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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
Tubular carcinoma (TC) = cribriform carcinoma: Well-differentiated invasive ductal carcinoma (IDC) composed of tubular structures with single epithelial layer (lacking myoepithelium) and open lumina
Pure TC: Proportion of tubular structures ≥ 90%
IDC with tubular features = IDC with ≥ 50-89% tubular pattern = "mixed" TC
Tubulolobular carcinoma (TLC): Morphologically distinct, rare type of IDC with ≥ 75% of tumor consisting of well-formed tubules and single-file, dyscohesive cells (retaining E-cadherin)
Variable proportions: Predominantly tubular in 27%; equal in 27%; predominantly lobular in 47%
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Chen JX et al: The effects of postoperative radiotherapy on survival outcomes in patients under 65 with estrogen receptor positive tubular breast carcinoma. Radiat Oncol. 13(1):226, 2018
Lee SJ et al: Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer. Medicine (Baltimore). 97(43):e12840, 2018
Poirier É et al: Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast. J Surg Oncol. 117(6):1137-43, 2018
Sun JY et al: Tubular carcinomas of the breast: an epidemiologic study. Future Oncol. ePub, 2018
Wu SG et al: Omission of postoperative radiotherapy in women aged 65 years or older with tubular carcinoma of the breast after breast-conserving surgery. Front Oncol. 8:190, 2018
Zhang WW et al: Clinicopathologic characteristics and clinical outcomes of pure type and mixed type of tubular carcinoma of the breast: a single-institution cohort study. Cancer Manag Res. 10:4509-15, 2018
Boyan W et al: Tubular carcinoma of the breast: a single institution's experience of a favorable prognosis. Am Surg. 82(6):505-9, 2016
Stolnicu S et al: Even small pure tubular carcinoma of the breast (stage T1a and T1b) can be associated with lymph node metastases - The U T MD Anderson Cancer Center experience. Eur J Surg Oncol. 42(6):911-2, 2016
Lea V et al: Tubular carcinoma of the breast: axillary involvement and prognostic factors. ANZ J Surg. 85(6):448-51, 2015
Munzone E et al: Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial. Ann Oncol. 26(12):2442-9, 2015
Romano AM et al: Tubular carcinoma of the breast: institutional and SEER database analysis supporting a unique classification. Breast Dis. 35(2):103-11, 2015
Fritz P et al: Tubular breast cancer. A retrospective study. Anticancer Res. 34(7):3647-56, 2014
Jorns JM et al: Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med. 138(11):1507-13, 2014
Dejode M et al: Pure tubular carcinoma of the breast and sentinel lymph node biopsy: a retrospective multi-institutional study of 234 cases. Eur J Surg Oncol. 39(3):248-54, 2013
Min Y et al: Tubular carcinoma of the breast: clinicopathologic features and survival outcome compared with ductal carcinoma in situ. J Breast Cancer. 16(4):404-9, 2013
Bargalló X et al: Mammographic features of screening detected pT1 (a-b) invasive breast cancer using BI-RADS lexicon. Eur J Radiol. 81(10):2620-6, 2012
Groves AM et al: Defining the role of PET-CT in staging early breast cancer. Oncologist. 17(5):613-9, 2012
Linda A et al: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol. 75(2):178-84, 2010
Manfrin E et al: Cancer size, histotype, and cellular grade may limit the success of fine-needle aspiration cytology for screen-detected breast carcinoma. Cancer. 117(6):491-9, 2009
Esposito NN et al: The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol. 20(1):130-8, 2007
Leikola J et al: The prevalence of axillary lymph-node metastases in patients with pure tubular carcinoma of the breast and sentinel node biopsy. Eur J Surg Oncol. 32(5):488-91, 2006
Marchiò C et al: A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling. Histopathology. 48(5):556-62, 2006
Fernandez-Aguilar S et al: Is complete axillary lymph node dissection neccessary in T1 stage invasive pure tubular carcinomas of the breast? Breast. 14(4):325-8, 2005
Khirwadkar N et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 49(3):344-5, 2005
Leonard CE et al: Excision only for tubular carcinoma of the breast. Breast J. 11(2):129-33, 2005
Livi L et al: Tubular carcinoma of the breast: outcome and loco-regional recurrence in 307 patients. Eur J Surg Oncol. 31(1):9-12, 2005
Sullivan T et al: Tubular carcinoma of the breast: a retrospective analysis and review of the literature. Breast Cancer Res Treat. 93(3):199-205, 2005
Goldstein NS et al: Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients. Am J Clin Pathol. 122(5):728-39, 2004
Cabral AH et al: Tubular carcinoma of the breast: an institutional experience and review of the literature. Breast J. 9(4):298-301, 2003
Holland DW et al: Tubular breast cancer experience at Washington University: a review of the literature. Clin Breast Cancer. 2(3):210-4, 2001
Kader HA et al: Tubular carcinoma of the breast: a population-based study of nodal metastases at presentation and of patterns of relapse. Breast J. 7(1):8-13, 2001
Wurdinger S et al: False-negative findings of malignant breast lesions on preoperative magnetic resonance mammography. Breast. 10(2):131-9, 2001
Sheppard DG et al: Tubular carcinoma of the breast: mammographic and sonographic features. AJR Am J Roentgenol. 174(1):253-7, 2000
Mitnick JS et al: Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AJR Am J Roentgenol. 172(2):319-23, 1999
Green I et al: A comparative study of pure tubular and tubulolobular carcinoma of the breast. Am J Surg Pathol. 21:653-7, 1997
Gupta RK et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 41(4):1139-43, 1997
McBoyle MF et al: Tubular carcinoma of the breast: an institutional review. Am Surg. 63(7):639-44; discussion 644-5, 1997
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
Tubular carcinoma (TC) = cribriform carcinoma: Well-differentiated invasive ductal carcinoma (IDC) composed of tubular structures with single epithelial layer (lacking myoepithelium) and open lumina
Pure TC: Proportion of tubular structures ≥ 90%
IDC with tubular features = IDC with ≥ 50-89% tubular pattern = "mixed" TC
Tubulolobular carcinoma (TLC): Morphologically distinct, rare type of IDC with ≥ 75% of tumor consisting of well-formed tubules and single-file, dyscohesive cells (retaining E-cadherin)
Variable proportions: Predominantly tubular in 27%; equal in 27%; predominantly lobular in 47%
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Chen JX et al: The effects of postoperative radiotherapy on survival outcomes in patients under 65 with estrogen receptor positive tubular breast carcinoma. Radiat Oncol. 13(1):226, 2018
Lee SJ et al: Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer. Medicine (Baltimore). 97(43):e12840, 2018
Poirier É et al: Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast. J Surg Oncol. 117(6):1137-43, 2018
Sun JY et al: Tubular carcinomas of the breast: an epidemiologic study. Future Oncol. ePub, 2018
Wu SG et al: Omission of postoperative radiotherapy in women aged 65 years or older with tubular carcinoma of the breast after breast-conserving surgery. Front Oncol. 8:190, 2018
Zhang WW et al: Clinicopathologic characteristics and clinical outcomes of pure type and mixed type of tubular carcinoma of the breast: a single-institution cohort study. Cancer Manag Res. 10:4509-15, 2018
Boyan W et al: Tubular carcinoma of the breast: a single institution's experience of a favorable prognosis. Am Surg. 82(6):505-9, 2016
Stolnicu S et al: Even small pure tubular carcinoma of the breast (stage T1a and T1b) can be associated with lymph node metastases - The U T MD Anderson Cancer Center experience. Eur J Surg Oncol. 42(6):911-2, 2016
Lea V et al: Tubular carcinoma of the breast: axillary involvement and prognostic factors. ANZ J Surg. 85(6):448-51, 2015
Munzone E et al: Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial. Ann Oncol. 26(12):2442-9, 2015
Romano AM et al: Tubular carcinoma of the breast: institutional and SEER database analysis supporting a unique classification. Breast Dis. 35(2):103-11, 2015
Fritz P et al: Tubular breast cancer. A retrospective study. Anticancer Res. 34(7):3647-56, 2014
Jorns JM et al: Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med. 138(11):1507-13, 2014
Dejode M et al: Pure tubular carcinoma of the breast and sentinel lymph node biopsy: a retrospective multi-institutional study of 234 cases. Eur J Surg Oncol. 39(3):248-54, 2013
Min Y et al: Tubular carcinoma of the breast: clinicopathologic features and survival outcome compared with ductal carcinoma in situ. J Breast Cancer. 16(4):404-9, 2013
Bargalló X et al: Mammographic features of screening detected pT1 (a-b) invasive breast cancer using BI-RADS lexicon. Eur J Radiol. 81(10):2620-6, 2012
Groves AM et al: Defining the role of PET-CT in staging early breast cancer. Oncologist. 17(5):613-9, 2012
Linda A et al: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol. 75(2):178-84, 2010
Manfrin E et al: Cancer size, histotype, and cellular grade may limit the success of fine-needle aspiration cytology for screen-detected breast carcinoma. Cancer. 117(6):491-9, 2009
Esposito NN et al: The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol. 20(1):130-8, 2007
Leikola J et al: The prevalence of axillary lymph-node metastases in patients with pure tubular carcinoma of the breast and sentinel node biopsy. Eur J Surg Oncol. 32(5):488-91, 2006
Marchiò C et al: A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling. Histopathology. 48(5):556-62, 2006
Fernandez-Aguilar S et al: Is complete axillary lymph node dissection neccessary in T1 stage invasive pure tubular carcinomas of the breast? Breast. 14(4):325-8, 2005
Khirwadkar N et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 49(3):344-5, 2005
Leonard CE et al: Excision only for tubular carcinoma of the breast. Breast J. 11(2):129-33, 2005
Livi L et al: Tubular carcinoma of the breast: outcome and loco-regional recurrence in 307 patients. Eur J Surg Oncol. 31(1):9-12, 2005
Sullivan T et al: Tubular carcinoma of the breast: a retrospective analysis and review of the literature. Breast Cancer Res Treat. 93(3):199-205, 2005
Goldstein NS et al: Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients. Am J Clin Pathol. 122(5):728-39, 2004
Cabral AH et al: Tubular carcinoma of the breast: an institutional experience and review of the literature. Breast J. 9(4):298-301, 2003
Holland DW et al: Tubular breast cancer experience at Washington University: a review of the literature. Clin Breast Cancer. 2(3):210-4, 2001
Kader HA et al: Tubular carcinoma of the breast: a population-based study of nodal metastases at presentation and of patterns of relapse. Breast J. 7(1):8-13, 2001
Wurdinger S et al: False-negative findings of malignant breast lesions on preoperative magnetic resonance mammography. Breast. 10(2):131-9, 2001
Sheppard DG et al: Tubular carcinoma of the breast: mammographic and sonographic features. AJR Am J Roentgenol. 174(1):253-7, 2000
Mitnick JS et al: Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AJR Am J Roentgenol. 172(2):319-23, 1999
Green I et al: A comparative study of pure tubular and tubulolobular carcinoma of the breast. Am J Surg Pathol. 21:653-7, 1997
Gupta RK et al: Fine needle aspiration cytology of tubular carcinoma of the breast. Acta Cytol. 41(4):1139-43, 1997
McBoyle MF et al: Tubular carcinoma of the breast: an institutional review. Am Surg. 63(7):639-44; discussion 644-5, 1997
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