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Varicella
Janice L. B. Byrne, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Varicella-zoster virus (VZV)
            • Synonyms

              • Fetal varicella syndrome/embryopathy
            • Definitions

              • Transplacental infection of fetus following maternal chickenpox infection
                • Highest risk when acquired at 8- to 20-weeks gestation

            IMAGING

            • Ultrasonographic Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            Selected References

                            1. Mandelbrot L: Fetal varicella - diagnosis, management, and outcome. Prenat Diagn. 32(6):511-8, 2012
                            2. Tongsong T et al: Prenatal sonographic diagnosis of congenital varicella syndrome. J Clin Ultrasound. 40(3):176-8, 2012
                            3. Lamont RF et al: Varicella-zoster virus (chickenpox) infection in pregnancy. BJOG. 118(10):1155-62, 2011
                            4. Sanchez MA et al: The prevalence of congenital varicella syndrome after a maternal infection, but before 20 weeks of pregnancy: a prospective cohort study. J Matern Fetal Neonatal Med. 24(2):341-7, 2011
                            5. Auriti C et al: Congenital varicella syndrome: still a problem? Fetal Diagn Ther. 25(2):224-9, 2009
                            6. Smith CK et al: Varicella in the fetus and newborn. Semin Fetal Neonatal Med. 14(4):209-17, 2009
                            7. Daley AJ et al: Varicella and the pregnant woman: prevention and management. Aust N Z J Obstet Gynaecol. 48(1):26-33, 2008
                            8. Sauerbrei A et al: Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infections. Med Microbiol Immunol. 196(2):89-94, 2007
                            9. Meyberg-Solomayer GC et al: Prenatal ultrasound diagnosis, follow-up, and outcome of congenital varicella syndrome. Fetal Diagn Ther. 21(3):296-301, 2006
                            10. Tan MP et al: Chickenpox in pregnancy: revisited. Reprod Toxicol. 21(4):410-20, 2006
                            11. Al-Katawee YA et al: Congenital varicella-zoster virus infection. A rare case of severe brain and ocular malformations without limb or cutaneous involvement in a newborn after maternal subclinical infection. Saudi Med J. 26(5):869-71, 2005
                            12. Chickenpox, pregnancy and the newborn: a follow-up. Drug Ther Bull. 43(12):94-5, 2005
                            13. Fernández-Aguilar S et al: Congenital pulmonary airway malformation and congenital varicella infection-a possible association. Ultrasound Obstet Gynecol. 26(6):680-2, 2005
                            14. Mattson SN et al: Neurodevelopmental follow-up of children of women infected with varicella during pregnancy: a prospective study. Pediatr Infect Dis J. 22(9):819-23, 2003
                            15. Verstraelen H et al: Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings. Prenat Diagn. 23(9):705-9, 2003
                            16. Heuchan AM et al: The management of varicella-zoster virus exposure and infection in pregnancy and the newborn period. Australasian Subgroup in Paediatric Infectious Diseases of the Australasian Society for Infectious Diseases. Med J Aust. 174(6):288-92, 2001
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Terminology

                              • Imaging

                                • Top Differential Diagnoses

                                  • Pathology

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Abbreviations

                                        • Varicella-zoster virus (VZV)
                                      • Synonyms

                                        • Fetal varicella syndrome/embryopathy
                                      • Definitions

                                        • Transplacental infection of fetus following maternal chickenpox infection
                                          • Highest risk when acquired at 8- to 20-weeks gestation

                                      IMAGING

                                      • Ultrasonographic Findings

                                        • Imaging Recommendations

                                          DIFFERENTIAL DIAGNOSIS

                                            PATHOLOGY

                                            • General Features

                                              CLINICAL ISSUES

                                              • Presentation

                                                • Demographics

                                                  • Natural History & Prognosis

                                                    • Treatment

                                                      Selected References

                                                      1. Mandelbrot L: Fetal varicella - diagnosis, management, and outcome. Prenat Diagn. 32(6):511-8, 2012
                                                      2. Tongsong T et al: Prenatal sonographic diagnosis of congenital varicella syndrome. J Clin Ultrasound. 40(3):176-8, 2012
                                                      3. Lamont RF et al: Varicella-zoster virus (chickenpox) infection in pregnancy. BJOG. 118(10):1155-62, 2011
                                                      4. Sanchez MA et al: The prevalence of congenital varicella syndrome after a maternal infection, but before 20 weeks of pregnancy: a prospective cohort study. J Matern Fetal Neonatal Med. 24(2):341-7, 2011
                                                      5. Auriti C et al: Congenital varicella syndrome: still a problem? Fetal Diagn Ther. 25(2):224-9, 2009
                                                      6. Smith CK et al: Varicella in the fetus and newborn. Semin Fetal Neonatal Med. 14(4):209-17, 2009
                                                      7. Daley AJ et al: Varicella and the pregnant woman: prevention and management. Aust N Z J Obstet Gynaecol. 48(1):26-33, 2008
                                                      8. Sauerbrei A et al: Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infections. Med Microbiol Immunol. 196(2):89-94, 2007
                                                      9. Meyberg-Solomayer GC et al: Prenatal ultrasound diagnosis, follow-up, and outcome of congenital varicella syndrome. Fetal Diagn Ther. 21(3):296-301, 2006
                                                      10. Tan MP et al: Chickenpox in pregnancy: revisited. Reprod Toxicol. 21(4):410-20, 2006
                                                      11. Al-Katawee YA et al: Congenital varicella-zoster virus infection. A rare case of severe brain and ocular malformations without limb or cutaneous involvement in a newborn after maternal subclinical infection. Saudi Med J. 26(5):869-71, 2005
                                                      12. Chickenpox, pregnancy and the newborn: a follow-up. Drug Ther Bull. 43(12):94-5, 2005
                                                      13. Fernández-Aguilar S et al: Congenital pulmonary airway malformation and congenital varicella infection-a possible association. Ultrasound Obstet Gynecol. 26(6):680-2, 2005
                                                      14. Mattson SN et al: Neurodevelopmental follow-up of children of women infected with varicella during pregnancy: a prospective study. Pediatr Infect Dis J. 22(9):819-23, 2003
                                                      15. Verstraelen H et al: Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings. Prenat Diagn. 23(9):705-9, 2003
                                                      16. Heuchan AM et al: The management of varicella-zoster virus exposure and infection in pregnancy and the newborn period. Australasian Subgroup in Paediatric Infectious Diseases of the Australasian Society for Infectious Diseases. Med J Aust. 174(6):288-92, 2001