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Transient Tachypnea of Newborn
Hank Baskin, MD; Randy R. Richardson, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Transient tachypnea of newborn (TTN)
          • Synonyms

            • Wet lung disease, retained fetal fluid
          • Definitions

            • Transient tachypnea occurs when there is delayed evacuation of fetal lung fluid, causing engorgement of pulmonary lymphatics & capillaries
              • Usually term infants
              • More common (3x) in those born by cesarean section
                • Normal thoracic compression that occurs during vaginal delivery is bypassed by cesarean section
              • Lack of normal breathing may occur with sedated infants

          IMAGING

          • General Features

            • Imaging Recommendations

              DIFFERENTIAL DIAGNOSIS

                PATHOLOGY

                • General Features

                  • Gross Pathologic & Surgical Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Image Interpretation Pearls

                              Selected References

                              1. Salama H et al: Transient tachypnea of the newborn: Is empiric antimicrobial therapy needed? J Neonatal Perinatal Med. 6(3):237-41, 2013
                              2. Costa S et al: Transient tachypnea of the newborn and congenital pneumonia: a comparative study. J Matern Fetal Neonatal Med. 25(7):992-4, 2012
                              3. Stroustrup A et al: Randomized controlled trial of restrictive fluid management in transient tachypnea of the newborn. J Pediatr. 160(1):38-43.e1, 2012
                              4. Zanardo V et al: Neonatal respiratory morbidity risk and mode of delivery at term: influence of timing of elective caesarean delivery. Acta Paediatr. 93(5):643-7, 2004
                              5. Kuhn JP et al: Caffey's Pediatric Diagnostic Imaging. 10th ed, vol 1. Philadelphia: Mosby. 3:72-3, 2004
                              6. Kugelman A et al: Familial neonatal pneumothorax associated with transient tachypnea of the newborn. Pediatr Pulmonol. 36(1):69-72, 2003
                              7. Lewis V et al: Furosemide for transient tachypnea of the newborn. Cochrane Database Syst Rev. (1):CD003064, 2002
                              8. Herting E et al: Surfactant treatment of neonates with respiratory failure and group B streptococcal infection. Members of the Collaborative European Multicenter Study Group. Pediatrics. 106(5):957-64; discussion 1135, 2000
                              9. Newman B: Imaging of medical disease of the newborn lung. Radiol Clin North Am. 37(6):1049-65, 1999
                              10. Cleveland RH: A radiologic update on medical diseases of the newborn chest. Pediatr Radiol. 25(8):631-7, 1995
                              11. Shaw D et al: Imaging Children. Edinburgh: Churchill Livingstone. 1-165, 1994
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Clinical Issues

                                    • Diagnostic Checklist

                                      TERMINOLOGY

                                      • Abbreviations

                                        • Transient tachypnea of newborn (TTN)
                                      • Synonyms

                                        • Wet lung disease, retained fetal fluid
                                      • Definitions

                                        • Transient tachypnea occurs when there is delayed evacuation of fetal lung fluid, causing engorgement of pulmonary lymphatics & capillaries
                                          • Usually term infants
                                          • More common (3x) in those born by cesarean section
                                            • Normal thoracic compression that occurs during vaginal delivery is bypassed by cesarean section
                                          • Lack of normal breathing may occur with sedated infants

                                      IMAGING

                                      • General Features

                                        • Imaging Recommendations

                                          DIFFERENTIAL DIAGNOSIS

                                            PATHOLOGY

                                            • General Features

                                              • Gross Pathologic & Surgical Features

                                                CLINICAL ISSUES

                                                • Presentation

                                                  • Demographics

                                                    • Natural History & Prognosis

                                                      • Treatment

                                                        DIAGNOSTIC CHECKLIST

                                                        • Image Interpretation Pearls

                                                          Selected References

                                                          1. Salama H et al: Transient tachypnea of the newborn: Is empiric antimicrobial therapy needed? J Neonatal Perinatal Med. 6(3):237-41, 2013
                                                          2. Costa S et al: Transient tachypnea of the newborn and congenital pneumonia: a comparative study. J Matern Fetal Neonatal Med. 25(7):992-4, 2012
                                                          3. Stroustrup A et al: Randomized controlled trial of restrictive fluid management in transient tachypnea of the newborn. J Pediatr. 160(1):38-43.e1, 2012
                                                          4. Zanardo V et al: Neonatal respiratory morbidity risk and mode of delivery at term: influence of timing of elective caesarean delivery. Acta Paediatr. 93(5):643-7, 2004
                                                          5. Kuhn JP et al: Caffey's Pediatric Diagnostic Imaging. 10th ed, vol 1. Philadelphia: Mosby. 3:72-3, 2004
                                                          6. Kugelman A et al: Familial neonatal pneumothorax associated with transient tachypnea of the newborn. Pediatr Pulmonol. 36(1):69-72, 2003
                                                          7. Lewis V et al: Furosemide for transient tachypnea of the newborn. Cochrane Database Syst Rev. (1):CD003064, 2002
                                                          8. Herting E et al: Surfactant treatment of neonates with respiratory failure and group B streptococcal infection. Members of the Collaborative European Multicenter Study Group. Pediatrics. 106(5):957-64; discussion 1135, 2000
                                                          9. Newman B: Imaging of medical disease of the newborn lung. Radiol Clin North Am. 37(6):1049-65, 1999
                                                          10. Cleveland RH: A radiologic update on medical diseases of the newborn chest. Pediatr Radiol. 25(8):631-7, 1995
                                                          11. Shaw D et al: Imaging Children. Edinburgh: Churchill Livingstone. 1-165, 1994