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Transitional Cell Carcinoma
Brad Perry, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Definitions

          • Transitional cell carcinoma (TCC), a.k.a. urothelial carcinoma
            • Arises from transitional epithelial cells lining urinary tract
            • Most common malignancy of urinary system
            • Usually involves urinary bladder but can arise from urethra, ureter, or renal pelvis

        IMAGING

        • General Features

          • Nuclear Medicine Findings

            • F-18 FDG PET/CT Findings

              • C-11 Acetate PET/CT Findings

                • MR Findings

                  • Imaging Recommendations

                    • Artifacts and Quality Control

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Ha HK et al: Diagnostic accuracy of F-18 FDG PET/CT for preoperative lymph node staging in newly diagnosed bladder cancer patients: A systematic review and meta-Analysis. Oncology. 95(1):31-8, 2018
                                      2. Razik A et al: PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art. Indian J Urol. 34(1):20-7, 2018
                                      3. Rais-Bahrami S et al: Contemporary role of advanced imaging for bladder cancer staging. Urol Oncol. 34(3):124-33, 2016
                                      4. Asai S et al: Fluorodeoxyglucose positron emission tomography/computed tomography for diagnosis of upper urinary tract urothelial carcinoma. Int J Clin Oncol. 20(5):1042-7, 2015
                                      5. Nayak B et al: Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel technique. Eur J Nucl Med Mol Imaging. 40(3):386-93, 2013
                                      6. Anjos DA et al: 18F-FDG PET/CT delayed images after diuretic for restaging invasive bladder cancer. J Nucl Med. 48(5):764-70, 2007
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Definitions

                                              • Transitional cell carcinoma (TCC), a.k.a. urothelial carcinoma
                                                • Arises from transitional epithelial cells lining urinary tract
                                                • Most common malignancy of urinary system
                                                • Usually involves urinary bladder but can arise from urethra, ureter, or renal pelvis

                                            IMAGING

                                            • General Features

                                              • Nuclear Medicine Findings

                                                • F-18 FDG PET/CT Findings

                                                  • C-11 Acetate PET/CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        • Artifacts and Quality Control

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Ha HK et al: Diagnostic accuracy of F-18 FDG PET/CT for preoperative lymph node staging in newly diagnosed bladder cancer patients: A systematic review and meta-Analysis. Oncology. 95(1):31-8, 2018
                                                                          2. Razik A et al: PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art. Indian J Urol. 34(1):20-7, 2018
                                                                          3. Rais-Bahrami S et al: Contemporary role of advanced imaging for bladder cancer staging. Urol Oncol. 34(3):124-33, 2016
                                                                          4. Asai S et al: Fluorodeoxyglucose positron emission tomography/computed tomography for diagnosis of upper urinary tract urothelial carcinoma. Int J Clin Oncol. 20(5):1042-7, 2015
                                                                          5. Nayak B et al: Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel technique. Eur J Nucl Med Mol Imaging. 40(3):386-93, 2013
                                                                          6. Anjos DA et al: 18F-FDG PET/CT delayed images after diuretic for restaging invasive bladder cancer. J Nucl Med. 48(5):764-70, 2007