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Head and Neck
Diagnosis
Hypopharynx, Larynx, and Cervical Trachea
Benign and Malignant Tumors
Upper Airway Infantile Hemangioma
Upper Airway Infantile Hemangioma
Bernadette L. Koch, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Infantile hemangioma, subglottic hemangioma

            • Definitions

              • Hemangioma involving subglottic airway

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. ISSVA Classification of Vascular Anomalies ©2018 International Society for the Study of Vascular Anomalies. Accessed November 22, 2020. http://issva.org/classification
                                        2. McCormick AA et al: Subglottic hemangioma: understanding the association with facial segmental hemangioma in a beard distribution. Int J Pediatr Otorhinolaryngol. 113:34-7, 2018
                                        3. Schwartz T et al: Efficacy and rebound rates in propranolol-treated subglottic hemangioma: a literature review. Laryngoscope. 127(11):2665-72, 2017
                                        4. Mamlouk MD et al: Arterial spin-labeled perfusion for vascular anomalies in the pediatric head and neck. Clin Imaging. 40(5):1040-6, 2016
                                        5. Merrow AC et al: 2014 Revised classification of vascular lesions from the international society for the study of vascular anomalies: radiologic-pathologic update. Radiographics. 36(5):1494-516, 2016
                                        6. Vivas-Colmenares GV et al: Analysis of the therapeutic evolution in the management of airway infantile hemangioma. World J Clin Pediatr. 5(1):95-101, 2016
                                        7. Wang CF et al: Treatment of infantile subglottic hemangioma with oral propranolol. Pediatr Int. 58(5):385-8, 2016
                                        8. Siegel B et al: Open airway surgery for subglottic hemangioma in the era of propranolol: Is it still indicated? Int J Pediatr Otorhinolaryngol. 79(7):1124-7, 2015
                                        9. Badi AN et al: Histopathologic and immunophenotypic profile of subglottic hemangioma: multicenter study. Int J Pediatr Otorhinolaryngol. 73(9):1187-91, 2009
                                        10. Denoyelle F et al: Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol. 73(8):1168-72, 2009
                                        11. Perkins JA et al: Emerging concepts in airway infantile hemangioma assessment and management. Otolaryngol Head Neck Surg. 141(2):207-212, 2009
                                        12. Liang MG et al: Glucose transporter-1 protein is immunohistochemically expressed in subglottic infantile haemangioma. Br J Dermatol. 158(4):862-3, 2008
                                        13. O-Lee TJ et al: Subglottic hemangioma. Otolaryngol Clin North Am. 41(5):903-11, viii-ix, 2008
                                        14. Saetti R et al: Treatment of congenital subglottic hemangiomas: our experience compared with reports in the literature. Arch Otolaryngol Head Neck Surg. 134(8):848-51, 2008
                                        15. Kubba H et al: Subglottic haemangioma in children: experience with open surgical excision. J Laryngol Otol. 121(12):1215; author reply 1215-6, 2007
                                        16. Pransky SM et al: Management of subglottic hemangioma. Curr Opin Otolaryngol Head Neck Surg. 12(6):509-512, 2004
                                        17. Rahbar R et al: The biology and management of subglottic hemangioma: past, present, future. Laryngoscope. 114(11):1880-91, 2004
                                        18. Re M et al: Role of endoscopic CO2 laser surgery in the treatment of congenital infantile subglottic hemangioma. Experience in the Department of Otolaryngology, "Sick Children Hospital", Toronto, Canada. Acta Otorhinolaryngol Ital. 23(3):175-9, 2003
                                        19. Poetke M et al: PHACE syndrome: new views on diagnostic criteria. Eur J Pediatr Surg. 12(6):366-74, 2002
                                        20. Mulliken JB et al: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69(3):412-22, 1982
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Infantile hemangioma, subglottic hemangioma

                                                  • Definitions

                                                    • Hemangioma involving subglottic airway

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. ISSVA Classification of Vascular Anomalies ©2018 International Society for the Study of Vascular Anomalies. Accessed November 22, 2020. http://issva.org/classification
                                                                              2. McCormick AA et al: Subglottic hemangioma: understanding the association with facial segmental hemangioma in a beard distribution. Int J Pediatr Otorhinolaryngol. 113:34-7, 2018
                                                                              3. Schwartz T et al: Efficacy and rebound rates in propranolol-treated subglottic hemangioma: a literature review. Laryngoscope. 127(11):2665-72, 2017
                                                                              4. Mamlouk MD et al: Arterial spin-labeled perfusion for vascular anomalies in the pediatric head and neck. Clin Imaging. 40(5):1040-6, 2016
                                                                              5. Merrow AC et al: 2014 Revised classification of vascular lesions from the international society for the study of vascular anomalies: radiologic-pathologic update. Radiographics. 36(5):1494-516, 2016
                                                                              6. Vivas-Colmenares GV et al: Analysis of the therapeutic evolution in the management of airway infantile hemangioma. World J Clin Pediatr. 5(1):95-101, 2016
                                                                              7. Wang CF et al: Treatment of infantile subglottic hemangioma with oral propranolol. Pediatr Int. 58(5):385-8, 2016
                                                                              8. Siegel B et al: Open airway surgery for subglottic hemangioma in the era of propranolol: Is it still indicated? Int J Pediatr Otorhinolaryngol. 79(7):1124-7, 2015
                                                                              9. Badi AN et al: Histopathologic and immunophenotypic profile of subglottic hemangioma: multicenter study. Int J Pediatr Otorhinolaryngol. 73(9):1187-91, 2009
                                                                              10. Denoyelle F et al: Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol. 73(8):1168-72, 2009
                                                                              11. Perkins JA et al: Emerging concepts in airway infantile hemangioma assessment and management. Otolaryngol Head Neck Surg. 141(2):207-212, 2009
                                                                              12. Liang MG et al: Glucose transporter-1 protein is immunohistochemically expressed in subglottic infantile haemangioma. Br J Dermatol. 158(4):862-3, 2008
                                                                              13. O-Lee TJ et al: Subglottic hemangioma. Otolaryngol Clin North Am. 41(5):903-11, viii-ix, 2008
                                                                              14. Saetti R et al: Treatment of congenital subglottic hemangiomas: our experience compared with reports in the literature. Arch Otolaryngol Head Neck Surg. 134(8):848-51, 2008
                                                                              15. Kubba H et al: Subglottic haemangioma in children: experience with open surgical excision. J Laryngol Otol. 121(12):1215; author reply 1215-6, 2007
                                                                              16. Pransky SM et al: Management of subglottic hemangioma. Curr Opin Otolaryngol Head Neck Surg. 12(6):509-512, 2004
                                                                              17. Rahbar R et al: The biology and management of subglottic hemangioma: past, present, future. Laryngoscope. 114(11):1880-91, 2004
                                                                              18. Re M et al: Role of endoscopic CO2 laser surgery in the treatment of congenital infantile subglottic hemangioma. Experience in the Department of Otolaryngology, "Sick Children Hospital", Toronto, Canada. Acta Otorhinolaryngol Ital. 23(3):175-9, 2003
                                                                              19. Poetke M et al: PHACE syndrome: new views on diagnostic criteria. Eur J Pediatr Surg. 12(6):366-74, 2002
                                                                              20. Mulliken JB et al: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69(3):412-22, 1982