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Vaginal Paraganglioma
Christine O. Menias, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Vaginal pheochromocytoma
          • Definitions

            • Catecholamine-secreting tumor that arises from chromaffin cells of sympathoadrenal system
            • Extraadrenal neuroendocrine neoplasms derived from neural crest precursors
            • Rare tumor of genital tract
              • Can occur in ovary, cervix, and vagina

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Imaging Recommendations

                    • Nuclear Medicine Findings

                      • PET/CT

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              CLINICAL ISSUES

                              • Presentation

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Rana HQ et al: Genetic testing in the clinical care of patients with pheochromocytoma and paraganglioma. Curr Opin Endocrinol Diabetes Obes. 21(3):166-76, 2014
                                      2. Shuch B et al: The genetic basis of pheochromocytoma and paraganglioma: implications for management. Urology. 83(6):1225-32, 2014
                                      3. Tsirlin A et al: Pheochromocytoma: a review. Maturitas. 77(3):229-38, 2014
                                      4. van Berkel A et al: Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma. Eur J Endocrinol. 170(3):R109-19, 2014
                                      5. Aktolun C et al: Diagnostic and therapeutic use of MIBG in pheochromocytoma and paraganglioma. Q J Nucl Med Mol Imaging. 57(2):109-11, 2013
                                      6. Dahia PL: Novel hereditary forms of pheochromocytomas and paragangliomas. Front Horm Res. 41:79-91, 2013
                                      7. Fussey JM et al: Vaginoplasty: a modern approach: a report of 2 cases. J Reprod Med. 58(9-10):441-4, 2013
                                      8. Ilha MR et al: Extra-adrenal retroperitoneal paraganglioma in a dog. J Vet Diagn Invest. 25(6):803-6, 2013
                                      9. Kapoor G et al: Phaeochromocytoma in pregnancy: safe vaginal delivery, is it possible? J Indian Med Assoc. 111(4):266-7, 2013
                                      10. Kumar U M et al: An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. J Clin Diagn Res. 7(6):1177-9, 2013
                                      11. Papathomas TG et al: Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments. Semin Diagn Pathol. 30(3):207-23, 2013
                                      12. Rufini V et al: Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review. Q J Nucl Med Mol Imaging. 57(2):122-33, 2013
                                      13. Asfaw TS et al: Utility of preoperative examination and magnetic resonance imaging for diagnosis of anterior vaginal wall masses. Int Urogynecol J. 23(8):1055-61, 2012
                                      14. Akl MN et al: Vaginal paraganglioma presenting as a pelvic mass. Surgery. 147(1):169-71, 2010
                                      15. Shen JG et al: Vaginal paraganglioma presenting as a gynecologic mass: case report. Eur J Gynaecol Oncol. 29(2):184-5, 2008
                                      16. Brustmann H: Paraganglioma of the vagina: report of a case. Pathol Res Pract. 203(3):189-92, 2007
                                      17. Elsayes KM et al: Vaginal masses: magnetic resonance imaging features with pathologic correlation. Acta Radiol. 48(8):921-33, 2007
                                      18. Hassan A et al: Paraganglioma of the vagina: report of a case, including immunohistochemical and ultrastructural findings. Int J Gynecol Pathol. 22(4):404-6, 2003
                                      19. Lyman DJ: Paroxysmal hypertension, pheochromocytoma, and pregnancy. J Am Board Fam Pract. 15(2):153-8, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Vaginal pheochromocytoma
                                              • Definitions

                                                • Catecholamine-secreting tumor that arises from chromaffin cells of sympathoadrenal system
                                                • Extraadrenal neuroendocrine neoplasms derived from neural crest precursors
                                                • Rare tumor of genital tract
                                                  • Can occur in ovary, cervix, and vagina

                                              IMAGING

                                              • General Features

                                                • CT Findings

                                                  • MR Findings

                                                    • Ultrasonographic Findings

                                                      • Imaging Recommendations

                                                        • Nuclear Medicine Findings

                                                          • PET/CT

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • Staging, Grading, & Classification

                                                                • Gross Pathologic & Surgical Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Rana HQ et al: Genetic testing in the clinical care of patients with pheochromocytoma and paraganglioma. Curr Opin Endocrinol Diabetes Obes. 21(3):166-76, 2014
                                                                          2. Shuch B et al: The genetic basis of pheochromocytoma and paraganglioma: implications for management. Urology. 83(6):1225-32, 2014
                                                                          3. Tsirlin A et al: Pheochromocytoma: a review. Maturitas. 77(3):229-38, 2014
                                                                          4. van Berkel A et al: Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma. Eur J Endocrinol. 170(3):R109-19, 2014
                                                                          5. Aktolun C et al: Diagnostic and therapeutic use of MIBG in pheochromocytoma and paraganglioma. Q J Nucl Med Mol Imaging. 57(2):109-11, 2013
                                                                          6. Dahia PL: Novel hereditary forms of pheochromocytomas and paragangliomas. Front Horm Res. 41:79-91, 2013
                                                                          7. Fussey JM et al: Vaginoplasty: a modern approach: a report of 2 cases. J Reprod Med. 58(9-10):441-4, 2013
                                                                          8. Ilha MR et al: Extra-adrenal retroperitoneal paraganglioma in a dog. J Vet Diagn Invest. 25(6):803-6, 2013
                                                                          9. Kapoor G et al: Phaeochromocytoma in pregnancy: safe vaginal delivery, is it possible? J Indian Med Assoc. 111(4):266-7, 2013
                                                                          10. Kumar U M et al: An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. J Clin Diagn Res. 7(6):1177-9, 2013
                                                                          11. Papathomas TG et al: Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments. Semin Diagn Pathol. 30(3):207-23, 2013
                                                                          12. Rufini V et al: Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review. Q J Nucl Med Mol Imaging. 57(2):122-33, 2013
                                                                          13. Asfaw TS et al: Utility of preoperative examination and magnetic resonance imaging for diagnosis of anterior vaginal wall masses. Int Urogynecol J. 23(8):1055-61, 2012
                                                                          14. Akl MN et al: Vaginal paraganglioma presenting as a pelvic mass. Surgery. 147(1):169-71, 2010
                                                                          15. Shen JG et al: Vaginal paraganglioma presenting as a gynecologic mass: case report. Eur J Gynaecol Oncol. 29(2):184-5, 2008
                                                                          16. Brustmann H: Paraganglioma of the vagina: report of a case. Pathol Res Pract. 203(3):189-92, 2007
                                                                          17. Elsayes KM et al: Vaginal masses: magnetic resonance imaging features with pathologic correlation. Acta Radiol. 48(8):921-33, 2007
                                                                          18. Hassan A et al: Paraganglioma of the vagina: report of a case, including immunohistochemical and ultrastructural findings. Int J Gynecol Pathol. 22(4):404-6, 2003
                                                                          19. Lyman DJ: Paroxysmal hypertension, pheochromocytoma, and pregnancy. J Am Board Fam Pract. 15(2):153-8, 2002