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KEY FACTS
Terminology
Key Concepts
Clinical Implications
TERMINOLOGY
Abbreviations
World Health Organization (WHO)
Definitions
WHO criteria published in 1979 and 1981
Attempted to standardize criteria recording and reporting of response, recurrence, and disease-free interval
Adopted as standard method for evaluating tumor response at that time
Introduced concept of assessing response to therapy by change in sum of products of diameters (SPD)
SPD: Longest overall tumor diameter and longest diameter perpendicular to longest overall diameter
WHO criteria have largely been replaced by more recent guidelines (such as response evaluation criteria in solid tumors [RECIST])
May be encountered in some clinical protocols
Rationale and Key Concepts
Identify measurable disease
No maximum number of lesions specified
Calculate and evaluate change in SPD
IMAGING ANATOMY
Baseline Measurement Guidelines
CLINICAL IMPLICATIONS
Reassessment
Evaluation of Overall Response
Confirmation of Response
Limitations of WHO Criteria
Selected References
Tirkes T et al: Response criteria in oncologic imaging: review of traditional and new criteria. Radiographics. 33(5):1323-41, 2013
Kang H et al: Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts. Korean J Radiol. 13(4):371-90, 2012
Jaffe CC: Measures of response: RECIST, WHO, and new alternatives. J Clin Oncol. 24(20):3245-51, 2006
Choi JH et al: Comparison of WHO and RECIST criteria for response in metastatic colorectal carcinoma. Cancer Res Treat. 37(5):290-3, 2005
Therasse P et al: RECIST vs. WHO: prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma. Eur J Cancer. 41(10):1426-30, 2005
Park JO et al: Measuring response in solid tumors: comparison of RECIST and WHO response criteria. Jpn J Clin Oncol. 33(10):533-7, 2003
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References
Tables
Tables
KEY FACTS
Terminology
Key Concepts
Clinical Implications
TERMINOLOGY
Abbreviations
World Health Organization (WHO)
Definitions
WHO criteria published in 1979 and 1981
Attempted to standardize criteria recording and reporting of response, recurrence, and disease-free interval
Adopted as standard method for evaluating tumor response at that time
Introduced concept of assessing response to therapy by change in sum of products of diameters (SPD)
SPD: Longest overall tumor diameter and longest diameter perpendicular to longest overall diameter
WHO criteria have largely been replaced by more recent guidelines (such as response evaluation criteria in solid tumors [RECIST])
May be encountered in some clinical protocols
Rationale and Key Concepts
Identify measurable disease
No maximum number of lesions specified
Calculate and evaluate change in SPD
IMAGING ANATOMY
Baseline Measurement Guidelines
CLINICAL IMPLICATIONS
Reassessment
Evaluation of Overall Response
Confirmation of Response
Limitations of WHO Criteria
Selected References
Tirkes T et al: Response criteria in oncologic imaging: review of traditional and new criteria. Radiographics. 33(5):1323-41, 2013
Kang H et al: Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts. Korean J Radiol. 13(4):371-90, 2012
Jaffe CC: Measures of response: RECIST, WHO, and new alternatives. J Clin Oncol. 24(20):3245-51, 2006
Choi JH et al: Comparison of WHO and RECIST criteria for response in metastatic colorectal carcinoma. Cancer Res Treat. 37(5):290-3, 2005
Therasse P et al: RECIST vs. WHO: prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma. Eur J Cancer. 41(10):1426-30, 2005
Park JO et al: Measuring response in solid tumors: comparison of RECIST and WHO response criteria. Jpn J Clin Oncol. 33(10):533-7, 2003
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