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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Wilson disease (WD)
Synonyms
- Hepatolenticular degeneration
Definitions
- Autosomal recessive disorder in which copper (Cu) accumulates pathologically
- Primarily within liver and subsequently in neurologic system and other tissues
- Autosomal recessive disorder in which copper (Cu) accumulates pathologically
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Guglielmo FF et al: Liver MR elastography technique and image interpretation: pearls and pitfalls. Radiographics. 39(7):1983-2002, 2019
- Członkowska A et al: Wilson disease. Nat Rev Dis Primers. 4(1):21, 2018
- Salari M et al: Magnetic resonance imaging findings in diagnosis and prognosis of Wilson disease. J Res Med Sci. 23:23, 2018
- Stättermayer AF et al: Hepatic steatosis in Wilson disease--role of copper and PNPLA3 mutations. J Hepatol. 63(1):156-63, 2015
- Schilsky ML: Liver transplantation for Wilson's disease. Ann N Y Acad Sci. 1315:45-9, 2014
- Weiss KH et al: Clinical considerations for an effective medical therapy in Wilson's disease. Ann N Y Acad Sci. 1315:81-5, 2014
- Eapen CE: Copper and liver disease. Gut. 61(1):63, 2012
- Bennett J et al: Clinical molecular diagnosis of Wilson disease. Semin Liver Dis. 31(3):233-8, 2011
- Harada M et al: Excess copper chelating therapy for Wilson disease induces anemia and liver dysfunction. Intern Med. 50(14):1461-4, 2011
- Johncilla M et al: Pathology of the liver in copper overload. Semin Liver Dis. 31(3):239-44, 2011
- Cheon JE et al: Clinical application of liver MR imaging in Wilson's disease. Korean J Radiol. 11(6):665-72, 2010
- Rosencrantz R et al: Wilson disease: pathogenesis and clinical considerations in diagnosis and treatment. Semin Liver Dis. 31(3):245-59, 2011
- Cheng F et al: Outcomes of living-related liver transplantation for Wilson's disease: a single-center experience in China. Transplantation. 87(5):751-7, 2009
- Mak CM et al: Diagnosis of Wilson's disease: a comprehensive review. Crit Rev Clin Lab Sci. 45(3):263-90, 2008
- Tarnacka B et al: MR spectroscopy in monitoring the treatment of Wilson's disease patients. Mov Disord. 23(11):1560-6, 2008
- Akhan O et al: Unusual imaging findings in Wilson's disease. Eur Radiol. 12 Suppl 3:S66-9, 2002
- Ko S et al: Unusual liver MR findings of Wilson's disease in an asymptomatic 2-year-old girl. Abdom Imaging. 23(1):56-9, 1998
- Garg RK et al: Wilson's disease: unusual clinical and radiological features. J Assoc Physicians India. 42(3):253-4, 1994
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Wilson disease (WD)
Synonyms
- Hepatolenticular degeneration
Definitions
- Autosomal recessive disorder in which copper (Cu) accumulates pathologically
- Primarily within liver and subsequently in neurologic system and other tissues
- Autosomal recessive disorder in which copper (Cu) accumulates pathologically
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Guglielmo FF et al: Liver MR elastography technique and image interpretation: pearls and pitfalls. Radiographics. 39(7):1983-2002, 2019
- Członkowska A et al: Wilson disease. Nat Rev Dis Primers. 4(1):21, 2018
- Salari M et al: Magnetic resonance imaging findings in diagnosis and prognosis of Wilson disease. J Res Med Sci. 23:23, 2018
- Stättermayer AF et al: Hepatic steatosis in Wilson disease--role of copper and PNPLA3 mutations. J Hepatol. 63(1):156-63, 2015
- Schilsky ML: Liver transplantation for Wilson's disease. Ann N Y Acad Sci. 1315:45-9, 2014
- Weiss KH et al: Clinical considerations for an effective medical therapy in Wilson's disease. Ann N Y Acad Sci. 1315:81-5, 2014
- Eapen CE: Copper and liver disease. Gut. 61(1):63, 2012
- Bennett J et al: Clinical molecular diagnosis of Wilson disease. Semin Liver Dis. 31(3):233-8, 2011
- Harada M et al: Excess copper chelating therapy for Wilson disease induces anemia and liver dysfunction. Intern Med. 50(14):1461-4, 2011
- Johncilla M et al: Pathology of the liver in copper overload. Semin Liver Dis. 31(3):239-44, 2011
- Cheon JE et al: Clinical application of liver MR imaging in Wilson's disease. Korean J Radiol. 11(6):665-72, 2010
- Rosencrantz R et al: Wilson disease: pathogenesis and clinical considerations in diagnosis and treatment. Semin Liver Dis. 31(3):245-59, 2011
- Cheng F et al: Outcomes of living-related liver transplantation for Wilson's disease: a single-center experience in China. Transplantation. 87(5):751-7, 2009
- Mak CM et al: Diagnosis of Wilson's disease: a comprehensive review. Crit Rev Clin Lab Sci. 45(3):263-90, 2008
- Tarnacka B et al: MR spectroscopy in monitoring the treatment of Wilson's disease patients. Mov Disord. 23(11):1560-6, 2008
- Akhan O et al: Unusual imaging findings in Wilson's disease. Eur Radiol. 12 Suppl 3:S66-9, 2002
- Ko S et al: Unusual liver MR findings of Wilson's disease in an asymptomatic 2-year-old girl. Abdom Imaging. 23(1):56-9, 1998
- Garg RK et al: Wilson's disease: unusual clinical and radiological features. J Assoc Physicians India. 42(3):253-4, 1994
