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Ureteropelvic Junction Obstruction
Sara M. O'Hara, MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Pelviureteric obstruction
          • Definitions

            • Ureteropelvic junction (UPJ) obstruction: Variable degree of blockage to urine flow at level of UPJ
            • Most common urinary tract obstruction in pediatrics
            • May be diagnosed antenatally with sonography or present in infancy or later childhood with urinary tract infection, intermittent abdominal pain, vomiting, &/or hematuria
              • Occasionally found incidentally during trauma work-up

          IMAGING

          • General Features

            • Radiographic Findings

              • Ultrasonographic Findings

                • Fluoroscopic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Other Modality Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              Selected References

                                              1. Houat AP et al: Congenital anomalies of the upper urinary tract: a comprehensive review. Radiographics. 41(2):462-86, 2021
                                              2. Expert Panel on Interventional Radiology et al: ACR Appropriateness Criteria® radiologic management of urinary tract obstruction. J Am Coll Radiol. 17(5S):S281-92, 2020
                                              3. Villanueva J et al: Point-of-care ultrasound is an accurate, time-saving, and cost-effective modality for post-operative imaging after pyeloplasty. J Pediatr Urol. 16(4):472.e1-6, 2020
                                              4. Bedoya MA et al: Relationship of renal apparent diffusion coefficient and functional MR urography in children with pelvicalyceal dilation. Pediatr Radiol. 49(8):1032-41, 2019
                                              5. Gnech M et al: Pyeloplasty vs. nephrectomy for ureteropelvic junction obstruction in poorly functioning kidneys (differential renal function < 20%): a multicentric study. J Pediatr Urol. 15(5):553.e1-3.e8, 2019
                                              6. Sertorio F et al: Non-contrast-enhanced magnetic resonance angiography for detecting crossing renal vessels in infants and young children: comparison with contrast-enhanced angiography and surgical findings. Pediatr Radiol. 49(1):105-13, 2019
                                              7. Wong MCY et al: Surgical validation of functional magnetic resonance urography in the study of ureteropelvic junction obstruction in a pediatric cohort. J Pediatr Urol. 15(2):168-75, 2019
                                              8. Carpenter CP et al: Hydronephrosis after pyeloplasty: "will it go away?" urology. 121:158-63, 2018
                                              9. Morin CE et al: Use of MR urography in pediatric patients. Curr Urol Rep. 19(11):93, 2018
                                              10. Wong MCY et al: Hydronephrosis and crossing vessels in children: optimization of diagnostic-therapeutic pathway and analysis of color Doppler ultrasound and magnetic resonance urography diagnostic accuracy. J Pediatr Urol. 14(1):68.e1-6, 2018
                                              11. Habibi HA et al: Acoustic radiation force impulse (ARFI) elastography in the evaluation of renal parenchymal stiffness in patients with ureteropelvic junction obstruction. J Med Ultrason (2001). 44(2):167-72, 2017
                                              12. Menon P et al: Outcome analysis of pediatric pyeloplasty in units with less than 20% differential renal function. J Pediatr Urol. 12(3):171.e1-7, 2016
                                              13. Senol C et al: Changes in Cajal cell density in ureteropelvic junction obstruction in children. J Pediatr Urol. 12(2):89.e1-5, 2016
                                              14. Brucher N et al: Non-contrast-enhanced MR angiography using time-spin labelling inversion pulse technique for detecting crossing renal vessels in children with symptomatic ureteropelvic junction obstruction: comparison with surgical findings. Eur Radiol. 26(8):2697-704, 2015
                                              15. Li R et al: Diagnosis and management of ureteral fibroepithelial polyps in children: a new treatment algorithm. J Pediatr Urol. 11(1):22.e1-6, 2015
                                              16. Menon P et al: Hydronephrosis: comparison of extrinsic vessel versus intrinsic ureteropelvic junction obstruction groups and a plea against the vascular hitch procedure. J Pediatr Urol. 11(2):80.e1-6, 2015
                                              17. Parikh KR et al: Pediatric ureteropelvic junction obstruction: can magnetic resonance urography identify crossing vessels? Pediatr Radiol. 45(12):1788-95, 2015
                                              18. Cutroneo G et al: Altered cytoskeletal structure of smooth muscle cells in ureteropelvic junction obstruction. J Urol. 185(6):2314-9, 2011
                                              19. Mei H et al: Laparoscopic versus open pyeloplasty for ureteropelvic junction obstruction in children: a systematic review and meta-analysis. J Endourol. 25(5):727-36, 2011
                                              20. Samarasekera D et al: Endopyelotomy still has an important role in the management of ureteropelvic junction obstruction. Can Urol Assoc J. 5(2):134-6, 2011
                                              21. Wu Z et al: Novel method for double-J stenting in retroperitoneal laparoscopic dismembered pyeloplasty. Urology. 77(2):354-6, 2011
                                              22. Baek M et al: Long-term outcomes of dismembered pyeloplasty for midline-crossing giant hydronephrosis caused by ureteropelvic junction obstruction in children. Urology. 76(6):1463-7, 2010
                                              23. Szavay PO et al: Functional outcome after laparoscopic dismembered pyeloplasty in children. J Pediatr Urol. 6(4):359-63, 2010
                                              24. Richstone L et al: Pathologic findings in patients with ureteropelvic junction obstruction and crossing vessels. Urology. 73(4):716-9; discussion 719, 2009
                                              25. VanderBrink BA et al: Reconstructive surgery for lower pole ureteropelvic junction obstruction associated with incomplete ureteral duplication. J Pediatr Urol. 5(5):374-7, 2009
                                              26. Khaira HS et al: Helical computed tomography for identification of crossing vessels in ureteropelvic junction obstruction-comparison with operative findings. Urology. 62(1):35-9, 2003
                                              27. Brkljacic B et al: Doppler sonographic renal resistance index and resistance index ratio in children and adolescents with unilateral hydronephrosis. Eur Radiol. 12(11):2747-51, 2002
                                              28. Rooks VJ et al: Extrinsic ureteropelvic junction obstruction from a crossing renal vessel: demography and imaging. Pediatr Radiol. 31(2):120-4, 2001
                                              29. Frauscher F et al: Crossing vessels at the ureteropelvic junction: detection with contrast-enhanced color Doppler imaging. Radiology. 210(3):727-31, 1999
                                              30. Amling CL et al: Renal ultrasound changes after pyeloplasty in children with ureteropelvic junction obstruction: long-term outcome in 47 renal units. J Urol. 156(6):2020-4, 1996
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • Pelviureteric obstruction
                                                      • Definitions

                                                        • Ureteropelvic junction (UPJ) obstruction: Variable degree of blockage to urine flow at level of UPJ
                                                        • Most common urinary tract obstruction in pediatrics
                                                        • May be diagnosed antenatally with sonography or present in infancy or later childhood with urinary tract infection, intermittent abdominal pain, vomiting, &/or hematuria
                                                          • Occasionally found incidentally during trauma work-up

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • Ultrasonographic Findings

                                                            • Fluoroscopic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Other Modality Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          Selected References

                                                                                          1. Houat AP et al: Congenital anomalies of the upper urinary tract: a comprehensive review. Radiographics. 41(2):462-86, 2021
                                                                                          2. Expert Panel on Interventional Radiology et al: ACR Appropriateness Criteria® radiologic management of urinary tract obstruction. J Am Coll Radiol. 17(5S):S281-92, 2020
                                                                                          3. Villanueva J et al: Point-of-care ultrasound is an accurate, time-saving, and cost-effective modality for post-operative imaging after pyeloplasty. J Pediatr Urol. 16(4):472.e1-6, 2020
                                                                                          4. Bedoya MA et al: Relationship of renal apparent diffusion coefficient and functional MR urography in children with pelvicalyceal dilation. Pediatr Radiol. 49(8):1032-41, 2019
                                                                                          5. Gnech M et al: Pyeloplasty vs. nephrectomy for ureteropelvic junction obstruction in poorly functioning kidneys (differential renal function < 20%): a multicentric study. J Pediatr Urol. 15(5):553.e1-3.e8, 2019
                                                                                          6. Sertorio F et al: Non-contrast-enhanced magnetic resonance angiography for detecting crossing renal vessels in infants and young children: comparison with contrast-enhanced angiography and surgical findings. Pediatr Radiol. 49(1):105-13, 2019
                                                                                          7. Wong MCY et al: Surgical validation of functional magnetic resonance urography in the study of ureteropelvic junction obstruction in a pediatric cohort. J Pediatr Urol. 15(2):168-75, 2019
                                                                                          8. Carpenter CP et al: Hydronephrosis after pyeloplasty: "will it go away?" urology. 121:158-63, 2018
                                                                                          9. Morin CE et al: Use of MR urography in pediatric patients. Curr Urol Rep. 19(11):93, 2018
                                                                                          10. Wong MCY et al: Hydronephrosis and crossing vessels in children: optimization of diagnostic-therapeutic pathway and analysis of color Doppler ultrasound and magnetic resonance urography diagnostic accuracy. J Pediatr Urol. 14(1):68.e1-6, 2018
                                                                                          11. Habibi HA et al: Acoustic radiation force impulse (ARFI) elastography in the evaluation of renal parenchymal stiffness in patients with ureteropelvic junction obstruction. J Med Ultrason (2001). 44(2):167-72, 2017
                                                                                          12. Menon P et al: Outcome analysis of pediatric pyeloplasty in units with less than 20% differential renal function. J Pediatr Urol. 12(3):171.e1-7, 2016
                                                                                          13. Senol C et al: Changes in Cajal cell density in ureteropelvic junction obstruction in children. J Pediatr Urol. 12(2):89.e1-5, 2016
                                                                                          14. Brucher N et al: Non-contrast-enhanced MR angiography using time-spin labelling inversion pulse technique for detecting crossing renal vessels in children with symptomatic ureteropelvic junction obstruction: comparison with surgical findings. Eur Radiol. 26(8):2697-704, 2015
                                                                                          15. Li R et al: Diagnosis and management of ureteral fibroepithelial polyps in children: a new treatment algorithm. J Pediatr Urol. 11(1):22.e1-6, 2015
                                                                                          16. Menon P et al: Hydronephrosis: comparison of extrinsic vessel versus intrinsic ureteropelvic junction obstruction groups and a plea against the vascular hitch procedure. J Pediatr Urol. 11(2):80.e1-6, 2015
                                                                                          17. Parikh KR et al: Pediatric ureteropelvic junction obstruction: can magnetic resonance urography identify crossing vessels? Pediatr Radiol. 45(12):1788-95, 2015
                                                                                          18. Cutroneo G et al: Altered cytoskeletal structure of smooth muscle cells in ureteropelvic junction obstruction. J Urol. 185(6):2314-9, 2011
                                                                                          19. Mei H et al: Laparoscopic versus open pyeloplasty for ureteropelvic junction obstruction in children: a systematic review and meta-analysis. J Endourol. 25(5):727-36, 2011
                                                                                          20. Samarasekera D et al: Endopyelotomy still has an important role in the management of ureteropelvic junction obstruction. Can Urol Assoc J. 5(2):134-6, 2011
                                                                                          21. Wu Z et al: Novel method for double-J stenting in retroperitoneal laparoscopic dismembered pyeloplasty. Urology. 77(2):354-6, 2011
                                                                                          22. Baek M et al: Long-term outcomes of dismembered pyeloplasty for midline-crossing giant hydronephrosis caused by ureteropelvic junction obstruction in children. Urology. 76(6):1463-7, 2010
                                                                                          23. Szavay PO et al: Functional outcome after laparoscopic dismembered pyeloplasty in children. J Pediatr Urol. 6(4):359-63, 2010
                                                                                          24. Richstone L et al: Pathologic findings in patients with ureteropelvic junction obstruction and crossing vessels. Urology. 73(4):716-9; discussion 719, 2009
                                                                                          25. VanderBrink BA et al: Reconstructive surgery for lower pole ureteropelvic junction obstruction associated with incomplete ureteral duplication. J Pediatr Urol. 5(5):374-7, 2009
                                                                                          26. Khaira HS et al: Helical computed tomography for identification of crossing vessels in ureteropelvic junction obstruction-comparison with operative findings. Urology. 62(1):35-9, 2003
                                                                                          27. Brkljacic B et al: Doppler sonographic renal resistance index and resistance index ratio in children and adolescents with unilateral hydronephrosis. Eur Radiol. 12(11):2747-51, 2002
                                                                                          28. Rooks VJ et al: Extrinsic ureteropelvic junction obstruction from a crossing renal vessel: demography and imaging. Pediatr Radiol. 31(2):120-4, 2001
                                                                                          29. Frauscher F et al: Crossing vessels at the ureteropelvic junction: detection with contrast-enhanced color Doppler imaging. Radiology. 210(3):727-31, 1999
                                                                                          30. Amling CL et al: Renal ultrasound changes after pyeloplasty in children with ureteropelvic junction obstruction: long-term outcome in 47 renal units. J Urol. 156(6):2020-4, 1996