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Tumoral Calcinosis
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Abbreviations

            • Tumoral calcinosis (TC)
            • Familial tumoral calcinosis (FTC)
          • Synonyms

            • Extraskeletal tumoral calcification, calcifying pseudoneoplasm
            • Lipocalcinogranulomatosis
            • Calcifying collagenolysis
            • Tumor lipocalcinosis
          • Definitions

            • Periarticular soft tissue hyperplasia, calcification

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Fathi I et al: Review of tumoral calcinosis: A rare clinico-pathological entity. World J Clin Cases. 2(9):409-14, 2014
                                          2. Rafaelsen S et al: Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 15(1):98, 2014
                                          3. Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
                                          4. Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
                                          5. Benet-Pagès A et al: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 14(3):385-90, 2005
                                          6. Topaz O et al: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 36(6):579-81, 2004
                                          7. Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-39, 2002
                                          8. Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
                                          9. Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
                                          10. Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
                                          11. Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
                                          12. Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
                                          13. Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
                                          14. Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
                                          15. Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
                                          16. Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
                                          17. McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
                                          18. McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
                                          19. Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
                                          20. Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
                                          21. Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-250S, 1995
                                          22. Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
                                          23. Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
                                          24. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                                          25. Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
                                          26. Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
                                          27. Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Tumoral calcinosis (TC)
                                                    • Familial tumoral calcinosis (FTC)
                                                  • Synonyms

                                                    • Extraskeletal tumoral calcification, calcifying pseudoneoplasm
                                                    • Lipocalcinogranulomatosis
                                                    • Calcifying collagenolysis
                                                    • Tumor lipocalcinosis
                                                  • Definitions

                                                    • Periarticular soft tissue hyperplasia, calcification

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Fathi I et al: Review of tumoral calcinosis: A rare clinico-pathological entity. World J Clin Cases. 2(9):409-14, 2014
                                                                                  2. Rafaelsen S et al: Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 15(1):98, 2014
                                                                                  3. Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient.] Ann Dermatol Venereol. 136(4):350-4, 2009
                                                                                  4. Jackson W et al: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976). 32(19):E557-60, 2007
                                                                                  5. Benet-Pagès A et al: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 14(3):385-90, 2005
                                                                                  6. Topaz O et al: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 36(6):579-81, 2004
                                                                                  7. Martinez S: Tumoral calcinosis: 12 years later. Semin Musculoskelet Radiol. 6(4): 331-39, 2002
                                                                                  8. Blay P et al: Vertebral involvement in hyperphosphatemic tumoral calcinosis. Bone. 28(3): 316-8, 2001
                                                                                  9. Durant DM et al: Tumoral calcinosis of the spine: a study of 21 cases. Spine. 26(15): 1673-9, 2001
                                                                                  10. Matsukado K et al: Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy--case report. Neurol Med Chir (Tokyo). 41(8): 411-4, 2001
                                                                                  11. Watanabe A et al: Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 47(1): 230-2, 2000
                                                                                  12. Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. Neuroradiology. 41(5):351-5, 1999
                                                                                  13. Reginato AJ et al: Familial and clinical aspects of calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 1(2): 112-20, 1999
                                                                                  14. Kokubun S et al: Tumoral calcinosis in the upper cervical spine: a case report. Spine. 21(2): 249-52, 1996
                                                                                  15. Ohashi K et al: Idiopathic tumoral calcinosis involving the cervical spine. Skeletal Radiol. 25(4): 388-90, 1996
                                                                                  16. Geirnaerdt MJ et al: Tumoral calcinosis. Skeletal Radiol. 24(2):148-51, 1995
                                                                                  17. McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. Hum Pathol. 26(6):607-13, 1995
                                                                                  18. McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. Clin Radiol. 50(4):259-64, 1995
                                                                                  19. Shaffrey CI et al: Tumoral calcium pyrophosphate dihydrate deposition disease mimicking a cervical spine neoplasm: case report. Neurosurgery. 37(2): 335-9, 1995
                                                                                  20. Steinbach LS et al: Tumoral calcinosis: radiologic-pathologic correlation. Skeletal Radiol. 24(8):573-8, 1995
                                                                                  21. Yamaguchi T et al: Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide. Bone. 16(4 Suppl):247S-250S, 1995
                                                                                  22. Calloway DM et al: Combined modality treatment for tumoral calcinosis. Orthop Rev. 22(3):365-9, 1993
                                                                                  23. Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. Acta Orthop Belg. 59(3):249-54, 1993
                                                                                  24. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                                                                                  25. Slavin RE et al: Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am J Surg Pathol. 17(8):788-802, 1993
                                                                                  26. Tezelman S et al: Tumoral calcinosis. Controversies in the etiology and alternatives in the treatment. Arch Surg. 128(7):737-44; discussion 744-5, 1993
                                                                                  27. Fam AG: Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases. Curr Opin Rheumatol. 4(4):574-82, 1992