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Terminology
Imaging
Top Differential Diagnoses
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TERMINOLOGY
Definitions
- Tubular carcinoma (TC) = cribriform carcinoma: Well-differentiated invasive ductal carcinoma (IDC) composed of tubular structures with single epithelial layer (lacking myoepithelium) and open lumina
- Pure TC: Proportion of tubular structures ≥ 90%
- IDC with tubular features = IDC with ≥ 50-89% tubular pattern = "mixed" TC
- Tubulolobular carcinoma (TLC): Morphologically distinct, rare type of IDC with ≥ 75% of tumor consisting of well-formed tubules and single-file, dyscohesive cells (retaining E-cadherin)
- Variable proportions: Predominantly tubular in 27%; equal in 27%; predominantly lobular in 47%
- Tubular carcinoma (TC) = cribriform carcinoma: Well-differentiated invasive ductal carcinoma (IDC) composed of tubular structures with single epithelial layer (lacking myoepithelium) and open lumina
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Selected References
- Chen JX et al: The effects of postoperative radiotherapy on survival outcomes in patients under 65 with estrogen receptor positive tubular breast carcinoma. Radiat Oncol. 13(1):226, 2018
- Lee SJ et al: Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer. Medicine (Baltimore). 97(43):e12840, 2018
- Poirier É et al: Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast. J Surg Oncol. 117(6):1137-43, 2018
- Sun JY et al: Tubular carcinomas of the breast: an epidemiologic study. Future Oncol. ePub, 2018
- Wu SG et al: Omission of postoperative radiotherapy in women aged 65 years or older with tubular carcinoma of the breast after breast-conserving surgery. Front Oncol. 8:190, 2018
- Zhang WW et al: Clinicopathologic characteristics and clinical outcomes of pure type and mixed type of tubular carcinoma of the breast: a single-institution cohort study. Cancer Manag Res. 10:4509-15, 2018
- Boyan W et al: Tubular carcinoma of the breast: a single institution's experience of a favorable prognosis. Am Surg. 82(6):505-9, 2016
- Stolnicu S et al: Even small pure tubular carcinoma of the breast (stage T1a and T1b) can be associated with lymph node metastases - The U T MD Anderson Cancer Center experience. Eur J Surg Oncol. 42(6):911-2, 2016
- Lea V et al: Tubular carcinoma of the breast: axillary involvement and prognostic factors. ANZ J Surg. 85(6):448-51, 2015
- Munzone E et al: Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial. Ann Oncol. 26(12):2442-9, 2015
- Romano AM et al: Tubular carcinoma of the breast: institutional and SEER database analysis supporting a unique classification. Breast Dis. 35(2):103-11, 2015
- Fritz P et al: Tubular breast cancer. A retrospective study. Anticancer Res. 34(7):3647-56, 2014
- Jorns JM et al: Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med. 138(11):1507-13, 2014
- Dejode M et al: Pure tubular carcinoma of the breast and sentinel lymph node biopsy: a retrospective multi-institutional study of 234 cases. Eur J Surg Oncol. 39(3):248-54, 2013
- Min Y et al: Tubular carcinoma of the breast: clinicopathologic features and survival outcome compared with ductal carcinoma in situ. J Breast Cancer. 16(4):404-9, 2013
- Bargalló X et al: Mammographic features of screening detected pT1 (a-b) invasive breast cancer using BI-RADS lexicon. Eur J Radiol. 81(10):2620-6, 2012
- Groves AM et al: Defining the role of PET-CT in staging early breast cancer. Oncologist. 17(5):613-9, 2012
- Linda A et al: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol. 75(2):178-84, 2010
- Manfrin E et al: Cancer size, histotype, and cellular grade may limit the success of fine-needle aspiration cytology for screen-detected breast carcinoma. Cancer. 117(6):491-9, 2009
- Esposito NN et al: The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol. 20(1):130-8, 2007
- Leikola J et al: The prevalence of axillary lymph-node metastases in patients with pure tubular carcinoma of the breast and sentinel node biopsy. Eur J Surg Oncol. 32(5):488-91, 2006
- Marchiò C et al: A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling. Histopathology. 48(5):556-62, 2006
- Fernandez-Aguilar S et al: Is complete axillary lymph node dissection neccessary in T1 stage invasive pure tubular carcinomas of the breast? Breast. 14(4):325-8, 2005
- Khirwadkar N et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 49(3):344-5, 2005
- Leonard CE et al: Excision only for tubular carcinoma of the breast. Breast J. 11(2):129-33, 2005
- Livi L et al: Tubular carcinoma of the breast: outcome and loco-regional recurrence in 307 patients. Eur J Surg Oncol. 31(1):9-12, 2005
- Sullivan T et al: Tubular carcinoma of the breast: a retrospective analysis and review of the literature. Breast Cancer Res Treat. 93(3):199-205, 2005
- Goldstein NS et al: Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients. Am J Clin Pathol. 122(5):728-39, 2004
- Cabral AH et al: Tubular carcinoma of the breast: an institutional experience and review of the literature. Breast J. 9(4):298-301, 2003
- Holland DW et al: Tubular breast cancer experience at Washington University: a review of the literature. Clin Breast Cancer. 2(3):210-4, 2001
- Kader HA et al: Tubular carcinoma of the breast: a population-based study of nodal metastases at presentation and of patterns of relapse. Breast J. 7(1):8-13, 2001
- Wurdinger S et al: False-negative findings of malignant breast lesions on preoperative magnetic resonance mammography. Breast. 10(2):131-9, 2001
- Sheppard DG et al: Tubular carcinoma of the breast: mammographic and sonographic features. AJR Am J Roentgenol. 174(1):253-7, 2000
- Mitnick JS et al: Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AJR Am J Roentgenol. 172(2):319-23, 1999
- Green I et al: A comparative study of pure tubular and tubulolobular carcinoma of the breast. Am J Surg Pathol. 21:653-7, 1997
- Gupta RK et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 41(4):1139-43, 1997
- McBoyle MF et al: Tubular carcinoma of the breast: an institutional review. Am Surg. 63(7):639-44; discussion 644-5, 1997
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Tubular carcinoma (TC) = cribriform carcinoma: Well-differentiated invasive ductal carcinoma (IDC) composed of tubular structures with single epithelial layer (lacking myoepithelium) and open lumina
- Pure TC: Proportion of tubular structures ≥ 90%
- IDC with tubular features = IDC with ≥ 50-89% tubular pattern = "mixed" TC
- Tubulolobular carcinoma (TLC): Morphologically distinct, rare type of IDC with ≥ 75% of tumor consisting of well-formed tubules and single-file, dyscohesive cells (retaining E-cadherin)
- Variable proportions: Predominantly tubular in 27%; equal in 27%; predominantly lobular in 47%
- Tubular carcinoma (TC) = cribriform carcinoma: Well-differentiated invasive ductal carcinoma (IDC) composed of tubular structures with single epithelial layer (lacking myoepithelium) and open lumina
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Chen JX et al: The effects of postoperative radiotherapy on survival outcomes in patients under 65 with estrogen receptor positive tubular breast carcinoma. Radiat Oncol. 13(1):226, 2018
- Lee SJ et al: Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer. Medicine (Baltimore). 97(43):e12840, 2018
- Poirier É et al: Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast. J Surg Oncol. 117(6):1137-43, 2018
- Sun JY et al: Tubular carcinomas of the breast: an epidemiologic study. Future Oncol. ePub, 2018
- Wu SG et al: Omission of postoperative radiotherapy in women aged 65 years or older with tubular carcinoma of the breast after breast-conserving surgery. Front Oncol. 8:190, 2018
- Zhang WW et al: Clinicopathologic characteristics and clinical outcomes of pure type and mixed type of tubular carcinoma of the breast: a single-institution cohort study. Cancer Manag Res. 10:4509-15, 2018
- Boyan W et al: Tubular carcinoma of the breast: a single institution's experience of a favorable prognosis. Am Surg. 82(6):505-9, 2016
- Stolnicu S et al: Even small pure tubular carcinoma of the breast (stage T1a and T1b) can be associated with lymph node metastases - The U T MD Anderson Cancer Center experience. Eur J Surg Oncol. 42(6):911-2, 2016
- Lea V et al: Tubular carcinoma of the breast: axillary involvement and prognostic factors. ANZ J Surg. 85(6):448-51, 2015
- Munzone E et al: Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial. Ann Oncol. 26(12):2442-9, 2015
- Romano AM et al: Tubular carcinoma of the breast: institutional and SEER database analysis supporting a unique classification. Breast Dis. 35(2):103-11, 2015
- Fritz P et al: Tubular breast cancer. A retrospective study. Anticancer Res. 34(7):3647-56, 2014
- Jorns JM et al: Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med. 138(11):1507-13, 2014
- Dejode M et al: Pure tubular carcinoma of the breast and sentinel lymph node biopsy: a retrospective multi-institutional study of 234 cases. Eur J Surg Oncol. 39(3):248-54, 2013
- Min Y et al: Tubular carcinoma of the breast: clinicopathologic features and survival outcome compared with ductal carcinoma in situ. J Breast Cancer. 16(4):404-9, 2013
- Bargalló X et al: Mammographic features of screening detected pT1 (a-b) invasive breast cancer using BI-RADS lexicon. Eur J Radiol. 81(10):2620-6, 2012
- Groves AM et al: Defining the role of PET-CT in staging early breast cancer. Oncologist. 17(5):613-9, 2012
- Linda A et al: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol. 75(2):178-84, 2010
- Manfrin E et al: Cancer size, histotype, and cellular grade may limit the success of fine-needle aspiration cytology for screen-detected breast carcinoma. Cancer. 117(6):491-9, 2009
- Esposito NN et al: The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol. 20(1):130-8, 2007
- Leikola J et al: The prevalence of axillary lymph-node metastases in patients with pure tubular carcinoma of the breast and sentinel node biopsy. Eur J Surg Oncol. 32(5):488-91, 2006
- Marchiò C et al: A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling. Histopathology. 48(5):556-62, 2006
- Fernandez-Aguilar S et al: Is complete axillary lymph node dissection neccessary in T1 stage invasive pure tubular carcinomas of the breast? Breast. 14(4):325-8, 2005
- Khirwadkar N et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 49(3):344-5, 2005
- Leonard CE et al: Excision only for tubular carcinoma of the breast. Breast J. 11(2):129-33, 2005
- Livi L et al: Tubular carcinoma of the breast: outcome and loco-regional recurrence in 307 patients. Eur J Surg Oncol. 31(1):9-12, 2005
- Sullivan T et al: Tubular carcinoma of the breast: a retrospective analysis and review of the literature. Breast Cancer Res Treat. 93(3):199-205, 2005
- Goldstein NS et al: Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients. Am J Clin Pathol. 122(5):728-39, 2004
- Cabral AH et al: Tubular carcinoma of the breast: an institutional experience and review of the literature. Breast J. 9(4):298-301, 2003
- Holland DW et al: Tubular breast cancer experience at Washington University: a review of the literature. Clin Breast Cancer. 2(3):210-4, 2001
- Kader HA et al: Tubular carcinoma of the breast: a population-based study of nodal metastases at presentation and of patterns of relapse. Breast J. 7(1):8-13, 2001
- Wurdinger S et al: False-negative findings of malignant breast lesions on preoperative magnetic resonance mammography. Breast. 10(2):131-9, 2001
- Sheppard DG et al: Tubular carcinoma of the breast: mammographic and sonographic features. AJR Am J Roentgenol. 174(1):253-7, 2000
- Mitnick JS et al: Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AJR Am J Roentgenol. 172(2):319-23, 1999
- Green I et al: A comparative study of pure tubular and tubulolobular carcinoma of the breast. Am J Surg Pathol. 21:653-7, 1997
- Gupta RK et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 41(4):1139-43, 1997
- McBoyle MF et al: Tubular carcinoma of the breast: an institutional review. Am Surg. 63(7):639-44; discussion 644-5, 1997
