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Ultrasound Contrast Agents: Definity
John Eisenbrey, PhD; Luna Hilaire, PhD; Ginger Warner
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KEY FACTS

  • Terminology

    • Clinical Implications

      • Imaging Recommendations

        TERMINOLOGY

        • Definitions

          • Definity (as marketed in North America) or Luminity (as marketed in Europe)
            • US contrast agent produced by Lantheus Medical Imaging, Inc., North Billerica, MA

        CLINICAL IMPLICATIONS

        • Contrast Agent

          • Pharmacokinetics

            • Storage and Handling

              Dosage and Administration

              • Preparation Instructions

                • Injection Instructions

                  • Manufacturer-Recommended Dosages

                    • Dosage Variations

                      • Technical Pitfalls and Challenges

                        CONTRAINDICATIONS

                        • Use of Definity

                          PRECAUTIONS

                          • Adverse Reactions

                            • Cardiopulmonary Reactions

                              • Hypersensitivity Reactions

                                • Systemic Embolization

                                  USE IN SPECIFIC POPULATIONS

                                  • Pregnancy

                                    • Lactation

                                      Selected References

                                      1. Parker JM et al: Safety of ultrasound contrast agents in patients with known or suspected cardiac shunts. Am J Cardiol. 112(7):1039-45, 2013
                                      2. Abdelmoneim SS et al: Safety of contrast agent use during stress echocardiography in patients with elevated right ventricular systolic pressure: a cohort study. Circ Cardiovasc Imaging. 3(3):240-8, 2010
                                      3. Wilson SR et al: Diagnosis of focal liver masses on ultrasonography: comparison of unenhanced and contrast-enhanced scans. J Ultrasound Med. 26(6):775-87; quiz 788-90, 2007
                                      4. Kitzman DW et al: Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic images. Am J Cardiol. 86(6):669-74, 2000
                                      5. Definity Product Insert (USA). http://www.definityimaging.com/pdf/Definity%20US%20PI%20515987-1017.pdf. Accessed November 2018.
                                      6. Luminity Product Insert. https://www.ema.europa.eu/documents/product-information/luminity-epar-product-information_en.pdf. Accessed November 2018.
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Clinical Implications

                                          • Imaging Recommendations

                                            TERMINOLOGY

                                            • Definitions

                                              • Definity (as marketed in North America) or Luminity (as marketed in Europe)
                                                • US contrast agent produced by Lantheus Medical Imaging, Inc., North Billerica, MA

                                            CLINICAL IMPLICATIONS

                                            • Contrast Agent

                                              • Pharmacokinetics

                                                • Storage and Handling

                                                  Dosage and Administration

                                                  • Preparation Instructions

                                                    • Injection Instructions

                                                      • Manufacturer-Recommended Dosages

                                                        • Dosage Variations

                                                          • Technical Pitfalls and Challenges

                                                            CONTRAINDICATIONS

                                                            • Use of Definity

                                                              PRECAUTIONS

                                                              • Adverse Reactions

                                                                • Cardiopulmonary Reactions

                                                                  • Hypersensitivity Reactions

                                                                    • Systemic Embolization

                                                                      USE IN SPECIFIC POPULATIONS

                                                                      • Pregnancy

                                                                        • Lactation

                                                                          Selected References

                                                                          1. Parker JM et al: Safety of ultrasound contrast agents in patients with known or suspected cardiac shunts. Am J Cardiol. 112(7):1039-45, 2013
                                                                          2. Abdelmoneim SS et al: Safety of contrast agent use during stress echocardiography in patients with elevated right ventricular systolic pressure: a cohort study. Circ Cardiovasc Imaging. 3(3):240-8, 2010
                                                                          3. Wilson SR et al: Diagnosis of focal liver masses on ultrasonography: comparison of unenhanced and contrast-enhanced scans. J Ultrasound Med. 26(6):775-87; quiz 788-90, 2007
                                                                          4. Kitzman DW et al: Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic images. Am J Cardiol. 86(6):669-74, 2000
                                                                          5. Definity Product Insert (USA). http://www.definityimaging.com/pdf/Definity%20US%20PI%20515987-1017.pdf. Accessed November 2018.
                                                                          6. Luminity Product Insert. https://www.ema.europa.eu/documents/product-information/luminity-epar-product-information_en.pdf. Accessed November 2018.