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Tumoral Calcinosis, Cervical Spine
Jeffrey S. Ross, MD; Lubdha M. Shah, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Extraskeletal tumoral calcification, calcifying pseudoneoplasm, lipocalcinogranulomatosis
              • Definitions

                • Benign periarticular soft tissue hyperplasia with calcification

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Ashraf A et al: Infantile tumoral calcinosis of the cervical spine presenting as torticollis. Clin Imaging. 40(1):161-3, 2016
                                      2. Fatehi M et al: Uremic tumoral calcinosis in the cervical spine: case report. J Neurosurg Spine. 1-5, 2016
                                      3. Al-Khudairi N et al: A case of symptomatic cervical spine calcinosis in systemic sclerosis. Spine J. 15(9):2099-100, 2015
                                      4. Sambataro D et al: Tumoral calcinosis of the spine in the course of systemic sclerosis: report of a new case and review of the literature. Clin Exp Rheumatol. 33(4 Suppl 91):S175-8, 2015
                                      5. Sasaki O et al: Tumoral calcinosis involving the cervical spine. Surg Neurol Int. 6:109, 2015
                                      6. Issa El Khoury F et al: Tumoral calcinosis of the cervical spine and its association with Caffey disease in a 4-month-old boy: case report and review of the literature. J Pediatr Orthop B. 21(3):286-91, 2012
                                      7. Krejci P et al: Molecular pathology of the fibroblast growth factor family. Hum Mutat. 30(9):1245-55, 2009
                                      8. McKenzie G et al: Pictorial review: Non-neoplastic soft-tissue masses. Br J Radiol. 82(981):775-85, 2009
                                      9. Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
                                      10. Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
                                      11. Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-39, 2002
                                      12. Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
                                      13. Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
                                      14. Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
                                      15. Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
                                      16. Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
                                      17. Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
                                      18. Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
                                      19. Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
                                      20. Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
                                      21. McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
                                      22. McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
                                      23. Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
                                      24. Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
                                      25. Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-250S, 1995
                                      26. Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
                                      27. Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
                                      28. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                                      29. Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
                                      30. Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
                                      31. Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Extraskeletal tumoral calcification, calcifying pseudoneoplasm, lipocalcinogranulomatosis
                                                  • Definitions

                                                    • Benign periarticular soft tissue hyperplasia with calcification

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Ashraf A et al: Infantile tumoral calcinosis of the cervical spine presenting as torticollis. Clin Imaging. 40(1):161-3, 2016
                                                                          2. Fatehi M et al: Uremic tumoral calcinosis in the cervical spine: case report. J Neurosurg Spine. 1-5, 2016
                                                                          3. Al-Khudairi N et al: A case of symptomatic cervical spine calcinosis in systemic sclerosis. Spine J. 15(9):2099-100, 2015
                                                                          4. Sambataro D et al: Tumoral calcinosis of the spine in the course of systemic sclerosis: report of a new case and review of the literature. Clin Exp Rheumatol. 33(4 Suppl 91):S175-8, 2015
                                                                          5. Sasaki O et al: Tumoral calcinosis involving the cervical spine. Surg Neurol Int. 6:109, 2015
                                                                          6. Issa El Khoury F et al: Tumoral calcinosis of the cervical spine and its association with Caffey disease in a 4-month-old boy: case report and review of the literature. J Pediatr Orthop B. 21(3):286-91, 2012
                                                                          7. Krejci P et al: Molecular pathology of the fibroblast growth factor family. Hum Mutat. 30(9):1245-55, 2009
                                                                          8. McKenzie G et al: Pictorial review: Non-neoplastic soft-tissue masses. Br J Radiol. 82(981):775-85, 2009
                                                                          9. Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
                                                                          10. Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
                                                                          11. Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-39, 2002
                                                                          12. Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
                                                                          13. Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
                                                                          14. Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
                                                                          15. Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
                                                                          16. Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
                                                                          17. Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
                                                                          18. Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
                                                                          19. Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
                                                                          20. Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
                                                                          21. McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
                                                                          22. McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
                                                                          23. Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
                                                                          24. Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
                                                                          25. Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-250S, 1995
                                                                          26. Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
                                                                          27. Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
                                                                          28. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                                                                          29. Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
                                                                          30. Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
                                                                          31. Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992