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Venoocclusive Disease
Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Hepatic venoocclusive disease (VOD)
          • Synonyms

            • Hepatic sinusoidal obstruction syndrome (preferred)
          • Definitions

            • Hepatic venous outflow obstruction due to occlusion of terminal hepatic venules and sinusoids

          IMAGING

          • CT Findings

            • MR Findings

              • Ultrasonographic Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Gao H et al: Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids. J Dig Dis. 13(1):33-9, 2012
                                  2. Jevtic D et al: Veno-occlusive disease in pediatric patients after hematopoietic stem cell transplantation: relevance of activated coagulation and fibrinolysis markers and natural anticoagulants. J Pediatr Hematol Oncol. 33(3):227-34, 2011
                                  3. Lin G et al: Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol. 54(4):666-73, 2011
                                  4. Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
                                  5. Menke J: Education and imaging. Hepatobiliary and pancreatic: sinusoidal obstruction syndrome during chemotherapy. J Gastroenterol Hepatol. 26(6):1083, 2011
                                  6. Sanei MH et al: Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites postliver transplantation. Transplantation. 92(10):1152-8, 2011
                                  7. Sebagh M et al: Significance of isolated hepatic veno-occlusive disease/sinusoidal obstruction syndrome after liver transplantation. Liver Transpl. 17(7):798-808, 2011
                                  8. Rubbia-Brandt L: Sinusoidal obstruction syndrome. Clin Liver Dis. 14(4):651-68, 2010
                                  9. Song MK et al: Hepatic artery resistance index at doppler ultrasonography is a useful parameter of hepatic graft-vs-host disease after allogeneic stem cell transplantation. Transplant Proc. 42(9):3717-22, 2010
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Hepatic venoocclusive disease (VOD)
                                          • Synonyms

                                            • Hepatic sinusoidal obstruction syndrome (preferred)
                                          • Definitions

                                            • Hepatic venous outflow obstruction due to occlusion of terminal hepatic venules and sinusoids

                                          IMAGING

                                          • CT Findings

                                            • MR Findings

                                              • Ultrasonographic Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Consider

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Gao H et al: Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids. J Dig Dis. 13(1):33-9, 2012
                                                                  2. Jevtic D et al: Veno-occlusive disease in pediatric patients after hematopoietic stem cell transplantation: relevance of activated coagulation and fibrinolysis markers and natural anticoagulants. J Pediatr Hematol Oncol. 33(3):227-34, 2011
                                                                  3. Lin G et al: Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol. 54(4):666-73, 2011
                                                                  4. Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
                                                                  5. Menke J: Education and imaging. Hepatobiliary and pancreatic: sinusoidal obstruction syndrome during chemotherapy. J Gastroenterol Hepatol. 26(6):1083, 2011
                                                                  6. Sanei MH et al: Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites postliver transplantation. Transplantation. 92(10):1152-8, 2011
                                                                  7. Sebagh M et al: Significance of isolated hepatic veno-occlusive disease/sinusoidal obstruction syndrome after liver transplantation. Liver Transpl. 17(7):798-808, 2011
                                                                  8. Rubbia-Brandt L: Sinusoidal obstruction syndrome. Clin Liver Dis. 14(4):651-68, 2010
                                                                  9. Song MK et al: Hepatic artery resistance index at doppler ultrasonography is a useful parameter of hepatic graft-vs-host disease after allogeneic stem cell transplantation. Transplant Proc. 42(9):3717-22, 2010