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Vulvar and Vaginal Melanoma
Akram M. Shaaban, MBBCh; Evis Sala, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Subtype of cutaneous melanoma with similar prognostic and staging factors

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Trone JC et al: Melanomas of the female genital tract: state of the art. Bull Cancer. 101(1):102-106, 2014
                                            2. Janco JM et al: Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. Gynecol Oncol. 129(3):533-7, 2013
                                            3. Keller DS et al: Outcomes in patients with mucosal melanomas. J Surg Oncol. 108(8):516-20, 2013
                                            4. Mert I et al: Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. Int J Gynecol Cancer. 23(6):1118-25, 2013
                                            5. Hosseinzadeh K et al: Imaging of the female perineum in adults. Radiographics. 32(4):E129-68, 2012
                                            6. Tcheung WJ et al: Clinicopathologic study of 85 cases of melanoma of the female genitalia. J Am Acad Dermatol. 67(4):598-605, 2012
                                            7. Parikh JH et al: MR imaging features of vaginal malignancies. Radiographics. 28(1):49-63; quiz 322, 2008
                                            8. Sugiyama VE et al: Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol. 110(2 Pt 1):296-301, 2007
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Subtype of cutaneous melanoma with similar prognostic and staging factors

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Trone JC et al: Melanomas of the female genital tract: state of the art. Bull Cancer. 101(1):102-106, 2014
                                                                                      2. Janco JM et al: Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. Gynecol Oncol. 129(3):533-7, 2013
                                                                                      3. Keller DS et al: Outcomes in patients with mucosal melanomas. J Surg Oncol. 108(8):516-20, 2013
                                                                                      4. Mert I et al: Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. Int J Gynecol Cancer. 23(6):1118-25, 2013
                                                                                      5. Hosseinzadeh K et al: Imaging of the female perineum in adults. Radiographics. 32(4):E129-68, 2012
                                                                                      6. Tcheung WJ et al: Clinicopathologic study of 85 cases of melanoma of the female genitalia. J Am Acad Dermatol. 67(4):598-605, 2012
                                                                                      7. Parikh JH et al: MR imaging features of vaginal malignancies. Radiographics. 28(1):49-63; quiz 322, 2008
                                                                                      8. Sugiyama VE et al: Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol. 110(2 Pt 1):296-301, 2007