteoporosis, transient bone marrow edema syndrome, or osteonecrosis. Radiographics. 13(5):1001-11; discussion 1012, 1993