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Wallerian Degeneration
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Orthograde degeneration, secondary degeneration
              • Definitions

                • Disintegration of axon and myelin sheath after axonal connection to neuronal cell body is disrupted

              IMAGING

              • General Features

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          CLINICAL ISSUES

                          • Presentation

                            DIAGNOSTIC CHECKLIST

                            • Image Interpretation Pearls

                              Selected References

                              1. Koskinen E et al: Assessing the state of chronic spinal cord injury using diffusion tensor imaging. J Neurotrauma. 30(18):1587-95, 2013
                              2. Lindberg PG et al: Wallerian degeneration in lateral cervical spinal cord detected with diffusion tensor imaging in four chronic stroke patients. J Neuroimaging. 21(1):44-8, 2011
                              3. Guleria S et al: Retrograde Wallerian degeneration of cranial corticospinal tracts in cervical spinal cord injury patients using diffusion tensor imaging. J Neurosci Res. 86(10):2271-80, 2008
                              4. Matsusue E et al: Wallerian degeneration of the corticospinal tracts: postmortem MR-pathologic correlations. Acta Radiol. 48(6):690-4, 2007
                              5. Hagg T et al: Degenerative and spontaneous regenerative processes after spinal cord injury. J Neurotrauma. 23(3-4):264-80, 2006
                              6. Valencia MP et al: MRI findings in posttraumatic spinal cord Wallerian degeneration. Clin Imaging. 30(6):431-3, 2006
                              7. Beppu T et al: Utility of three-dimensional anisotropy contrast magnetic resonance axonography for determining condition of the pyramidal tract in glioblastoma patients with hemiparesis. J Neurooncol. 73(2):137-44, 2005
                              8. Buss A et al: Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord. Brain. 128(Pt 2):356-64, 2005
                              9. Kerschensteiner M et al: In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med. 11(5):572-7, 2005
                              10. Kakulas BA: Neuropathology: the foundation for new treatments in spinal cord injury. Spinal Cord. 42(10):549-63, 2004
                              11. Beattie MS et al: Cell death in models of spinal cord injury. Prog Brain Res. 137:37-47, 2002
                              12. Becerra JL et al: MR-pathologic comparisons of wallerian degeneration in spinal cord injury. AJNR Am J Neuroradiol. 16(1):125-33, 1995
                              13. Mascalchi M et al: MRI of wallerian degeneration in the cervical spinal cord. J Comput Assist Tomogr. 17(5):824-5, 1993
                              14. Kuhn MJ et al: Wallerian degeneration after cerebral infarction: evaluation with sequential MR imaging. Radiology. 172(1):179-82, 1989
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Clinical Issues

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Synonyms

                                            • Orthograde degeneration, secondary degeneration
                                          • Definitions

                                            • Disintegration of axon and myelin sheath after axonal connection to neuronal cell body is disrupted

                                          IMAGING

                                          • General Features

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Staging, Grading, & Classification

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        DIAGNOSTIC CHECKLIST

                                                        • Image Interpretation Pearls

                                                          Selected References

                                                          1. Koskinen E et al: Assessing the state of chronic spinal cord injury using diffusion tensor imaging. J Neurotrauma. 30(18):1587-95, 2013
                                                          2. Lindberg PG et al: Wallerian degeneration in lateral cervical spinal cord detected with diffusion tensor imaging in four chronic stroke patients. J Neuroimaging. 21(1):44-8, 2011
                                                          3. Guleria S et al: Retrograde Wallerian degeneration of cranial corticospinal tracts in cervical spinal cord injury patients using diffusion tensor imaging. J Neurosci Res. 86(10):2271-80, 2008
                                                          4. Matsusue E et al: Wallerian degeneration of the corticospinal tracts: postmortem MR-pathologic correlations. Acta Radiol. 48(6):690-4, 2007
                                                          5. Hagg T et al: Degenerative and spontaneous regenerative processes after spinal cord injury. J Neurotrauma. 23(3-4):264-80, 2006
                                                          6. Valencia MP et al: MRI findings in posttraumatic spinal cord Wallerian degeneration. Clin Imaging. 30(6):431-3, 2006
                                                          7. Beppu T et al: Utility of three-dimensional anisotropy contrast magnetic resonance axonography for determining condition of the pyramidal tract in glioblastoma patients with hemiparesis. J Neurooncol. 73(2):137-44, 2005
                                                          8. Buss A et al: Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord. Brain. 128(Pt 2):356-64, 2005
                                                          9. Kerschensteiner M et al: In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med. 11(5):572-7, 2005
                                                          10. Kakulas BA: Neuropathology: the foundation for new treatments in spinal cord injury. Spinal Cord. 42(10):549-63, 2004
                                                          11. Beattie MS et al: Cell death in models of spinal cord injury. Prog Brain Res. 137:37-47, 2002
                                                          12. Becerra JL et al: MR-pathologic comparisons of wallerian degeneration in spinal cord injury. AJNR Am J Neuroradiol. 16(1):125-33, 1995
                                                          13. Mascalchi M et al: MRI of wallerian degeneration in the cervical spinal cord. J Comput Assist Tomogr. 17(5):824-5, 1993
                                                          14. Kuhn MJ et al: Wallerian degeneration after cerebral infarction: evaluation with sequential MR imaging. Radiology. 172(1):179-82, 1989