Tuberosis sclerosis complex (TSC): multiorgan genetic neurocutaneous syndrome characterized by development of hamartomas
IMAGING
Radiographic Findings
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Darling TN et al: TSC1 and TSC2 genotype in tuberous sclerosis complex: are other manifestations of this multisystem disease affected by genotype? Ann Am Thorac Soc. 18(5):775-7, 2021
Brakemeier S et al: Sclerotic bone lesions as a potential imaging biomarker for the diagnosis of tuberous sclerosis complex. Sci Rep. 8(1):953, 2018
von Ranke FM et al: Imaging of tuberous sclerosis complex: a pictorial review. Radiol Bras. 50(1):48-54, 2017
Boronat S et al: Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex. Pediatr Radiol. 46(5):689-94, 2016
Lew PP et al: Imaging of disorders affecting the bone and skin. Radiographics. 34(1):197-216, 2014
Krueger DA et al: Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol. 49(4):255-65, 2013
Avila NA et al: CT of sclerotic bone lesions: imaging features differentiating tuberous sclerosis complex with lymphangioleiomyomatosis from sporadic lymphangioleiomymatosis. Radiology. 254(3):851-7, 2010
Ess KC: Tuberous sclerosis complex: a brave new world? Curr Opin Neurol. 23(2):189-93, 2010
Adriaensen ME et al: Fatty foci in the myocardium in patients with tuberous sclerosis complex: common finding at CT. Radiology. 253(2):359-63, 2009
Bonsib SM: Renal cystic diseases and renal neoplasms: a mini-review. Clin J Am Soc Nephrol. 4(12):1998-2007, 2009
Napolioni V et al: Genetics and molecular biology of tuberous sclerosis complex. Curr Genomics. 9(7):475-87, 2008
Umeoka S et al: Pictorial review of tuberous sclerosis in various organs. Radiographics. 28(7):e32, 2008
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References
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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Definitions
Tuberosis sclerosis complex (TSC): multiorgan genetic neurocutaneous syndrome characterized by development of hamartomas
IMAGING
Radiographic Findings
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Darling TN et al: TSC1 and TSC2 genotype in tuberous sclerosis complex: are other manifestations of this multisystem disease affected by genotype? Ann Am Thorac Soc. 18(5):775-7, 2021
Brakemeier S et al: Sclerotic bone lesions as a potential imaging biomarker for the diagnosis of tuberous sclerosis complex. Sci Rep. 8(1):953, 2018
von Ranke FM et al: Imaging of tuberous sclerosis complex: a pictorial review. Radiol Bras. 50(1):48-54, 2017
Boronat S et al: Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex. Pediatr Radiol. 46(5):689-94, 2016
Lew PP et al: Imaging of disorders affecting the bone and skin. Radiographics. 34(1):197-216, 2014
Krueger DA et al: Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol. 49(4):255-65, 2013
Avila NA et al: CT of sclerotic bone lesions: imaging features differentiating tuberous sclerosis complex with lymphangioleiomyomatosis from sporadic lymphangioleiomymatosis. Radiology. 254(3):851-7, 2010
Ess KC: Tuberous sclerosis complex: a brave new world? Curr Opin Neurol. 23(2):189-93, 2010
Adriaensen ME et al: Fatty foci in the myocardium in patients with tuberous sclerosis complex: common finding at CT. Radiology. 253(2):359-63, 2009
Bonsib SM: Renal cystic diseases and renal neoplasms: a mini-review. Clin J Am Soc Nephrol. 4(12):1998-2007, 2009
Napolioni V et al: Genetics and molecular biology of tuberous sclerosis complex. Curr Genomics. 9(7):475-87, 2008
Umeoka S et al: Pictorial review of tuberous sclerosis in various organs. Radiographics. 28(7):e32, 2008
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