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Xanthogranulomatous Cholecystitis
Siva P. Raman, MD; Mitchell Tublin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Xanthogranulomatous cholecystitis (XGC)
          • Synonyms

            • Fibroxanthogranulomatous cholecystitis; xanthogranulomatous cholangitis
          • Definitions

            • Rare inflammatory disorder of gallbladder (GB) characterized by accumulation of lipid-laden macrophages and fibrous tissue

          IMAGING

          • General Features

            • Imaging Recommendations

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Lee NK et al: Diffusion-weighted magnetic resonance imaging for non-neoplastic conditions in the hepatobiliary and pancreatic regions: pearls and potential pitfalls in imaging interpretation. Abdom Imaging. ePub, 2014
                                          2. Revzin MV et al: The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. Epub ahead of print, 2014
                                          3. Kang TW et al: Differentiating xanthogranulomatous cholecystitis from wall-thickening type of gallbladder cancer: added value of diffusion-weighted MRI. Clin Radiol. 68(10):992-1001, 2013
                                          4. Zhao F et al: CT and MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases. Eur J Radiol. 82(9):1391-7, 2013
                                          5. Arora A et al: Xanthogranulomatous cholecystitis: characteristic CT findings. Indian J Gastroenterol. 31(2):85, 2012
                                          6. Shetty GS et al: Xanthogranulomatous cholecystitis: sonographic and CT features and differentiation from gallbladder carcinoma: a pictorial essay. Jpn J Radiol. 30(6):480-5, 2012
                                          7. Goshima S et al: Xanthogranulomatous cholecystitis: diagnostic performance of CT to differentiate from gallbladder cancer. Eur J Radiol. 74(3):e79-83, 2010
                                          8. Kim JH et al: Is xanthogranulomatous cholecystitis the most difficult for laparoscopic cholecystectomy? Hepatogastroenterology. 56(91-92):597-601, 2009
                                          9. Uchiyama K et al: Xanthogranulomatous cholecystitis: the use of preoperative CT findings to differentiate it from gallbladder carcinoma. J Hepatobiliary Pancreat Surg. 16(3):333-8, 2009
                                          10. Klarenbeek BR et al: Percutaneous gallbladder drainage for xanthogranulomatous cholecystitis. Surg Laparosc Endosc Percutan Tech. 18(5):506-7, 2008
                                          11. Kwon AH et al: Simultaneous presence of xanthogranulomatous cholecystitis and gallbladder cancer. J Gastroenterol. 42(8):703-4, 2007
                                          12. Yang T et al: Surgical treatment of xanthogranulomatous cholecystitis: experience in 33 cases. Hepatobiliary Pancreat Dis Int. 6(5):504-8, 2007
                                          13. Shuto R et al: CT and MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol. 14(3):440-6, 2004
                                          14. Iannicelli E et al: A case of xanthogranulomatous cholecystitis: integrated US-CT imaging. Radiol Med. 104(1-2):106-10, 2002
                                          15. Parra JA et al: Xanthogranulomatous cholecystitis: clinical, sonographic, and CT findings in 26 patients. AJR Am J Roentgenol. 174(4):979-83, 2000
                                          16. Kim PN et al: Xanthogranulomatous cholecystitis: radiologic findings with histologic correlation that focuses on intramural nodules. AJR Am J Roentgenol. 172(4):949-53, 1999
                                          17. Won YH et al: Knuckle pad-like keratoderma: a new cutaneous side reaction induced by tegafur. Int J Dermatol. 37(4):315-7, 1998
                                          18. Chun KA et al: Xanthogranulomatous cholecystitis: CT features with emphasis on differentiation from gallbladder carcinoma. Radiology. 203(1):93-7, 1997
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Xanthogranulomatous cholecystitis (XGC)
                                                  • Synonyms

                                                    • Fibroxanthogranulomatous cholecystitis; xanthogranulomatous cholangitis
                                                  • Definitions

                                                    • Rare inflammatory disorder of gallbladder (GB) characterized by accumulation of lipid-laden macrophages and fibrous tissue

                                                  IMAGING

                                                  • General Features

                                                    • Imaging Recommendations

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Lee NK et al: Diffusion-weighted magnetic resonance imaging for non-neoplastic conditions in the hepatobiliary and pancreatic regions: pearls and potential pitfalls in imaging interpretation. Abdom Imaging. ePub, 2014
                                                                                  2. Revzin MV et al: The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. Epub ahead of print, 2014
                                                                                  3. Kang TW et al: Differentiating xanthogranulomatous cholecystitis from wall-thickening type of gallbladder cancer: added value of diffusion-weighted MRI. Clin Radiol. 68(10):992-1001, 2013
                                                                                  4. Zhao F et al: CT and MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases. Eur J Radiol. 82(9):1391-7, 2013
                                                                                  5. Arora A et al: Xanthogranulomatous cholecystitis: characteristic CT findings. Indian J Gastroenterol. 31(2):85, 2012
                                                                                  6. Shetty GS et al: Xanthogranulomatous cholecystitis: sonographic and CT features and differentiation from gallbladder carcinoma: a pictorial essay. Jpn J Radiol. 30(6):480-5, 2012
                                                                                  7. Goshima S et al: Xanthogranulomatous cholecystitis: diagnostic performance of CT to differentiate from gallbladder cancer. Eur J Radiol. 74(3):e79-83, 2010
                                                                                  8. Kim JH et al: Is xanthogranulomatous cholecystitis the most difficult for laparoscopic cholecystectomy? Hepatogastroenterology. 56(91-92):597-601, 2009
                                                                                  9. Uchiyama K et al: Xanthogranulomatous cholecystitis: the use of preoperative CT findings to differentiate it from gallbladder carcinoma. J Hepatobiliary Pancreat Surg. 16(3):333-8, 2009
                                                                                  10. Klarenbeek BR et al: Percutaneous gallbladder drainage for xanthogranulomatous cholecystitis. Surg Laparosc Endosc Percutan Tech. 18(5):506-7, 2008
                                                                                  11. Kwon AH et al: Simultaneous presence of xanthogranulomatous cholecystitis and gallbladder cancer. J Gastroenterol. 42(8):703-4, 2007
                                                                                  12. Yang T et al: Surgical treatment of xanthogranulomatous cholecystitis: experience in 33 cases. Hepatobiliary Pancreat Dis Int. 6(5):504-8, 2007
                                                                                  13. Shuto R et al: CT and MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol. 14(3):440-6, 2004
                                                                                  14. Iannicelli E et al: A case of xanthogranulomatous cholecystitis: integrated US-CT imaging. Radiol Med. 104(1-2):106-10, 2002
                                                                                  15. Parra JA et al: Xanthogranulomatous cholecystitis: clinical, sonographic, and CT findings in 26 patients. AJR Am J Roentgenol. 174(4):979-83, 2000
                                                                                  16. Kim PN et al: Xanthogranulomatous cholecystitis: radiologic findings with histologic correlation that focuses on intramural nodules. AJR Am J Roentgenol. 172(4):949-53, 1999
                                                                                  17. Won YH et al: Knuckle pad-like keratoderma: a new cutaneous side reaction induced by tegafur. Int J Dermatol. 37(4):315-7, 1998
                                                                                  18. Chun KA et al: Xanthogranulomatous cholecystitis: CT features with emphasis on differentiation from gallbladder carcinoma. Radiology. 203(1):93-7, 1997