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Transient Tachypnea of Newborn
Hank Baskin, MD; Randy R. Richardson, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Transient tachypnea of newborn (TTN)
            • Synonyms

              • Wet lung disease, retained fetal fluid
            • Definitions

              • TTN occurs when evacuation of fetal lung fluid is delayed, causing engorgement of pulmonary lymphatics & capillaries
                • Usually occurs in term infants
                • More common (3x) in those born by cesarean section
                  • Normal thoracic compression that occurs during vaginal delivery is bypassed by cesarean section
                • Lack of normal breathing may occur with sedated infants

            IMAGING

            • General Features

              • Radiographic Findings

                • Ultrasonographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Alhassen Z et al: Recent advances in pathophysiology and management of transient tachypnea of newborn. J Perinatol. 41(1):6-16, 2021
                                    2. Gundogdu Z: Effect of sibship asthma on newborns with transient tachypnea of the newborn (TTN). Clin Respir J. 15(2):232-6, 2021
                                    3. Li CS et al: Prospective investigation of serial ultrasound for transient tachypnea of the newborn. Pediatr Neonatol. 62(1):64-9, 2021
                                    4. Singh Y et al: International evidence-based guidelines on point of care ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Crit Care. 24(1):65, 2020
                                    5. Gundogdu Z: New risk factors for transient tachypnea of the newborn and childhood asthma: a study of clinical data and a survey of parents. Cureus. 11(12):e6388, 2019
                                    6. Ibrahim M et al: Lung ultrasound in early diagnosis of neonatal transient tachypnea and its differentiation from other causes of neonatal respiratory distress. J Neonatal Perinatal Med. 11(3):281-7, 2018
                                    7. Copetti R et al: The 'double lung point': an ultrasound sign diagnostic of transient tachypnea of the newborn. Neonatology. 91(3):203-9, 2007
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Transient tachypnea of newborn (TTN)
                                              • Synonyms

                                                • Wet lung disease, retained fetal fluid
                                              • Definitions

                                                • TTN occurs when evacuation of fetal lung fluid is delayed, causing engorgement of pulmonary lymphatics & capillaries
                                                  • Usually occurs in term infants
                                                  • More common (3x) in those born by cesarean section
                                                    • Normal thoracic compression that occurs during vaginal delivery is bypassed by cesarean section
                                                  • Lack of normal breathing may occur with sedated infants

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • Ultrasonographic Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Alhassen Z et al: Recent advances in pathophysiology and management of transient tachypnea of newborn. J Perinatol. 41(1):6-16, 2021
                                                                      2. Gundogdu Z: Effect of sibship asthma on newborns with transient tachypnea of the newborn (TTN). Clin Respir J. 15(2):232-6, 2021
                                                                      3. Li CS et al: Prospective investigation of serial ultrasound for transient tachypnea of the newborn. Pediatr Neonatol. 62(1):64-9, 2021
                                                                      4. Singh Y et al: International evidence-based guidelines on point of care ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Crit Care. 24(1):65, 2020
                                                                      5. Gundogdu Z: New risk factors for transient tachypnea of the newborn and childhood asthma: a study of clinical data and a survey of parents. Cureus. 11(12):e6388, 2019
                                                                      6. Ibrahim M et al: Lung ultrasound in early diagnosis of neonatal transient tachypnea and its differentiation from other causes of neonatal respiratory distress. J Neonatal Perinatal Med. 11(3):281-7, 2018
                                                                      7. Copetti R et al: The 'double lung point': an ultrasound sign diagnostic of transient tachypnea of the newborn. Neonatology. 91(3):203-9, 2007