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Musculoskeletal
Diagnosis
Non-Trauma
Bone Tumors and Tumor-Like Conditions
Tumor-Like Conditions
Trevor Fairbank Disease
Trevor Fairbank Disease
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR; Eric Walker, MD, MHA, FACR, FACHE
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Dysplasia epiphysealis hemimelica, Trevor disease, Fairbank disease

        • Definitions

          • Osteochondroma-like lesion involving 1 or multiple epiphyses
          • Though genetically different than osteochondromas, lesions of Trevor Fairbank have same imaging features, development, and implications other than location

        IMAGING

        • General Features

          • Radiographic Findings

            • MR Findings

              DIFFERENTIAL DIAGNOSIS

                PATHOLOGY

                • General Features

                  • Gross Pathologic & Surgical Features

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Treatment

                            Selected References

                            1. Degnan AJ et al: More than epiphyseal osteochondromas: updated understanding of imaging findings in dysplasia epiphysealis hemimelica (Trevor disease). AJR Am J Roentgenol. 211(4):910-9, 2018
                            2. Stevens J et al: Dysplasia epiphysealis hemimelica: a histological comparative study with osteochondromas. J Child Orthop. 11(3):160-8, 2017
                            3. Wheeldon G et al: Dysplasia epiphysealis hemimelica of the knee: an unusual presentation with intra-articular loose bodies and literature review. J Pediatr Orthop B. 24(4):326-9, 2015
                            4. Arealis G et al: Trevor's disease: a literature review regarding classification, treatment, and prognosis apropos of a case. Case Rep Orthop. 2014:940360, 2014
                            5. Bosch C et al: Diagnosis and surgical treatment of dysplasia epiphysealis hemimelica. A report of nine cases. Orthop Traumatol Surg Res. 100(8):941-6, 2014
                            6. Tyler PA et al: Imaging of dysplasia epiphysealis hemimelica (Trevor's disease). Clin Radiol. 68(4):415-21, 2013
                            7. Struijs PA et al: Treatment of dysplasia epiphysealis hemimelica: a systematic review of published reports and a report of seven patients. J Foot Ankle Surg. 51(5):620-6, 2012
                            8. Bahk WJ et al: Dysplasia epiphysealis hemimelica: radiographic and magnetic resonance imaging features and clinical outcome of complete and incomplete resection. Skeletal Radiol. 39(1):85-90, 2010
                            9. Glick R et al: Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones. Hum Pathol. 38(8):1265-72, 2007
                            10. Wenger DR et al: Evaluation, imaging, histology and operative treatment for dysplasia epiphysealis hemimelica (Trevor disease) of the acetabulum: a case report and review. Iowa Orthop J. 25:60-5, 2005
                            11. Schrot RJ et al: Trevor disease of the spine. Case report. J Neurosurg Spine. 1(3):342-6, 2004
                            12. Oestreich AE et al: Both Trevor and Ollier disease limited to one upper extremity. Skeletal Radiol. 31(4):230-4, 2002
                            13. Murphey MD et al: Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 20(5):1407-34, 2000
                            14. Graves SC et al: Dysplasia epiphysealis hemimelica (Trevor disease) presenting as peroneal spastic flatfoot deformity: a case report. Foot Ankle. 12(1):55-8, 1991
                            15. Schmidt MB et al: Radiologic case study. Trevor disease: dysplasia epiphysealis hemimelica. Orthopedics. 17(7):645, 649-53, 1994
                            16. Greenspan A et al: Mixed sclerosing bone dysplasia coexisting with dysplasia epiphysealis hemimelica (Trevor-Fairbank disease). Skeletal Radiol. 15(6):452-4, 1986
                            17. Azouz EM et al: The variable manifestations of dysplasia epiphysealis hemimelica. Pediatr Radiol. 15(1):44-9, 1985
                            18. Azouz EM et al: Upper extremity involvement in Trevor disease. J Can Assoc Radiol. 35(2):209-11, 1984
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Terminology

                              • Imaging

                                • Clinical Issues

                                  TERMINOLOGY

                                  • Synonyms

                                    • Dysplasia epiphysealis hemimelica, Trevor disease, Fairbank disease

                                  • Definitions

                                    • Osteochondroma-like lesion involving 1 or multiple epiphyses
                                    • Though genetically different than osteochondromas, lesions of Trevor Fairbank have same imaging features, development, and implications other than location

                                  IMAGING

                                  • General Features

                                    • Radiographic Findings

                                      • MR Findings

                                        DIFFERENTIAL DIAGNOSIS

                                          PATHOLOGY

                                          • General Features

                                            • Gross Pathologic & Surgical Features

                                              • Microscopic Features

                                                CLINICAL ISSUES

                                                • Presentation

                                                  • Demographics

                                                    • Treatment

                                                      Selected References

                                                      1. Degnan AJ et al: More than epiphyseal osteochondromas: updated understanding of imaging findings in dysplasia epiphysealis hemimelica (Trevor disease). AJR Am J Roentgenol. 211(4):910-9, 2018
                                                      2. Stevens J et al: Dysplasia epiphysealis hemimelica: a histological comparative study with osteochondromas. J Child Orthop. 11(3):160-8, 2017
                                                      3. Wheeldon G et al: Dysplasia epiphysealis hemimelica of the knee: an unusual presentation with intra-articular loose bodies and literature review. J Pediatr Orthop B. 24(4):326-9, 2015
                                                      4. Arealis G et al: Trevor's disease: a literature review regarding classification, treatment, and prognosis apropos of a case. Case Rep Orthop. 2014:940360, 2014
                                                      5. Bosch C et al: Diagnosis and surgical treatment of dysplasia epiphysealis hemimelica. A report of nine cases. Orthop Traumatol Surg Res. 100(8):941-6, 2014
                                                      6. Tyler PA et al: Imaging of dysplasia epiphysealis hemimelica (Trevor's disease). Clin Radiol. 68(4):415-21, 2013
                                                      7. Struijs PA et al: Treatment of dysplasia epiphysealis hemimelica: a systematic review of published reports and a report of seven patients. J Foot Ankle Surg. 51(5):620-6, 2012
                                                      8. Bahk WJ et al: Dysplasia epiphysealis hemimelica: radiographic and magnetic resonance imaging features and clinical outcome of complete and incomplete resection. Skeletal Radiol. 39(1):85-90, 2010
                                                      9. Glick R et al: Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones. Hum Pathol. 38(8):1265-72, 2007
                                                      10. Wenger DR et al: Evaluation, imaging, histology and operative treatment for dysplasia epiphysealis hemimelica (Trevor disease) of the acetabulum: a case report and review. Iowa Orthop J. 25:60-5, 2005
                                                      11. Schrot RJ et al: Trevor disease of the spine. Case report. J Neurosurg Spine. 1(3):342-6, 2004
                                                      12. Oestreich AE et al: Both Trevor and Ollier disease limited to one upper extremity. Skeletal Radiol. 31(4):230-4, 2002
                                                      13. Murphey MD et al: Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 20(5):1407-34, 2000
                                                      14. Graves SC et al: Dysplasia epiphysealis hemimelica (Trevor disease) presenting as peroneal spastic flatfoot deformity: a case report. Foot Ankle. 12(1):55-8, 1991
                                                      15. Schmidt MB et al: Radiologic case study. Trevor disease: dysplasia epiphysealis hemimelica. Orthopedics. 17(7):645, 649-53, 1994
                                                      16. Greenspan A et al: Mixed sclerosing bone dysplasia coexisting with dysplasia epiphysealis hemimelica (Trevor-Fairbank disease). Skeletal Radiol. 15(6):452-4, 1986
                                                      17. Azouz EM et al: The variable manifestations of dysplasia epiphysealis hemimelica. Pediatr Radiol. 15(1):44-9, 1985
                                                      18. Azouz EM et al: Upper extremity involvement in Trevor disease. J Can Assoc Radiol. 35(2):209-11, 1984