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Ultrasound Contrast Agents: Optison
John Eisenbrey, PhD
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KEY FACTS

  • Terminology

    • Clinical Implications

      • Imaging Recommendations

        TERMINOLOGY

        • Definitions

          • Optison
            • US contrast agent manufactured by GE Healthcare AS, Oslo, Norway

        CLINICAL IMPLICATIONS

        • Contrast Agent

          • Pharmacokinetics

            • Storage and Handling

              Dosage and Administration

              • Preparation Instructions

                • Injection Instructions

                  • Manufacturer-Recommended Dosages

                    • Dosage Variations

                      • Technical Pitfalls and Challenges

                        CONTRAINDICATIONS

                        • Use of Optison

                          PRECAUTIONS

                          • Adverse Reactions

                            • Serious Cardiopulmonary Reactions

                              • Hypersensitivity Reactions

                                • Systemic Embolization

                                  • Ventricular Arrhythmia Related to High Mechanical Index

                                    • Transmissible Infectious Agents

                                      USE IN SPECIFIC POPULATIONS

                                      • Pregnancy

                                        • Lactation

                                          Selected References

                                          1. Back SJ et al: Pediatric contrast-enhanced ultrasound in the United States: a survey by the Contrast-Enhanced Ultrasound Task Force of the Society for Pediatric Radiology. Pediatr Radiol. 48(6):852-857, 2018
                                          2. Eisenbrey JR et al: Contrast-enhanced subharmonic and harmonic ultrasound of renal masses undergoing percutaneous cryoablation. Acad Radiol. 22(7):820-6, 2015
                                          3. Wei K et al: The safety of deFinity and Optison for ultrasound image enhancement: a retrospective analysis of 78,383 administered contrast doses. J Am Soc Echocardiogr. 21(11):1202-6, 2008
                                          4. Strobel D et al: Phase inversion harmonic imaging versus contrast-enhanced power Doppler sonography for the characterization of focal liver lesions. Int J Colorectal Dis. 18(1):63-72, 2003
                                          5. Shi WT et al: Ultrasonic characterization of the nonlinear properties of contrast microbubbles. Ultrasound Med Biol. 26(1):93-104, 2000
                                          6. Brown JM et al: Contrast-enhanced ultrasound for guidance of local tumor ablation. Ultrasound Med Biol. 25(8):1213-9, 1999
                                          7. Barnhart J et al: Characteristics of Albunex: air-filled albumin microspheres for echocardiography contrast enhancement. Invest Radiol. 25 Suppl 1:S162-4, 1990
                                          8. Feinstein SB et al: Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. J Am Coll Cardiol. 16(2):316-24, 1990
                                          9. Keller MW et al: Albunex: a safe and effective commercially produced agent for myocardial contrast echocardiography. J Am Soc Echocardiogr. 2(1):48-52, 1989
                                          10. Optison Product Insert. http://www3.gehealthcare.com/~/media/documents/MarketoPDFsnogating/OPT-1H-OSLO_Optison_BK. Accessed November 2018.
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Clinical Implications

                                              • Imaging Recommendations

                                                TERMINOLOGY

                                                • Definitions

                                                  • Optison
                                                    • US contrast agent manufactured by GE Healthcare AS, Oslo, Norway

                                                CLINICAL IMPLICATIONS

                                                • Contrast Agent

                                                  • Pharmacokinetics

                                                    • Storage and Handling

                                                      Dosage and Administration

                                                      • Preparation Instructions

                                                        • Injection Instructions

                                                          • Manufacturer-Recommended Dosages

                                                            • Dosage Variations

                                                              • Technical Pitfalls and Challenges

                                                                CONTRAINDICATIONS

                                                                • Use of Optison

                                                                  PRECAUTIONS

                                                                  • Adverse Reactions

                                                                    • Serious Cardiopulmonary Reactions

                                                                      • Hypersensitivity Reactions

                                                                        • Systemic Embolization

                                                                          • Ventricular Arrhythmia Related to High Mechanical Index

                                                                            • Transmissible Infectious Agents

                                                                              USE IN SPECIFIC POPULATIONS

                                                                              • Pregnancy

                                                                                • Lactation

                                                                                  Selected References

                                                                                  1. Back SJ et al: Pediatric contrast-enhanced ultrasound in the United States: a survey by the Contrast-Enhanced Ultrasound Task Force of the Society for Pediatric Radiology. Pediatr Radiol. 48(6):852-857, 2018
                                                                                  2. Eisenbrey JR et al: Contrast-enhanced subharmonic and harmonic ultrasound of renal masses undergoing percutaneous cryoablation. Acad Radiol. 22(7):820-6, 2015
                                                                                  3. Wei K et al: The safety of deFinity and Optison for ultrasound image enhancement: a retrospective analysis of 78,383 administered contrast doses. J Am Soc Echocardiogr. 21(11):1202-6, 2008
                                                                                  4. Strobel D et al: Phase inversion harmonic imaging versus contrast-enhanced power Doppler sonography for the characterization of focal liver lesions. Int J Colorectal Dis. 18(1):63-72, 2003
                                                                                  5. Shi WT et al: Ultrasonic characterization of the nonlinear properties of contrast microbubbles. Ultrasound Med Biol. 26(1):93-104, 2000
                                                                                  6. Brown JM et al: Contrast-enhanced ultrasound for guidance of local tumor ablation. Ultrasound Med Biol. 25(8):1213-9, 1999
                                                                                  7. Barnhart J et al: Characteristics of Albunex: air-filled albumin microspheres for echocardiography contrast enhancement. Invest Radiol. 25 Suppl 1:S162-4, 1990
                                                                                  8. Feinstein SB et al: Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. J Am Coll Cardiol. 16(2):316-24, 1990
                                                                                  9. Keller MW et al: Albunex: a safe and effective commercially produced agent for myocardial contrast echocardiography. J Am Soc Echocardiogr. 2(1):48-52, 1989
                                                                                  10. Optison Product Insert. http://www3.gehealthcare.com/~/media/documents/MarketoPDFsnogating/OPT-1H-OSLO_Optison_BK. Accessed November 2018.