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Tumoral Calcinosis
Kevin R. Moore, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Tumoral calcinosis (TC)
              • Familial tumoral calcinosis (FTC)
            • Synonyms

              • Extraskeletal tumoral calcification, calcifying pseudoneoplasm
              • Lipocalcinogranulomatosis
              • Calcifying collagenolysis
              • Tumor lipocalcinosis
            • Definitions

              • Periarticular soft tissue hyperplasia, calcification

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Ebot J et al: Tumoral calcinosis of the lumbar and cervical spine. J Clin Neurosci. 62:243-5, 2019
                                            2. Al-Sukaini A et al: Idiopathic tumoral calcinosis-like lesion in the lower cervical spine causing acute central cord syndrome: case report. J Neurosurg Spine. 26(1):97-102, 2017
                                            3. Sasaki O et al: Tumoral calcinosis involving the cervical spine. Surg Neurol Int. 6:109, 2015
                                            4. Fathi I et al: Review of tumoral calcinosis: a rare clinico-pathological entity. World J Clin Cases. 2(9):409-14, 2014
                                            5. Rafaelsen S et al: Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 15(1):98, 2014
                                            6. Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
                                            7. Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
                                            8. Benet-Pagès A et al: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 14(3):385-90, 2005
                                            9. Topaz O et al: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 36(6):579-81, 2004
                                            10. Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-9, 2002
                                            11. Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
                                            12. Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
                                            13. Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
                                            14. Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
                                            15. Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
                                            16. Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
                                            17. Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
                                            18. Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
                                            19. Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
                                            20. McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
                                            21. McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
                                            22. Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
                                            23. Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
                                            24. Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-50S, 1995
                                            25. Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
                                            26. Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
                                            27. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                                            28. Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
                                            29. Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
                                            30. Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Tumoral calcinosis (TC)
                                                        • Familial tumoral calcinosis (FTC)
                                                      • Synonyms

                                                        • Extraskeletal tumoral calcification, calcifying pseudoneoplasm
                                                        • Lipocalcinogranulomatosis
                                                        • Calcifying collagenolysis
                                                        • Tumor lipocalcinosis
                                                      • Definitions

                                                        • Periarticular soft tissue hyperplasia, calcification

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Ebot J et al: Tumoral calcinosis of the lumbar and cervical spine. J Clin Neurosci. 62:243-5, 2019
                                                                                      2. Al-Sukaini A et al: Idiopathic tumoral calcinosis-like lesion in the lower cervical spine causing acute central cord syndrome: case report. J Neurosurg Spine. 26(1):97-102, 2017
                                                                                      3. Sasaki O et al: Tumoral calcinosis involving the cervical spine. Surg Neurol Int. 6:109, 2015
                                                                                      4. Fathi I et al: Review of tumoral calcinosis: a rare clinico-pathological entity. World J Clin Cases. 2(9):409-14, 2014
                                                                                      5. Rafaelsen S et al: Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 15(1):98, 2014
                                                                                      6. Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
                                                                                      7. Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
                                                                                      8. Benet-Pagès A et al: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 14(3):385-90, 2005
                                                                                      9. Topaz O et al: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 36(6):579-81, 2004
                                                                                      10. Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-9, 2002
                                                                                      11. Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
                                                                                      12. Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
                                                                                      13. Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
                                                                                      14. Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
                                                                                      15. Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
                                                                                      16. Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
                                                                                      17. Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
                                                                                      18. Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
                                                                                      19. Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
                                                                                      20. McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
                                                                                      21. McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
                                                                                      22. Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
                                                                                      23. Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
                                                                                      24. Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-50S, 1995
                                                                                      25. Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
                                                                                      26. Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
                                                                                      27. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                                                                                      28. Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
                                                                                      29. Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
                                                                                      30. Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992