Not recommended: malignant fibrous histiocytoma of bone, pleomorphic fibrosarcoma of bone
Definitions
Pleomorphic malignant neoplasm of bone with no identifiable line of differentiation
Diagnosis of exclusion
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Berkeley R et al: The rare primary bone sarcomas: imaging-pathological correlation. Skeletal Radiol. 50(8):1491-511, 2021
Inwards CY et al: Undifferentiated pleomorphic sarcoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 480-2, 2020
Malik AT et al: Malignant fibrous histiocytoma of bone: a survival analysis from the National Cancer Database. J Surg Oncol. 121(7):1097-103, 2020
Qu N et al: Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore). 94(3):e369, 2015
Koplas MC et al: Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. Skeletal Radiol. 39(8):791-8, 2010
Domson GF et al: Infarct-associated bone sarcomas. Clin Orthop Relat Res. 467(7):1820-5, 2009
Min WK et al: Malignant fibrous histiocytoma arising in the area of total hip replacement. Joint Bone Spine. 75(3):319-21, 2008
Richter H et al: Malignant fibrous histiocytoma associated with remote internal fixation of an ankle fracture. Foot Ankle Int. 27(5):375-9, 2006
Tarkkanen M et al: Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. Eur J Cancer. 42(8):1172-80, 2006
Zlowodzki M et al: Case reports: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. Clin Orthop Relat Res. 439:269-73, 2005
Murphey MD et al: From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. Radiographics. 14(4):807-26; quiz 827-8, 1994
Yokoyama R et al: Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. Cancer. 72(6):1902-8, 1993
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Undifferentiated pleomorphic sarcoma (UPS)
Synonyms
Not recommended: malignant fibrous histiocytoma of bone, pleomorphic fibrosarcoma of bone
Definitions
Pleomorphic malignant neoplasm of bone with no identifiable line of differentiation
Diagnosis of exclusion
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Berkeley R et al: The rare primary bone sarcomas: imaging-pathological correlation. Skeletal Radiol. 50(8):1491-511, 2021
Inwards CY et al: Undifferentiated pleomorphic sarcoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 480-2, 2020
Malik AT et al: Malignant fibrous histiocytoma of bone: a survival analysis from the National Cancer Database. J Surg Oncol. 121(7):1097-103, 2020
Qu N et al: Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore). 94(3):e369, 2015
Koplas MC et al: Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. Skeletal Radiol. 39(8):791-8, 2010
Domson GF et al: Infarct-associated bone sarcomas. Clin Orthop Relat Res. 467(7):1820-5, 2009
Min WK et al: Malignant fibrous histiocytoma arising in the area of total hip replacement. Joint Bone Spine. 75(3):319-21, 2008
Richter H et al: Malignant fibrous histiocytoma associated with remote internal fixation of an ankle fracture. Foot Ankle Int. 27(5):375-9, 2006
Tarkkanen M et al: Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. Eur J Cancer. 42(8):1172-80, 2006
Zlowodzki M et al: Case reports: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. Clin Orthop Relat Res. 439:269-73, 2005
Murphey MD et al: From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. Radiographics. 14(4):807-26; quiz 827-8, 1994
Yokoyama R et al: Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. Cancer. 72(6):1902-8, 1993
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