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KEY FACTS
Terminology
Key Concepts
Clinical Implications
TERMINOLOGY
Abbreviations
- World Health Organization (WHO)
Definitions
- WHO criteria published in 1979 and 1981
- Attempted to standardize criteria recording and reporting of response, recurrence, and disease-free interval
- Adopted as standard method for evaluating tumor response at that time
- Introduced concept of assessing response to therapy by change in sum of products of diameters (SPD)
- SPD: Longest overall tumor diameter and longest diameter perpendicular to longest overall diameter
- WHO criteria have largely been replaced by more recent guidelines (such as response evaluation criteria in solid tumors [RECIST])
- May be encountered in some clinical protocols
- WHO criteria published in 1979 and 1981
Rationale and Key Concepts
- Identify measurable disease
- No maximum number of lesions specified
- Calculate and evaluate change in SPD
IMAGING ANATOMY
Baseline Measurement Guidelines
CLINICAL IMPLICATIONS
Reassessment
Evaluation of Overall Response
Confirmation of Response
Limitations of WHO Criteria
Selected References
- Tirkes T et al: Response criteria in oncologic imaging: review of traditional and new criteria. Radiographics. 33(5):1323-41, 2013
- Kang H et al: Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts. Korean J Radiol. 13(4):371-90, 2012
- Jaffe CC: Measures of response: RECIST, WHO, and new alternatives. J Clin Oncol. 24(20):3245-51, 2006
- Choi JH et al: Comparison of WHO and RECIST criteria for response in metastatic colorectal carcinoma. Cancer Res Treat. 37(5):290-3, 2005
- Therasse P et al: RECIST vs. WHO: prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma. Eur J Cancer. 41(10):1426-30, 2005
- Park JO et al: Measuring response in solid tumors: comparison of RECIST and WHO response criteria. Jpn J Clin Oncol. 33(10):533-7, 2003
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References
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Tables
KEY FACTS
Terminology
Key Concepts
Clinical Implications
TERMINOLOGY
Abbreviations
- World Health Organization (WHO)
Definitions
- WHO criteria published in 1979 and 1981
- Attempted to standardize criteria recording and reporting of response, recurrence, and disease-free interval
- Adopted as standard method for evaluating tumor response at that time
- Introduced concept of assessing response to therapy by change in sum of products of diameters (SPD)
- SPD: Longest overall tumor diameter and longest diameter perpendicular to longest overall diameter
- WHO criteria have largely been replaced by more recent guidelines (such as response evaluation criteria in solid tumors [RECIST])
- May be encountered in some clinical protocols
- WHO criteria published in 1979 and 1981
Rationale and Key Concepts
- Identify measurable disease
- No maximum number of lesions specified
- Calculate and evaluate change in SPD
IMAGING ANATOMY
Baseline Measurement Guidelines
CLINICAL IMPLICATIONS
Reassessment
Evaluation of Overall Response
Confirmation of Response
Limitations of WHO Criteria
Selected References
- Tirkes T et al: Response criteria in oncologic imaging: review of traditional and new criteria. Radiographics. 33(5):1323-41, 2013
- Kang H et al: Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts. Korean J Radiol. 13(4):371-90, 2012
- Jaffe CC: Measures of response: RECIST, WHO, and new alternatives. J Clin Oncol. 24(20):3245-51, 2006
- Choi JH et al: Comparison of WHO and RECIST criteria for response in metastatic colorectal carcinoma. Cancer Res Treat. 37(5):290-3, 2005
- Therasse P et al: RECIST vs. WHO: prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma. Eur J Cancer. 41(10):1426-30, 2005
- Park JO et al: Measuring response in solid tumors: comparison of RECIST and WHO response criteria. Jpn J Clin Oncol. 33(10):533-7, 2003
