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Spine
Differential Diagnosis
Intervertebral Disc - Endplate
Modality-Specific Imaging Findings
Vertebral Endplate Signal Abnormality
Vertebral Endplate Signal Abnormality
Jeffrey S. Ross, MD
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DIFFERENTIAL DIAGNOSIS

    ESSENTIAL INFORMATION

    • Helpful Clues for Common Diagnoses

      • Alternative Differential Approaches

        Selected References

        1. Yang X et al: Association between Modic changes, disc degeneration, and neck pain in the cervical spine: a systematic review of literature. Spine J. 20(5):754-64, 2020
        2. Fields AJ et al: Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group. Eur Spine J. 28(10):2266-74, 2019
        3. Crockett MT et al: Modic Type 1 vertebral endplate changes: injury, inflammation, or infection? AJR Am J Roentgenol. 209(1):167-70, 2017
        4. Perilli E et al: Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling. Eur Spine J. 24(9):1926-34, 2015
        5. Peng BG: Pathophysiology, diagnosis, and treatment of discogenic low back pain. World J Orthop. 4(2):42-52, 2013
        6. Hutton MJ et al: Modic vertebral body changes: the natural history as assessed by consecutive magnetic resonance imaging. Spine (Phila Pa 1976). 36(26):2304-7, 2011
        7. Jensen TS et al: Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J. 17(11):1407-22, 2008
        8. Rahme R et al: The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine. AJNR Am J Neuroradiol. 29(5):838-42, 2008
        Related Anatomy
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        Related Differential Diagnoses
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        References
        Tables

        Tables

        DIFFERENTIAL DIAGNOSIS

          ESSENTIAL INFORMATION

          • Helpful Clues for Common Diagnoses

            • Alternative Differential Approaches

              Selected References

              1. Yang X et al: Association between Modic changes, disc degeneration, and neck pain in the cervical spine: a systematic review of literature. Spine J. 20(5):754-64, 2020
              2. Fields AJ et al: Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group. Eur Spine J. 28(10):2266-74, 2019
              3. Crockett MT et al: Modic Type 1 vertebral endplate changes: injury, inflammation, or infection? AJR Am J Roentgenol. 209(1):167-70, 2017
              4. Perilli E et al: Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling. Eur Spine J. 24(9):1926-34, 2015
              5. Peng BG: Pathophysiology, diagnosis, and treatment of discogenic low back pain. World J Orthop. 4(2):42-52, 2013
              6. Hutton MJ et al: Modic vertebral body changes: the natural history as assessed by consecutive magnetic resonance imaging. Spine (Phila Pa 1976). 36(26):2304-7, 2011
              7. Jensen TS et al: Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J. 17(11):1407-22, 2008
              8. Rahme R et al: The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine. AJNR Am J Neuroradiol. 29(5):838-42, 2008