Progressive secondary anterograde degeneration of axons and their myelin sheaths caused by interruption of axonal integrity or damage to neuron
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Zuo M et al: Wallerian degeneration in experimental focal cortical ischemia. Brain Res Bull. 149:194-202, 2019
Shen Y et al: Bilateral wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction: a case series. J Neurol Sci. 388:182-5, 2018
Zhang ZY et al: Clinical and radiological features of wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction. Chin Med J (Engl). 131(6):665-71, 2018
Chen YJ et al: Wallerian degeneration beyond the corticospinal tracts: conventional and advanced MRI findings. J Neuroimaging. 27(3):272-80, 2017
Jimenez-Gomez A et al: Teaching neuroimages: wallerian degeneration in evolving pediatric stroke. Neurology. 89(13):e166-7, 2017
Gandhi K et al: Progressive wallerian degeneration of the corpus callosal splenium in a patient with alexia without agraphia: advanced MR findings. Neuroradiol J. 27(6):653-6, 2014
Kleinman JT: Early wallerian degeneration on magnetic resonance imaging: underappreciated but highly relevant. Dev Med Child Neurol. 55(2):104-5, 2013
Saksena S et al: The corpus callosum wallerian degeneration in the unilateral brain tumors: evaluation with diffusion tensor imaging (DTI). J Clin Diagn Res. 7(2):320-5, 2013
Venkatasubramanian C et al: Natural history and prognostic value of corticospinal tract wallerian degeneration in intracerebral hemorrhage. J Am Heart Assoc. 2(4):e000090, 2013
Domi T et al: Corticospinal tract pre-wallerian degeneration: a novel outcome predictor for pediatric stroke on acute MRI. Stroke. 40(3):780-7, 2009
Liang Z et al: Progression of pathological changes in the middle cerebellar peduncle by diffusion tensor imaging correlates with lesser motor gains after pontine infarction. Neurorehabil Neural Repair. 23(7):692-8, 2009
Oh MY et al: Ipsilateral wallerian degeneration of the distal optic radiations after infarction at their root. J Neuroophthalmol. 29(2):146-8, 2009
Yu C et al: A longitudinal diffusion tensor imaging study on wallerian degeneration of corticospinal tract after motor pathway stroke. Neuroimage. 47(2):451-8, 2009
De Simone T et al: Wallerian degeneration of the pontocerebellar fibers. AJNR Am J Neuroradiol. 26(5):1062-5, 2005
Hunt D et al: ATF3 upregulation in glia during wallerian degeneration: differential expression in peripheral nerves and CNS white matter. BMC Neurosci. 5:9, 2004
Uchino A et al: Transient detection of early wallerian degeneration on diffusion-weighted MRI after an acute cerebrovascular accident. Neuroradiology. 46(3):183-8, 2004
Casanova B et al: Evidence of wallerian degeneration in normal appearing white matter in the early stages of relapsing-remitting multiple sclerosis: a HMRS study. J Neurol. 250(1):22-8, 2003
Mazumdar A et al: Diffusion-weighted imaging of acute corticospinal tract injury preceding wallerian degeneration in the maturing human brain. Am J Neuroradiol 24:1057-66, 2003
Pierpaoli C et al: Water diffusion changes in wallerian degeneration and their dependence on white matter architecture. Neuroimage. 13(6 Pt 1):1174-85, 2001
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
TERMINOLOGY
Abbreviations
Wallerian degeneration (WaD)
Definitions
Progressive secondary anterograde degeneration of axons and their myelin sheaths caused by interruption of axonal integrity or damage to neuron
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Zuo M et al: Wallerian degeneration in experimental focal cortical ischemia. Brain Res Bull. 149:194-202, 2019
Shen Y et al: Bilateral wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction: a case series. J Neurol Sci. 388:182-5, 2018
Zhang ZY et al: Clinical and radiological features of wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction. Chin Med J (Engl). 131(6):665-71, 2018
Chen YJ et al: Wallerian degeneration beyond the corticospinal tracts: conventional and advanced MRI findings. J Neuroimaging. 27(3):272-80, 2017
Jimenez-Gomez A et al: Teaching neuroimages: wallerian degeneration in evolving pediatric stroke. Neurology. 89(13):e166-7, 2017
Gandhi K et al: Progressive wallerian degeneration of the corpus callosal splenium in a patient with alexia without agraphia: advanced MR findings. Neuroradiol J. 27(6):653-6, 2014
Kleinman JT: Early wallerian degeneration on magnetic resonance imaging: underappreciated but highly relevant. Dev Med Child Neurol. 55(2):104-5, 2013
Saksena S et al: The corpus callosum wallerian degeneration in the unilateral brain tumors: evaluation with diffusion tensor imaging (DTI). J Clin Diagn Res. 7(2):320-5, 2013
Venkatasubramanian C et al: Natural history and prognostic value of corticospinal tract wallerian degeneration in intracerebral hemorrhage. J Am Heart Assoc. 2(4):e000090, 2013
Domi T et al: Corticospinal tract pre-wallerian degeneration: a novel outcome predictor for pediatric stroke on acute MRI. Stroke. 40(3):780-7, 2009
Liang Z et al: Progression of pathological changes in the middle cerebellar peduncle by diffusion tensor imaging correlates with lesser motor gains after pontine infarction. Neurorehabil Neural Repair. 23(7):692-8, 2009
Oh MY et al: Ipsilateral wallerian degeneration of the distal optic radiations after infarction at their root. J Neuroophthalmol. 29(2):146-8, 2009
Yu C et al: A longitudinal diffusion tensor imaging study on wallerian degeneration of corticospinal tract after motor pathway stroke. Neuroimage. 47(2):451-8, 2009
De Simone T et al: Wallerian degeneration of the pontocerebellar fibers. AJNR Am J Neuroradiol. 26(5):1062-5, 2005
Hunt D et al: ATF3 upregulation in glia during wallerian degeneration: differential expression in peripheral nerves and CNS white matter. BMC Neurosci. 5:9, 2004
Uchino A et al: Transient detection of early wallerian degeneration on diffusion-weighted MRI after an acute cerebrovascular accident. Neuroradiology. 46(3):183-8, 2004
Casanova B et al: Evidence of wallerian degeneration in normal appearing white matter in the early stages of relapsing-remitting multiple sclerosis: a HMRS study. J Neurol. 250(1):22-8, 2003
Mazumdar A et al: Diffusion-weighted imaging of acute corticospinal tract injury preceding wallerian degeneration in the maturing human brain. Am J Neuroradiol 24:1057-66, 2003
Pierpaoli C et al: Water diffusion changes in wallerian degeneration and their dependence on white matter architecture. Neuroimage. 13(6 Pt 1):1174-85, 2001
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