Malignant uterine neoplasm composed of both carcinomatous (epithelial) and sarcomatous (mesenchymal) components
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bi Q et al: The value of clinical parameters combined with magnetic resonance imaging (MRI) features for preoperatively distinguishing different subtypes of uterine sarcomas: an observational study (STROBE compliant). Medicine (Baltimore). 99(16):e19787, 2020
Abdulfatah E et al: Predictive histologic factors in carcinosarcomas of the uterus: a multi-institutional study. Int J Gynecol Pathol. 38(3):205-15, 2019
Cuevas IC et al: Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 116(51):25880-90, 2019
Huang YT et al: Current status of magnetic resonance imaging in patients with malignant uterine neoplasms: a review. Korean J Radiol. 20(1):18-33, 2019
Kurnit KC et al: Prognostic factors impacting survival in early stage uterine carcinosarcoma. Gynecol Oncol. 152(1):31-7, 2019
Li Y et al: Outcome of adjuvant radiotherapy after total hysterectomy in patients with uterine leiomyosarcoma or carcinosarcoma: a SEER-based study. BMC Cancer. 19(1):697, 2019
Sagebiel TL et al: Uterine carcinosarcomas. Semin Ultrasound CT MR. 40(4):295-301, 2019
Denschlag D et al: Uterine carcinosarcomas - diagnosis and management. Oncol Res Treat. 41(11):675-9, 2018
Jantarasaengaram S et al: Three-dimensional ultrasound with volume contrast imaging for preoperative assessment of myometrial invasion and cervical involvement in women with endometrial cancer. Ultrasound Obstet Gynecol. 43(5):569-74, 2014
Anupama R et al: Carcinosarcoma of the uterus-a single institution retrospective analysis of the management and outcome and a brief review of literature. Indian J Surg Oncol. 4(3):222-8, 2013
Guntupalli SR et al: Wilms' tumor 1 protein and estrogen receptor beta expression are associated with poor outcomes in uterine carcinosarcoma. Ann Surg Oncol. 20(7):2373-9, 2013
Lopez-Chardi L et al: Mesonephric carcinosarcoma of the uterine cervix: a case report. Eur J Gynaecol Oncol. 34(4):336-8, 2013
Machida H et al: Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. Eur J Gynaecol Oncol. 34(4):291-5, 2013
Pacaut C et al: Uterine and ovary carcinosarcomas: outcome, prognosis factors, and adjuvant therapy. Am J Clin Oncol. 38(3):272-7, 2013
Rauh-Hain JA et al: Prognostic determinants in patients with uterine and ovarian carcinosarcoma. J Reprod Med. 58(7-8):297-304, 2013
Saglam O et al: AKT, EGFR, C-ErbB-2, and C-kit expression in uterine carcinosarcoma. Int J Gynecol Pathol. 32(5):493-500, 2013
Tasic L et al: Carcinosarcoma of the uterus in advanced stage: a case report. Eur J Gynaecol Oncol. 34(4):343-6, 2013
Wu YC et al: Intramural metastases of rectum from carcinosarcoma (malignant müllerian mixed tumor) of uterine cervix. Clin Nucl Med. 38(2):137-9, 2013
Lee EJ et al: Malignant mixed Müllerian tumors of the uterus: sonographic spectrum. Ultrasound Obstet Gynecol. 39(3):348-53, 2012
Shah SH et al: Uterine sarcomas: then and now. AJR Am J Roentgenol. 199(1):213-23, 2012
Tropé CG et al: Diagnosis and treatment of sarcoma of the uterus. A review. Acta Oncol. 51(6):694-705, 2012
Genever AV et al: Can MRI predict the diagnosis of endometrial carcinosarcoma? Clin Radiol. 66(7):621-4, 2011
Bharwani N et al: MRI appearances of uterine malignant mixed müllerian tumors. AJR Am J Roentgenol. 195(5):1268-75, 2010
Kato H et al: Carcinosarcoma of the uterus: radiologic-pathologic correlations with magnetic resonance imaging including diffusion-weighted imaging. Magn Reson Imaging. 26(10):1446-50, 2008
Spaziani E et al: Carcinosarcoma of the uterus: a case report and review of the literature. Eur J Gynaecol Oncol. 29(5):531-4, 2008
Tanaka YO et al: Carcinosarcoma of the uterus: MR findings. J Magn Reson Imaging. 28(2):434-9, 2008
Teo SY et al: Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. AJR Am J Roentgenol. 191(1):278-83, 2008
Huang GS et al: Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma. Gynecol Oncol. 107(3):513-7, 2007
Takeuchi M et al: Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging. Eur Radiol. 15(11):2244-55, 2005
Callister M et al: Malignant mixed Mullerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. Int J Radiat Oncol Biol Phys. 58(3):786-96, 2004
Chaudhry S et al: Benign and malignant diseases of the endometrium. Top Magn Reson Imaging. 14(4):339-57, 2003
Kido A et al: Diffusely enlarged uterus: evaluation with MR imaging. Radiographics. 23(6):1423-39, 2003
Rha SE et al: CT and MRI of uterine sarcomas and their mimickers. AJR Am J Roentgenol. 181(5):1369-74, 2003
Szklaruk J et al: MR imaging of common and uncommon large pelvic masses. Radiographics. 23(2):403-24, 2003
Inthasorn P et al: Analysis of clinicopathologic factors in malignant mixed Mullerian tumors of the uterine corpus. Int J Gynecol Cancer. 12(4):348-53, 2002
Ohguri T et al: MRI findings including gadolinium-enhanced dynamic studies of malignant, mixed mesodermal tumors of the uterus: differentiation from endometrial carcinomas. Eur Radiol. 12(11):2737-42, 2002
Sahdev A et al: MR imaging of uterine sarcomas. AJR Am J Roentgenol. 177(6):1307-11, 2001
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Malignant mixed müllerian tumor
Malignant mixed mesodermal tumor
Definitions
Malignant uterine neoplasm composed of both carcinomatous (epithelial) and sarcomatous (mesenchymal) components
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bi Q et al: The value of clinical parameters combined with magnetic resonance imaging (MRI) features for preoperatively distinguishing different subtypes of uterine sarcomas: an observational study (STROBE compliant). Medicine (Baltimore). 99(16):e19787, 2020
Abdulfatah E et al: Predictive histologic factors in carcinosarcomas of the uterus: a multi-institutional study. Int J Gynecol Pathol. 38(3):205-15, 2019
Cuevas IC et al: Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 116(51):25880-90, 2019
Huang YT et al: Current status of magnetic resonance imaging in patients with malignant uterine neoplasms: a review. Korean J Radiol. 20(1):18-33, 2019
Kurnit KC et al: Prognostic factors impacting survival in early stage uterine carcinosarcoma. Gynecol Oncol. 152(1):31-7, 2019
Li Y et al: Outcome of adjuvant radiotherapy after total hysterectomy in patients with uterine leiomyosarcoma or carcinosarcoma: a SEER-based study. BMC Cancer. 19(1):697, 2019
Sagebiel TL et al: Uterine carcinosarcomas. Semin Ultrasound CT MR. 40(4):295-301, 2019
Denschlag D et al: Uterine carcinosarcomas - diagnosis and management. Oncol Res Treat. 41(11):675-9, 2018
Jantarasaengaram S et al: Three-dimensional ultrasound with volume contrast imaging for preoperative assessment of myometrial invasion and cervical involvement in women with endometrial cancer. Ultrasound Obstet Gynecol. 43(5):569-74, 2014
Anupama R et al: Carcinosarcoma of the uterus-a single institution retrospective analysis of the management and outcome and a brief review of literature. Indian J Surg Oncol. 4(3):222-8, 2013
Guntupalli SR et al: Wilms' tumor 1 protein and estrogen receptor beta expression are associated with poor outcomes in uterine carcinosarcoma. Ann Surg Oncol. 20(7):2373-9, 2013
Lopez-Chardi L et al: Mesonephric carcinosarcoma of the uterine cervix: a case report. Eur J Gynaecol Oncol. 34(4):336-8, 2013
Machida H et al: Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. Eur J Gynaecol Oncol. 34(4):291-5, 2013
Pacaut C et al: Uterine and ovary carcinosarcomas: outcome, prognosis factors, and adjuvant therapy. Am J Clin Oncol. 38(3):272-7, 2013
Rauh-Hain JA et al: Prognostic determinants in patients with uterine and ovarian carcinosarcoma. J Reprod Med. 58(7-8):297-304, 2013
Saglam O et al: AKT, EGFR, C-ErbB-2, and C-kit expression in uterine carcinosarcoma. Int J Gynecol Pathol. 32(5):493-500, 2013
Tasic L et al: Carcinosarcoma of the uterus in advanced stage: a case report. Eur J Gynaecol Oncol. 34(4):343-6, 2013
Wu YC et al: Intramural metastases of rectum from carcinosarcoma (malignant müllerian mixed tumor) of uterine cervix. Clin Nucl Med. 38(2):137-9, 2013
Lee EJ et al: Malignant mixed Müllerian tumors of the uterus: sonographic spectrum. Ultrasound Obstet Gynecol. 39(3):348-53, 2012
Shah SH et al: Uterine sarcomas: then and now. AJR Am J Roentgenol. 199(1):213-23, 2012
Tropé CG et al: Diagnosis and treatment of sarcoma of the uterus. A review. Acta Oncol. 51(6):694-705, 2012
Genever AV et al: Can MRI predict the diagnosis of endometrial carcinosarcoma? Clin Radiol. 66(7):621-4, 2011
Bharwani N et al: MRI appearances of uterine malignant mixed müllerian tumors. AJR Am J Roentgenol. 195(5):1268-75, 2010
Kato H et al: Carcinosarcoma of the uterus: radiologic-pathologic correlations with magnetic resonance imaging including diffusion-weighted imaging. Magn Reson Imaging. 26(10):1446-50, 2008
Spaziani E et al: Carcinosarcoma of the uterus: a case report and review of the literature. Eur J Gynaecol Oncol. 29(5):531-4, 2008
Tanaka YO et al: Carcinosarcoma of the uterus: MR findings. J Magn Reson Imaging. 28(2):434-9, 2008
Teo SY et al: Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. AJR Am J Roentgenol. 191(1):278-83, 2008
Huang GS et al: Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma. Gynecol Oncol. 107(3):513-7, 2007
Takeuchi M et al: Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging. Eur Radiol. 15(11):2244-55, 2005
Callister M et al: Malignant mixed Mullerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. Int J Radiat Oncol Biol Phys. 58(3):786-96, 2004
Chaudhry S et al: Benign and malignant diseases of the endometrium. Top Magn Reson Imaging. 14(4):339-57, 2003
Kido A et al: Diffusely enlarged uterus: evaluation with MR imaging. Radiographics. 23(6):1423-39, 2003
Rha SE et al: CT and MRI of uterine sarcomas and their mimickers. AJR Am J Roentgenol. 181(5):1369-74, 2003
Szklaruk J et al: MR imaging of common and uncommon large pelvic masses. Radiographics. 23(2):403-24, 2003
Inthasorn P et al: Analysis of clinicopathologic factors in malignant mixed Mullerian tumors of the uterine corpus. Int J Gynecol Cancer. 12(4):348-53, 2002
Ohguri T et al: MRI findings including gadolinium-enhanced dynamic studies of malignant, mixed mesodermal tumors of the uterus: differentiation from endometrial carcinomas. Eur Radiol. 12(11):2737-42, 2002
Sahdev A et al: MR imaging of uterine sarcomas. AJR Am J Roentgenol. 177(6):1307-11, 2001
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