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Transposition of the Great Arteries
Michael D. Puchalski, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Transposition of great arteries (TGA)
              • D-transposition
              • Dextrotransposition
            • Congenitally corrected transposition of great arteries (CTGA)
              • L-transposition
              • Ventricular inversion
              • Levotransposition
          • Definitions

            • TGA: Ventriculoarterial (VA) discordance
              • Aorta arises from right ventricle (RV)
              • Pulmonary artery (PA) arises from left ventricle (LV)
              • Further distinguished by presence/absence of ventricular septal defect (VSD)
            • CTGA: Atrioventricular (AV) and VA discordance
              • Right atrium → LV → PA
              • Left atrium → RV → aorta

          IMAGING

          • General Features

            • Echocardiographic Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Staging, Grading, & Classification

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Brandt JS et al: Utility of a single 3-vessel view in the evaluation of the ventricular outflow tracts. J Ultrasound Med. 34(8):1415-21, 2015
                                  2. Debost-Legrand A et al: Impact of prenatal diagnosis on the outcome of patients with a transposition of great arteries: A 24-year population-based study. Birth Defects Res A Clin Mol Teratol. 106(3):178-84, 2015
                                  3. Escobar-Diaz MC et al: Prenatal diagnosis of transposition of the great arteries over a 20-year period: improved but imperfect. Ultrasound Obstet Gynecol. 45(6):678-82, 2015
                                  4. Palatnik A et al: Is the "I-sign" in the 3-vessel and trachea view a valid tool for prenatal diagnosis of D-transposition of the great arteries? J Ultrasound Med. 34(7):1329-35, 2015
                                  5. Wolter A et al: Fetal cardiac axis in fetuses with conotruncal anomalies. Ultraschall Med. ePub, 2015
                                  6. Villafañe J et al: D-transposition of the great arteries: the current era of the arterial switch operation. J Am Coll Cardiol. 64(5):498-511, 2014
                                  7. Hörer J et al: Improvement in long-term survival after hospital discharge but not in freedom from reoperation after the change from atrial to arterial switch for transposition of the great arteries. J Thorac Cardiovasc Surg. 137(2):347-54, 2009
                                  8. Langley SM et al: Midterm results after restoration of the morphologically left ventricle to the systemic circulation in patients with congenitally corrected transposition of the great arteries. J Thorac Cardiovasc Surg. 125(6):1229-41, 2003
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Clinical Issues

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Synonyms

                                            • Transposition of great arteries (TGA)
                                              • D-transposition
                                              • Dextrotransposition
                                            • Congenitally corrected transposition of great arteries (CTGA)
                                              • L-transposition
                                              • Ventricular inversion
                                              • Levotransposition
                                          • Definitions

                                            • TGA: Ventriculoarterial (VA) discordance
                                              • Aorta arises from right ventricle (RV)
                                              • Pulmonary artery (PA) arises from left ventricle (LV)
                                              • Further distinguished by presence/absence of ventricular septal defect (VSD)
                                            • CTGA: Atrioventricular (AV) and VA discordance
                                              • Right atrium → LV → PA
                                              • Left atrium → RV → aorta

                                          IMAGING

                                          • General Features

                                            • Echocardiographic Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Staging, Grading, & Classification

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Consider

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Brandt JS et al: Utility of a single 3-vessel view in the evaluation of the ventricular outflow tracts. J Ultrasound Med. 34(8):1415-21, 2015
                                                                  2. Debost-Legrand A et al: Impact of prenatal diagnosis on the outcome of patients with a transposition of great arteries: A 24-year population-based study. Birth Defects Res A Clin Mol Teratol. 106(3):178-84, 2015
                                                                  3. Escobar-Diaz MC et al: Prenatal diagnosis of transposition of the great arteries over a 20-year period: improved but imperfect. Ultrasound Obstet Gynecol. 45(6):678-82, 2015
                                                                  4. Palatnik A et al: Is the "I-sign" in the 3-vessel and trachea view a valid tool for prenatal diagnosis of D-transposition of the great arteries? J Ultrasound Med. 34(7):1329-35, 2015
                                                                  5. Wolter A et al: Fetal cardiac axis in fetuses with conotruncal anomalies. Ultraschall Med. ePub, 2015
                                                                  6. Villafañe J et al: D-transposition of the great arteries: the current era of the arterial switch operation. J Am Coll Cardiol. 64(5):498-511, 2014
                                                                  7. Hörer J et al: Improvement in long-term survival after hospital discharge but not in freedom from reoperation after the change from atrial to arterial switch for transposition of the great arteries. J Thorac Cardiovasc Surg. 137(2):347-54, 2009
                                                                  8. Langley SM et al: Midterm results after restoration of the morphologically left ventricle to the systemic circulation in patients with congenitally corrected transposition of the great arteries. J Thorac Cardiovasc Surg. 125(6):1229-41, 2003