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Vaginal Yolk Sac Tumor
Akram M. Shaaban, MBBCh; Olga Hatsiopoulou, MD, FRCR; Evis Sala, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Yolk sac tumor (YST)
            • Synonyms

              • Endodermal sinus tumor
            • Definitions

              • Primary malignant germ cell tumor of vagina

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Goyal S et al: Endodermal sinus tumor of vagina posing a diagnostic challenge and managed by chemotherapy and novel posterior sagittal surgical approach: lessons learned. J Obstet Gynaecol Res. 40(2):632-6, 2014
                                        2. Sudour-Bonnange H et al: Germ cell tumors in atypical locations: experience of the TGM 95 SFCE trial. J Pediatr Hematol Oncol. 36(8):646-8, 2014
                                        3. Chauhan S et al: Endodermal sinus tumor of vagina in infants. Rare Tumors. 5(2):83-4, 2013
                                        4. Liu QY et al: Clinical manifestations and MRI features of vaginal endodermal sinus tumors in four children. Pediatr Radiol. 43(8):983-90, 2013
                                        5. Arafah M et al: A case of yolk sac tumor of the vagina in an infant. Arch Gynecol Obstet. 285(5):1403-5, 2012
                                        6. Dhanasekharan A et al: Endodermal sinus tumor of the vagina in a child. J Obstet Gynaecol India. 62(Suppl 1):81-2, 2012
                                        7. Mardi K et al: Primary yolk sac tumor of cervix and vagina in an adult female: a rare case report. Indian J Cancer. 48(4):515-6, 2011
                                        8. Wani NA et al: Vaginal yolk sac tumor causing infantile hydrometra: use of multidetector-row computed tomography. J Pediatr Adolesc Gynecol. 23(3):e115-8, 2010
                                        9. Watanabe N et al: Vaginal yolk sac (endodermal sinus) tumors in infancy presenting persistent vaginal bleeding. J Obstet Gynaecol Res. 36(1):213-6, 2010
                                        10. Gangopadhyay M et al: Endodermal sinus tumor of the vagina in children: a report of two cases. Indian J Pathol Microbiol. 52(3):403-4, 2009
                                        11. Mahzouni P et al: Yolk sac tumor of the vagina. Saudi Med J. 28(7):1125-6, 2007
                                        12. Deshmukh C et al: Yolk sac tumor of vagina. Indian J Pediatr. 72(4):367, 2005
                                        13. Kumar V et al: Vaginal endodermal sinus tumor. Indian J Pediatr. 72(9):797-8, 2005
                                        14. Chatterjee U et al: Endodermal sinus tumor of vagina. J Indian Assoc Pediatr Surg. 8:235-8, 2003
                                        15. Grygotis LA et al: Endodermal sinus tumor of the vagina. AJR Am J Roentgenol. 169(6):1632, 1997
                                        16. Imai A et al: Endodermal sinus tumor of the vagina in an infant: magnetic resonance imaging evaluation. Gynecol Oncol. 48(3):402-5, 1993
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Yolk sac tumor (YST)
                                                  • Synonyms

                                                    • Endodermal sinus tumor
                                                  • Definitions

                                                    • Primary malignant germ cell tumor of vagina

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Goyal S et al: Endodermal sinus tumor of vagina posing a diagnostic challenge and managed by chemotherapy and novel posterior sagittal surgical approach: lessons learned. J Obstet Gynaecol Res. 40(2):632-6, 2014
                                                                              2. Sudour-Bonnange H et al: Germ cell tumors in atypical locations: experience of the TGM 95 SFCE trial. J Pediatr Hematol Oncol. 36(8):646-8, 2014
                                                                              3. Chauhan S et al: Endodermal sinus tumor of vagina in infants. Rare Tumors. 5(2):83-4, 2013
                                                                              4. Liu QY et al: Clinical manifestations and MRI features of vaginal endodermal sinus tumors in four children. Pediatr Radiol. 43(8):983-90, 2013
                                                                              5. Arafah M et al: A case of yolk sac tumor of the vagina in an infant. Arch Gynecol Obstet. 285(5):1403-5, 2012
                                                                              6. Dhanasekharan A et al: Endodermal sinus tumor of the vagina in a child. J Obstet Gynaecol India. 62(Suppl 1):81-2, 2012
                                                                              7. Mardi K et al: Primary yolk sac tumor of cervix and vagina in an adult female: a rare case report. Indian J Cancer. 48(4):515-6, 2011
                                                                              8. Wani NA et al: Vaginal yolk sac tumor causing infantile hydrometra: use of multidetector-row computed tomography. J Pediatr Adolesc Gynecol. 23(3):e115-8, 2010
                                                                              9. Watanabe N et al: Vaginal yolk sac (endodermal sinus) tumors in infancy presenting persistent vaginal bleeding. J Obstet Gynaecol Res. 36(1):213-6, 2010
                                                                              10. Gangopadhyay M et al: Endodermal sinus tumor of the vagina in children: a report of two cases. Indian J Pathol Microbiol. 52(3):403-4, 2009
                                                                              11. Mahzouni P et al: Yolk sac tumor of the vagina. Saudi Med J. 28(7):1125-6, 2007
                                                                              12. Deshmukh C et al: Yolk sac tumor of vagina. Indian J Pediatr. 72(4):367, 2005
                                                                              13. Kumar V et al: Vaginal endodermal sinus tumor. Indian J Pediatr. 72(9):797-8, 2005
                                                                              14. Chatterjee U et al: Endodermal sinus tumor of vagina. J Indian Assoc Pediatr Surg. 8:235-8, 2003
                                                                              15. Grygotis LA et al: Endodermal sinus tumor of the vagina. AJR Am J Roentgenol. 169(6):1632, 1997
                                                                              16. Imai A et al: Endodermal sinus tumor of the vagina in an infant: magnetic resonance imaging evaluation. Gynecol Oncol. 48(3):402-5, 1993