Rare inflammatory process causing focal or diffuse destruction of gallbladder (GB) wall, with accumulation of lipid-laden macrophages, fibrous tissue, and acute and chronic inflammatory cells
Uncommon variant of chronic cholecystitis, associated with destructive granulomatous reaction to bile
Benign condition that may be confused with GB carcinoma
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bennett G et al: Cholelithiasis, cholecystitis, choledocholithiasis, and hyperplastic cholecystoses. In Gore RM et al: Textbook of Gastrointestinal Radiology. 4th ed. Saunders Elsevier, 2015
Lopes Vendrami C et al: Gallbladder carcinoma and its differential diagnosis at MRI: what radiologists should know. Radiographics. 41(1):78-95, 2021
Ratanaprasatporn L et al: Multimodality imaging, including dual-energy CT, in the evaluation of gallbladder disease. Radiographics. 38(1):75-89, 2018
Lamps LW et al: Gallbladder and Extrahepatic Bile Ducts. Lamps LW et al: Rosai and Ackerman's Surgical Pathology. 11th ed. Elsevier. 854, 2017
Yuan HX et al: Xanthogranulomatous cholecystitis: contrast-enhanced ultrasound features and differential diagnosis from wall-thickening gallbladder carcinoma. Discov Med. 21(114):89-98, 2016
Revzin MV et al: The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. 40:385–399, 2015
Kang TW et al: Differentiating xanthogranulomatous cholecystitis from wall-thickening type of gallbladder cancer: added value of diffusion-weighted MRI. Clin Radiol. 68(10):992-1001, 2013
Levy AD et al: Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: Radiologic-pathologic correlation. RadioGraphics. 22: 387-413, 2002
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Xanthogranulomatous cholecystitis (XGC)
Definitions
Rare inflammatory process causing focal or diffuse destruction of gallbladder (GB) wall, with accumulation of lipid-laden macrophages, fibrous tissue, and acute and chronic inflammatory cells
Uncommon variant of chronic cholecystitis, associated with destructive granulomatous reaction to bile
Benign condition that may be confused with GB carcinoma
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bennett G et al: Cholelithiasis, cholecystitis, choledocholithiasis, and hyperplastic cholecystoses. In Gore RM et al: Textbook of Gastrointestinal Radiology. 4th ed. Saunders Elsevier, 2015
Lopes Vendrami C et al: Gallbladder carcinoma and its differential diagnosis at MRI: what radiologists should know. Radiographics. 41(1):78-95, 2021
Ratanaprasatporn L et al: Multimodality imaging, including dual-energy CT, in the evaluation of gallbladder disease. Radiographics. 38(1):75-89, 2018
Lamps LW et al: Gallbladder and Extrahepatic Bile Ducts. Lamps LW et al: Rosai and Ackerman's Surgical Pathology. 11th ed. Elsevier. 854, 2017
Yuan HX et al: Xanthogranulomatous cholecystitis: contrast-enhanced ultrasound features and differential diagnosis from wall-thickening gallbladder carcinoma. Discov Med. 21(114):89-98, 2016
Revzin MV et al: The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. 40:385–399, 2015
Kang TW et al: Differentiating xanthogranulomatous cholecystitis from wall-thickening type of gallbladder cancer: added value of diffusion-weighted MRI. Clin Radiol. 68(10):992-1001, 2013
Levy AD et al: Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: Radiologic-pathologic correlation. RadioGraphics. 22: 387-413, 2002
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.