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Xanthogranulomatous Cholecystitis
Maria A. Manning, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Xanthogranulomatous cholecystitis (XGC)
            • Synonyms

              • Fibroxanthogranulomatous cholecystitis
            • Definitions

              • Rare inflammatory process causing focal or diffuse destruction of gallbladder (GB) wall, with accumulation of lipid-laden macrophages, fibrous tissue, and acute and chronic inflammatory cells
              • Uncommon variant of chronic cholecystitis, associated with destructive granulomatous reaction to bile
              • Benign condition that may be confused with gallbladder carcinoma

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Bennett G et al: Cholelithiasis, cholecystitis, choledocholithiasis, and hyperplastic cholecystoses. In Gore RM et al: Textbook of Gastrointestinal Radiology. 4th ed. Philadelphia: Saunders Elsevier. Ch. 77, 2015
                                          2. Revzin MV et al: The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. Epub ahead of print, 2014
                                          3. Smith EA et al: Cross-sectional imaging of acute and chronic gallbladder inflammatory disease. AJR Am J Roentgenol. 192(1):188-96, 2009
                                          4. Catalano OA et al: MR imaging of the gallbladder: a pictorial essay. Radiographics. 28(1):135-55; quiz 324, 2008
                                          5. Levy AD et al: Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: Radiologic-pathologic correlation. RadioGraphics. 22: 387-413, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Xanthogranulomatous cholecystitis (XGC)
                                                    • Synonyms

                                                      • Fibroxanthogranulomatous cholecystitis
                                                    • Definitions

                                                      • Rare inflammatory process causing focal or diffuse destruction of gallbladder (GB) wall, with accumulation of lipid-laden macrophages, fibrous tissue, and acute and chronic inflammatory cells
                                                      • Uncommon variant of chronic cholecystitis, associated with destructive granulomatous reaction to bile
                                                      • Benign condition that may be confused with gallbladder carcinoma

                                                    IMAGING

                                                    • General Features

                                                      • Ultrasonographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Bennett G et al: Cholelithiasis, cholecystitis, choledocholithiasis, and hyperplastic cholecystoses. In Gore RM et al: Textbook of Gastrointestinal Radiology. 4th ed. Philadelphia: Saunders Elsevier. Ch. 77, 2015
                                                                                  2. Revzin MV et al: The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. Epub ahead of print, 2014
                                                                                  3. Smith EA et al: Cross-sectional imaging of acute and chronic gallbladder inflammatory disease. AJR Am J Roentgenol. 192(1):188-96, 2009
                                                                                  4. Catalano OA et al: MR imaging of the gallbladder: a pictorial essay. Radiographics. 28(1):135-55; quiz 324, 2008
                                                                                  5. Levy AD et al: Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: Radiologic-pathologic correlation. RadioGraphics. 22: 387-413, 2002