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Gastrointestinal
Diagnosis
Small Intestine
Inflammation
Whipple Disease
Whipple Disease
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Intestinal lipodystrophy

            • Definitions

              • Rare systemic disease caused by Tropheryma whipplei infection leading to multiple systemic manifestations, including chronic diarrhea and malabsorption

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Aguiar Ferreira A et al: Whipple's disease: imaging contribution for a challenging case. BMJ Case Rep. 13(2), 2020
                                          2. Antunes C et al: Whipple Disease 2020
                                          3. Nay J et al: Gastrointestinal manifestations of systemic disease: a multimodality review. Abdom Imaging. 40(6):1926-43, 2014
                                          4. Schwartzman S et al: Whipple's disease. Rheum Dis Clin North Am. 39(2):313-21, 2013
                                          5. Afshar P et al: Whipple's disease: a rare disease revisited. Curr Gastroenterol Rep. 12(4):263-9, 2010
                                          6. Freeman HJ: Tropheryma whipplei infection. World J Gastroenterol. 15(17):2078-80, 2009
                                          7. Iqbal T et al: Whipple's disease with constrictive pericarditis: a rare disease with a rare presentation. Can J Cardiol. 25(3):e89-91, 2009
                                          8. Martinetti M et al: The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple's disease. Gastroenterology. 136(7):2289-94, 2009
                                          9. Sanavro SM et al: Whipple's disease: easily diagnosed, if considered. Neth J Med. 67(3):108, 2009
                                          10. Herlinger H et al: Whipple disease malabsorption states. In Herlinger H et al eds. Clinical Imaging of the Small Intestine. 2nd ed. Springer-Verlag; 1999: 357-9
                                          11. Horton KM et al: Uncommon inflammatory diseases of the small bowel: CT findings. AJR Am J Roentgenol. 170(2):385-8, 1998
                                          12. Rubesin SE et al: Small bowel malabsorption: clinical and radiologic perspectives. How we see it. Radiology. 184(2):297-305, 1992
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Intestinal lipodystrophy

                                                    • Definitions

                                                      • Rare systemic disease caused by Tropheryma whipplei infection leading to multiple systemic manifestations, including chronic diarrhea and malabsorption

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Aguiar Ferreira A et al: Whipple's disease: imaging contribution for a challenging case. BMJ Case Rep. 13(2), 2020
                                                                                  2. Antunes C et al: Whipple Disease 2020
                                                                                  3. Nay J et al: Gastrointestinal manifestations of systemic disease: a multimodality review. Abdom Imaging. 40(6):1926-43, 2014
                                                                                  4. Schwartzman S et al: Whipple's disease. Rheum Dis Clin North Am. 39(2):313-21, 2013
                                                                                  5. Afshar P et al: Whipple's disease: a rare disease revisited. Curr Gastroenterol Rep. 12(4):263-9, 2010
                                                                                  6. Freeman HJ: Tropheryma whipplei infection. World J Gastroenterol. 15(17):2078-80, 2009
                                                                                  7. Iqbal T et al: Whipple's disease with constrictive pericarditis: a rare disease with a rare presentation. Can J Cardiol. 25(3):e89-91, 2009
                                                                                  8. Martinetti M et al: The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple's disease. Gastroenterology. 136(7):2289-94, 2009
                                                                                  9. Sanavro SM et al: Whipple's disease: easily diagnosed, if considered. Neth J Med. 67(3):108, 2009
                                                                                  10. Herlinger H et al: Whipple disease malabsorption states. In Herlinger H et al eds. Clinical Imaging of the Small Intestine. 2nd ed. Springer-Verlag; 1999: 357-9
                                                                                  11. Horton KM et al: Uncommon inflammatory diseases of the small bowel: CT findings. AJR Am J Roentgenol. 170(2):385-8, 1998
                                                                                  12. Rubesin SE et al: Small bowel malabsorption: clinical and radiologic perspectives. How we see it. Radiology. 184(2):297-305, 1992