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Wilms Tumor
Ethan A. Smith, MDHank Baskin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Nephroblastoma
            • Definitions

              • Malignant tumor of primitive metanephric blastema
              • Most common abdominal neoplasm ages 1-8 years

            IMAGING

            • General Features

              • Radiographic Findings

                • Ultrasonographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Sandberg JK et al: Imaging characteristics of nephrogenic rests versus small wilms tumors: a report from the Children's Oncology Group Study AREN03B2. AJR Am J Roentgenol. 214(5):987-94, 2020
                                              2. Servaes SE et al: Imaging of Wilms tumor: an update. Pediatr Radiol. 49(11):1441-52, 2019
                                              3. Stanescu AL et al: Pediatric renal neoplasms: MR imaging-based practical diagnostic approach. Magn Reson Imaging Clin N Am. 27(2):279-90, 2019
                                              4. Chung EM et al: Renal tumors of childhood: radiologic-pathologic correlation part 1. The 1st decade: from the Radiologic Pathology Archives. Radiographics. 36(2):499-522, 2016
                                              5. Kieran K et al: Current surgical standards of care in Wilms tumor. Urol Oncol. 34(1):13-23, 2016
                                              6. Servaes S et al: Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group. Pediatr Radiol. 45(2):166-72, 2015
                                              7. Gawande RS et al: Role of diffusion-weighted imaging in differentiating benign and malignant pediatric abdominal tumors. Pediatr Radiol. 43(7):836-45, 2013
                                              8. Khanna G et al: Detection of preoperative wilms tumor rupture with CT: a report from the Children's Oncology Group. Radiology. 266(2):610-7, 2013
                                              9. Provenzi M et al: Is there a role for FDG-PET for the assessment of treatment efficacy in Wilms' tumor? A case report and literature review. Pediatr Hematol Oncol. 30(7):633-9, 2013
                                              10. Khanna G et al: Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 58(4):551-5, 2012
                                              11. Smets AM et al: Malignant tumours of the kidney: imaging strategy. Pediatr Radiol. 40(6):1010-8, 2010
                                              12. Jia HM et al: Presacral extrarenal Wilms tumor in a child. Urology. 74(2):308-10, 2009
                                              13. Davidoff AM et al: The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer. 112(9):2060-70, 2008
                                              14. Lonergan GJ et al: Nephrogenic rests, nephroblastomatosis, and associated lesions of the kidney. Radiographics. 18(4):947-68, 1998
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Nephroblastoma
                                                        • Definitions

                                                          • Malignant tumor of primitive metanephric blastema
                                                          • Most common abdominal neoplasm ages 1-8 years

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • Ultrasonographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Sandberg JK et al: Imaging characteristics of nephrogenic rests versus small wilms tumors: a report from the Children's Oncology Group Study AREN03B2. AJR Am J Roentgenol. 214(5):987-94, 2020
                                                                                          2. Servaes SE et al: Imaging of Wilms tumor: an update. Pediatr Radiol. 49(11):1441-52, 2019
                                                                                          3. Stanescu AL et al: Pediatric renal neoplasms: MR imaging-based practical diagnostic approach. Magn Reson Imaging Clin N Am. 27(2):279-90, 2019
                                                                                          4. Chung EM et al: Renal tumors of childhood: radiologic-pathologic correlation part 1. The 1st decade: from the Radiologic Pathology Archives. Radiographics. 36(2):499-522, 2016
                                                                                          5. Kieran K et al: Current surgical standards of care in Wilms tumor. Urol Oncol. 34(1):13-23, 2016
                                                                                          6. Servaes S et al: Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group. Pediatr Radiol. 45(2):166-72, 2015
                                                                                          7. Gawande RS et al: Role of diffusion-weighted imaging in differentiating benign and malignant pediatric abdominal tumors. Pediatr Radiol. 43(7):836-45, 2013
                                                                                          8. Khanna G et al: Detection of preoperative wilms tumor rupture with CT: a report from the Children's Oncology Group. Radiology. 266(2):610-7, 2013
                                                                                          9. Provenzi M et al: Is there a role for FDG-PET for the assessment of treatment efficacy in Wilms' tumor? A case report and literature review. Pediatr Hematol Oncol. 30(7):633-9, 2013
                                                                                          10. Khanna G et al: Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 58(4):551-5, 2012
                                                                                          11. Smets AM et al: Malignant tumours of the kidney: imaging strategy. Pediatr Radiol. 40(6):1010-8, 2010
                                                                                          12. Jia HM et al: Presacral extrarenal Wilms tumor in a child. Urology. 74(2):308-10, 2009
                                                                                          13. Davidoff AM et al: The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer. 112(9):2060-70, 2008
                                                                                          14. Lonergan GJ et al: Nephrogenic rests, nephroblastomatosis, and associated lesions of the kidney. Radiographics. 18(4):947-68, 1998