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Musculoskeletal
Diagnosis
Non-Traumatic Disease
Bone Marrow Edema and Necrosis
Bone Marrow Edema
Transient Bone Marrow Edema and Regional Migratory Osteoporosis
Transient Bone Marrow Edema and Regional Migratory Osteoporosis
Cheryl A. Petersilge, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Transient bone marrow edema syndrome: Painful bone marrow edema centered around joints; of unknown etiology and self-limited
                • Transient regional osteoporosis (TRO): Likely subset of transient bone marrow edema syndrome that shows bone marrow edema and radiographic osteoporosis
                  • Regional migratory osteoporosis: TRO that shows migratory pattern
                  • Transient osteoporosis of hip (TOH): TRO, specifically of hip (most common location)

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • MR Findings

                    • Bone Scan Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Joshi V et al: Painless transient bone marrow edema syndrome in a pediatric patient. Skeletal Radiol. 43(11):1615-9, 2014
                                      2. Korompilias AV et al: Bone marrow edema syndrome. Skeletal Radiol. 38(5):425-36, 2009
                                      3. Roemer FW et al: MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis. Osteoarthritis Cartilage. 17(9):1115-31, 2009
                                      4. Hofmann S: The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr. 117(4):111-20, 2005
                                      5. Malizos KN et al: MR imaging findings in transient osteoporosis of the hip. Eur J Radiol. 50(3):238-44, 2004
                                      6. Vande Berg BC et al: Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology. 212(2):527-35, 1999
                                      7. McCarthy EF: The pathology of transient regional osteoporosis. Iowa Orthop J. 18:35-42, 1998
                                      8. Hayes CW et al: MR imaging of bone marrow edema pattern: transient osteoporosis, transient bone marrow edema syndrome, or osteonecrosis. Radiographics. 13(5):1001-11; discussion 1012, 1993
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Definitions

                                                  • Transient bone marrow edema syndrome: Painful bone marrow edema centered around joints; of unknown etiology and self-limited
                                                    • Transient regional osteoporosis (TRO): Likely subset of transient bone marrow edema syndrome that shows bone marrow edema and radiographic osteoporosis
                                                      • Regional migratory osteoporosis: TRO that shows migratory pattern
                                                      • Transient osteoporosis of hip (TOH): TRO, specifically of hip (most common location)

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Radiographic Findings

                                                      • MR Findings

                                                        • Bone Scan Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Joshi V et al: Painless transient bone marrow edema syndrome in a pediatric patient. Skeletal Radiol. 43(11):1615-9, 2014
                                                                          2. Korompilias AV et al: Bone marrow edema syndrome. Skeletal Radiol. 38(5):425-36, 2009
                                                                          3. Roemer FW et al: MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis. Osteoarthritis Cartilage. 17(9):1115-31, 2009
                                                                          4. Hofmann S: The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr. 117(4):111-20, 2005
                                                                          5. Malizos KN et al: MR imaging findings in transient osteoporosis of the hip. Eur J Radiol. 50(3):238-44, 2004
                                                                          6. Vande Berg BC et al: Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology. 212(2):527-35, 1999
                                                                          7. McCarthy EF: The pathology of transient regional osteoporosis. Iowa Orthop J. 18:35-42, 1998
                                                                          8. Hayes CW et al: MR imaging of bone marrow edema pattern: transient osteoporosis, transient bone marrow edema syndrome, or osteonecrosis. Radiographics. 13(5):1001-11; discussion 1012, 1993
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