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Weight Fluctuations
Lauren Q. Chang Sen, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Alteration of breast size attributable to systemic weight changes

          IMAGING

          • General Features

            • Mammographic Findings

              DIFFERENTIAL DIAGNOSIS

                CLINICAL ISSUES

                • Demographics

                  DIAGNOSTIC CHECKLIST

                  • Consider

                    Selected References

                    1. Lope V et al: Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study. Sci Rep. 9(1):3904, 2019
                    2. Athilat S et al: Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City. Ann Epidemiol. ePub, 2018
                    3. Masala G et al: Can dietary and physical activity modifications reduce breast density in postmenopausal women? The DAMA study, a randomized intervention trial in Italy. Cancer Epidemiol Biomarkers Prev. ePub, 2018
                    4. Premenopausal Breast Cancer Collaborative Group et al: Association of body mass index and age with subsequent breast cancer risk in premenopausal women. JAMA Oncol. e181771, 2018
                    5. Byrne C et al: Mammographic Density Change With Estrogen and Progestin Therapy and Breast Cancer Risk. J Natl Cancer Inst. 109(9), 2017
                    6. Neuhouser ML et al: Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials. JAMA Oncol. 1(5):611-21, 2015
                    7. Kim J et al: Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer. Breast Cancer Res. 14(4):R102, 2012
                    8. Pollán M et al: Adult weight gain, fat distribution and mammographic density in Spanish pre- and post-menopausal women (DDM-Spain). Breast Cancer Res Treat. 134(2):823-38, 2012
                    9. Cuzick J et al: Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study. J Natl Cancer Inst. 103(9):744-52, 2011
                    10. Robbins J et al: Accuracy of diagnostic mammography and breast ultrasound during pregnancy and lactation. AJR Am J Roentgenol. 196(3):716-22, 2011
                    11. Sung J et al: Association of body size measurements and mammographic density in Korean women: the Healthy Twin study. Cancer Epidemiol Biomarkers Prev. 19(6):1523-31, 2010
                    12. Boyd NF et al: Mammographic density: a heritable risk factor for breast cancer. Methods Mol Biol. 472:343-60, 2009
                    13. Irwin ML et al: Physical activity, body mass index, and mammographic density in postmenopausal breast cancer survivors. J Clin Oncol. 25(9):1061-6, 2007
                    14. Chiarelli AM et al: Influence of patterns of hormone replacement therapy use and mammographic density on breast cancer detection. Cancer Epidemiol Biomarkers Prev. 15(10):1856-62, 2006
                    15. Boyd NF et al: Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol. 6(10):798-808, 2005
                    16. Patella A et al: Breast density changes associated with hormone replacement therapy in postmenopausal women. Effects on the specificity and sensitivity of mammographic screening. Eur J Gynaecol Oncol. 26(5):485-90, 2005
                    17. Swinford AE et al: Mammographic appearance of the breasts during pregnancy and lactation: false assumptions. Acad Radiol. 5(7):467-72, 1998
                    Related Anatomy
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                    Related Differential Diagnoses
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                    References
                    Tables

                    Tables

                    KEY FACTS

                    • Terminology

                      • Imaging

                        • Top Differential Diagnoses

                          • Clinical Issues

                            TERMINOLOGY

                            • Definitions

                              • Alteration of breast size attributable to systemic weight changes

                            IMAGING

                            • General Features

                              • Mammographic Findings

                                DIFFERENTIAL DIAGNOSIS

                                  CLINICAL ISSUES

                                  • Demographics

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Lope V et al: Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study. Sci Rep. 9(1):3904, 2019
                                      2. Athilat S et al: Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City. Ann Epidemiol. ePub, 2018
                                      3. Masala G et al: Can dietary and physical activity modifications reduce breast density in postmenopausal women? The DAMA study, a randomized intervention trial in Italy. Cancer Epidemiol Biomarkers Prev. ePub, 2018
                                      4. Premenopausal Breast Cancer Collaborative Group et al: Association of body mass index and age with subsequent breast cancer risk in premenopausal women. JAMA Oncol. e181771, 2018
                                      5. Byrne C et al: Mammographic Density Change With Estrogen and Progestin Therapy and Breast Cancer Risk. J Natl Cancer Inst. 109(9), 2017
                                      6. Neuhouser ML et al: Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials. JAMA Oncol. 1(5):611-21, 2015
                                      7. Kim J et al: Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer. Breast Cancer Res. 14(4):R102, 2012
                                      8. Pollán M et al: Adult weight gain, fat distribution and mammographic density in Spanish pre- and post-menopausal women (DDM-Spain). Breast Cancer Res Treat. 134(2):823-38, 2012
                                      9. Cuzick J et al: Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study. J Natl Cancer Inst. 103(9):744-52, 2011
                                      10. Robbins J et al: Accuracy of diagnostic mammography and breast ultrasound during pregnancy and lactation. AJR Am J Roentgenol. 196(3):716-22, 2011
                                      11. Sung J et al: Association of body size measurements and mammographic density in Korean women: the Healthy Twin study. Cancer Epidemiol Biomarkers Prev. 19(6):1523-31, 2010
                                      12. Boyd NF et al: Mammographic density: a heritable risk factor for breast cancer. Methods Mol Biol. 472:343-60, 2009
                                      13. Irwin ML et al: Physical activity, body mass index, and mammographic density in postmenopausal breast cancer survivors. J Clin Oncol. 25(9):1061-6, 2007
                                      14. Chiarelli AM et al: Influence of patterns of hormone replacement therapy use and mammographic density on breast cancer detection. Cancer Epidemiol Biomarkers Prev. 15(10):1856-62, 2006
                                      15. Boyd NF et al: Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol. 6(10):798-808, 2005
                                      16. Patella A et al: Breast density changes associated with hormone replacement therapy in postmenopausal women. Effects on the specificity and sensitivity of mammographic screening. Eur J Gynaecol Oncol. 26(5):485-90, 2005
                                      17. Swinford AE et al: Mammographic appearance of the breasts during pregnancy and lactation: false assumptions. Acad Radiol. 5(7):467-72, 1998