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Breast
Histopathologic Diagnoses
Benign Lesions
Tubular Adenoma and Nipple Adenoma
Tubular Adenoma and Nipple Adenoma
Nicole S. Winkler, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Tubular adenoma: Pure adenoma, adenofibroma
              • Nipple adenoma: Papillary adenoma of nipple, erosive adenomatosis, papillomatosis of nipple

            • Definitions

              • Tubular adenoma (TA): Uncommon benign breast mass due to localized proliferation of compact, well-formed tubular structures with discrete tumor border; variant of fibroadenoma (FA)
              • Nipple adenoma (NA): Uncommon benign nipple epithelial proliferative lesion involving duct orifices

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • Nuclear Medicine Findings

                    • MR Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Lee C et al: Case Report of a synchronous nipple adenoma and breast carcinoma with current multi-modality radiologic imaging. Breast J. 22(1):105-10, 2016
                                      2. Spohn GP et al: Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. BMC Dermatol. 16(1):4, 2016
                                      3. Eusebi V et al. Tumours of the Nipple. In: Lakhani SR et al. WHO Classification of Tumours of the Breast. 4th Edition Lyon, France: IARC; 2012
                                      4. Spyropoulou GA et al: Rare benign tumours of the nipple. J Eur Acad Dermatol Venereol. 29(1):7-13, 2015
                                      5. Saimura M et al: Ductal carcinoma in situ arising in tubular adenoma of the breast. Breast Cancer. Epub ahead of print, 2012
                                      6. Rao P et al: Male nipple adenoma with DCIS followed 9 years later by invasive carcinoma. Breast J. 16(3):317-8, 2010
                                      7. Sarica O et al: Evaluation of nipple-areola complex with ultrasonography and magnetic resonance imaging. J Comput Assist Tomogr. 34(4):575-86, 2010
                                      8. Tao W et al: Nipple adenoma in an adolescent. Pediatr Dermatol. 27(4):399-401, 2010
                                      9. Clune JE et al: Nipple adenoma in infancy. J Pediatr Surg. 44(11):2219-22, 2009
                                      10. Goto M et al: MR imaging of tubular adenoma of breast associated with lactating change. Breast J. 15(5):536-7, 2009
                                      11. Irshad A et al: Rare breast lesions: correlation of imaging and histologic features with WHO classification. Radiographics. 28(5):1399-414, 2008
                                      12. Kono S et al: Nipple adenoma found in a mastectomy specimen: report of a case with special regard to the proliferation pattern. Breast Cancer. 14(2):234-8, 2007
                                      13. Soo MS et al: Tubular adenomas of the breast: imaging findings with histologic correlation. AJR Am J Roentgenol. 174(3):757-61, 2000
                                      14. Tavassoli FA: Pathology of the Breast. 2nd ed. Stamford: Appleton & Lange. 115–204, 1999
                                      15. Shet TM et al: Aspiration cytology of tubular adenomas of the breast. An analysis of eight cases. Acta Cytol. 42(3):657-62, 1998
                                      16. Liu K et al: Cytologic features of a combined tubular adenoma and fibroadenoma of the breast. Diagn Cytopathol. 16(2):184-6, 1997
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Tubular adenoma: Pure adenoma, adenofibroma
                                                  • Nipple adenoma: Papillary adenoma of nipple, erosive adenomatosis, papillomatosis of nipple

                                                • Definitions

                                                  • Tubular adenoma (TA): Uncommon benign breast mass due to localized proliferation of compact, well-formed tubular structures with discrete tumor border; variant of fibroadenoma (FA)
                                                  • Nipple adenoma (NA): Uncommon benign nipple epithelial proliferative lesion involving duct orifices

                                                IMAGING

                                                • General Features

                                                  • Mammographic Findings

                                                    • Ultrasonographic Findings

                                                      • Nuclear Medicine Findings

                                                        • MR Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Lee C et al: Case Report of a synchronous nipple adenoma and breast carcinoma with current multi-modality radiologic imaging. Breast J. 22(1):105-10, 2016
                                                                          2. Spohn GP et al: Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. BMC Dermatol. 16(1):4, 2016
                                                                          3. Eusebi V et al. Tumours of the Nipple. In: Lakhani SR et al. WHO Classification of Tumours of the Breast. 4th Edition Lyon, France: IARC; 2012
                                                                          4. Spyropoulou GA et al: Rare benign tumours of the nipple. J Eur Acad Dermatol Venereol. 29(1):7-13, 2015
                                                                          5. Saimura M et al: Ductal carcinoma in situ arising in tubular adenoma of the breast. Breast Cancer. Epub ahead of print, 2012
                                                                          6. Rao P et al: Male nipple adenoma with DCIS followed 9 years later by invasive carcinoma. Breast J. 16(3):317-8, 2010
                                                                          7. Sarica O et al: Evaluation of nipple-areola complex with ultrasonography and magnetic resonance imaging. J Comput Assist Tomogr. 34(4):575-86, 2010
                                                                          8. Tao W et al: Nipple adenoma in an adolescent. Pediatr Dermatol. 27(4):399-401, 2010
                                                                          9. Clune JE et al: Nipple adenoma in infancy. J Pediatr Surg. 44(11):2219-22, 2009
                                                                          10. Goto M et al: MR imaging of tubular adenoma of breast associated with lactating change. Breast J. 15(5):536-7, 2009
                                                                          11. Irshad A et al: Rare breast lesions: correlation of imaging and histologic features with WHO classification. Radiographics. 28(5):1399-414, 2008
                                                                          12. Kono S et al: Nipple adenoma found in a mastectomy specimen: report of a case with special regard to the proliferation pattern. Breast Cancer. 14(2):234-8, 2007
                                                                          13. Soo MS et al: Tubular adenomas of the breast: imaging findings with histologic correlation. AJR Am J Roentgenol. 174(3):757-61, 2000
                                                                          14. Tavassoli FA: Pathology of the Breast. 2nd ed. Stamford: Appleton & Lange. 115–204, 1999
                                                                          15. Shet TM et al: Aspiration cytology of tubular adenomas of the breast. An analysis of eight cases. Acta Cytol. 42(3):657-62, 1998
                                                                          16. Liu K et al: Cytologic features of a combined tubular adenoma and fibroadenoma of the breast. Diagn Cytopathol. 16(2):184-6, 1997