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Wilms Tumor
Hank Baskin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Nephroblastoma, embryoma of kidney (archaic)
            • Definitions

              • Malignant tumor of primitive metanephric blastema
              • Most common abdominal neoplasm ages 1-8 years

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Echocardiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Chung EM et al: Renal tumors of childhood: radiologic-pathologic correlation part 1. The 1st decade: from the Radiologic Pathology Archives. Radiographics. 36(2):499-522, 2016
                                                2. Kieran K et al: Current surgical standards of care in Wilms tumor. Urol Oncol. 34(1):13-23, 2016
                                                3. Qin Z et al: Use of 18F-FDG-PET-CT for assessment of response to neoadjuvant chemotherapy in children with Wilms tumor. J Pediatr Hematol Oncol. 37(5):396-401, 2015
                                                4. Servaes S et al: Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group. Pediatr Radiol. 45(2):166-72, 2015
                                                5. Khanna G et al: Detection of preoperative wilms tumor rupture with CT: a report from the Children's Oncology Group. Radiology. 266(2):610-7, 2013
                                                6. Provenzi M et al: Is there a role for FDG-PET for the assessment of treatment efficacy in Wilms' tumor? A case report and literature review. Pediatr Hematol Oncol. 30(7):633-9, 2013
                                                7. Khanna G et al: Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 58(4):551-5, 2012
                                                8. Begent J et al: Pilot study of F(18)-Fluorodeoxyglucose Positron Emission Tomography/computerised tomography in Wilms' tumour: correlation with conventional imaging, pathology and immunohistochemistry. Eur J Cancer. 47(3):389-96, 2011
                                                9. Piwkowski P et al: Potential role of PET-CT in chemotherapy efficacy assessment and recurrence diagnosis in a patient with a Wilms' tumour. Nucl Med Rev Cent East Eur. 14(1):33-5, 2011
                                                10. Smets AM et al: Malignant tumours of the kidney: imaging strategy. Pediatr Radiol. 40(6):1010-8, 2010
                                                11. Jia HM et al: Presacral extrarenal Wilms tumor in a child. Urology. 74(2):308-10, 2009
                                                12. Davidoff AM et al: The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer. 112(9):2060-70, 2008
                                                13. Miniati D et al: Imaging accuracy and incidence of Wilms' and non-Wilms' renal tumors in children. J Pediatr Surg. 43(7):1301-7, 2008
                                                14. Merks JH et al: High incidence of malformation syndromes in a series of 1,073 children with cancer. Am J Med Genet A. 134(2):132-43, 2005
                                                15. Lonergan GJ et al: Nephrogenic rests, nephroblastomatosis, and associated lesions of the kidney. Radiographics. 18(4):947-68, 1998
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          TERMINOLOGY

                                                          • Synonyms

                                                            • Nephroblastoma, embryoma of kidney (archaic)
                                                          • Definitions

                                                            • Malignant tumor of primitive metanephric blastema
                                                            • Most common abdominal neoplasm ages 1-8 years

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Ultrasonographic Findings

                                                                    • Echocardiographic Findings

                                                                      • Nuclear Medicine Findings

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Chung EM et al: Renal tumors of childhood: radiologic-pathologic correlation part 1. The 1st decade: from the Radiologic Pathology Archives. Radiographics. 36(2):499-522, 2016
                                                                                              2. Kieran K et al: Current surgical standards of care in Wilms tumor. Urol Oncol. 34(1):13-23, 2016
                                                                                              3. Qin Z et al: Use of 18F-FDG-PET-CT for assessment of response to neoadjuvant chemotherapy in children with Wilms tumor. J Pediatr Hematol Oncol. 37(5):396-401, 2015
                                                                                              4. Servaes S et al: Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group. Pediatr Radiol. 45(2):166-72, 2015
                                                                                              5. Khanna G et al: Detection of preoperative wilms tumor rupture with CT: a report from the Children's Oncology Group. Radiology. 266(2):610-7, 2013
                                                                                              6. Provenzi M et al: Is there a role for FDG-PET for the assessment of treatment efficacy in Wilms' tumor? A case report and literature review. Pediatr Hematol Oncol. 30(7):633-9, 2013
                                                                                              7. Khanna G et al: Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 58(4):551-5, 2012
                                                                                              8. Begent J et al: Pilot study of F(18)-Fluorodeoxyglucose Positron Emission Tomography/computerised tomography in Wilms' tumour: correlation with conventional imaging, pathology and immunohistochemistry. Eur J Cancer. 47(3):389-96, 2011
                                                                                              9. Piwkowski P et al: Potential role of PET-CT in chemotherapy efficacy assessment and recurrence diagnosis in a patient with a Wilms' tumour. Nucl Med Rev Cent East Eur. 14(1):33-5, 2011
                                                                                              10. Smets AM et al: Malignant tumours of the kidney: imaging strategy. Pediatr Radiol. 40(6):1010-8, 2010
                                                                                              11. Jia HM et al: Presacral extrarenal Wilms tumor in a child. Urology. 74(2):308-10, 2009
                                                                                              12. Davidoff AM et al: The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer. 112(9):2060-70, 2008
                                                                                              13. Miniati D et al: Imaging accuracy and incidence of Wilms' and non-Wilms' renal tumors in children. J Pediatr Surg. 43(7):1301-7, 2008
                                                                                              14. Merks JH et al: High incidence of malformation syndromes in a series of 1,073 children with cancer. Am J Med Genet A. 134(2):132-43, 2005
                                                                                              15. Lonergan GJ et al: Nephrogenic rests, nephroblastomatosis, and associated lesions of the kidney. Radiographics. 18(4):947-68, 1998