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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Tumoral calcinosis (TC)
- Familial tumoral calcinosis (FTC)
Synonyms
- Extraskeletal tumoral calcification, calcifying pseudoneoplasm
- Lipocalcinogranulomatosis
- Calcifying collagenolysis
- Tumor lipocalcinosis
Definitions
- Periarticular soft tissue hyperplasia, calcification
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Ebot J et al: Tumoral calcinosis of the lumbar and cervical spine. J Clin Neurosci. 62:243-5, 2019
- Al-Sukaini A et al: Idiopathic tumoral calcinosis-like lesion in the lower cervical spine causing acute central cord syndrome: case report. J Neurosurg Spine. 26(1):97-102, 2017
- Sasaki O et al: Tumoral calcinosis involving the cervical spine. Surg Neurol Int. 6:109, 2015
- Fathi I et al: Review of tumoral calcinosis: a rare clinico-pathological entity. World J Clin Cases. 2(9):409-14, 2014
- Rafaelsen S et al: Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 15(1):98, 2014
- Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
- Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
- Benet-Pagès A et al: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 14(3):385-90, 2005
- Topaz O et al: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 36(6):579-81, 2004
- Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-9, 2002
- Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
- Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
- Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
- Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
- Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
- Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
- Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
- Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
- Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
- McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
- McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
- Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
- Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
- Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-50S, 1995
- Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
- Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
- Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
- Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
- Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
- Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Tumoral calcinosis (TC)
- Familial tumoral calcinosis (FTC)
Synonyms
- Extraskeletal tumoral calcification, calcifying pseudoneoplasm
- Lipocalcinogranulomatosis
- Calcifying collagenolysis
- Tumor lipocalcinosis
Definitions
- Periarticular soft tissue hyperplasia, calcification
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Ebot J et al: Tumoral calcinosis of the lumbar and cervical spine. J Clin Neurosci. 62:243-5, 2019
- Al-Sukaini A et al: Idiopathic tumoral calcinosis-like lesion in the lower cervical spine causing acute central cord syndrome: case report. J Neurosurg Spine. 26(1):97-102, 2017
- Sasaki O et al: Tumoral calcinosis involving the cervical spine. Surg Neurol Int. 6:109, 2015
- Fathi I et al: Review of tumoral calcinosis: a rare clinico-pathological entity. World J Clin Cases. 2(9):409-14, 2014
- Rafaelsen S et al: Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 15(1):98, 2014
- Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
- Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
- Benet-Pagès A et al: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 14(3):385-90, 2005
- Topaz O et al: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 36(6):579-81, 2004
- Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-9, 2002
- Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
- Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
- Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
- Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
- Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
- Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
- Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
- Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
- Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
- McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
- McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
- Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
- Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
- Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-50S, 1995
- Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
- Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
- Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
- Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
- Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
- Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992
